A5103215395- Genetic and phenotypic traits in livestock
- Meat and Animal Product Quality
- Effects of Environmental Stressors on Livestock
- Animal Behavior and Welfare Studies
- Immune Cell Function and Interaction
- Animal Nutrition and Physiology
- T-cell and B-cell Immunology
- Reproductive Physiology in Livestock
- Organic Electronics and Photovoltaics
- Metal and Thin Film Mechanics
- Conducting polymers and applications
- Genetic Mapping and Diversity in Plants and Animals
- Immunotherapy and Immune Responses
- Semiconductor materials and devices
- Cutaneous lymphoproliferative disorders research
- Plasma Diagnostics and Applications
- T-cell and Retrovirus Studies
- Hormonal Regulation and Hypertension
- Vitamin K Research Studies
- Systemic Lupus Erythematosus Research
- Viral-associated cancers and disorders
- Vitamin C and Antioxidants Research
- Cytomegalovirus and herpesvirus research
- Wood Treatment and Properties
- Rheumatoid Arthritis Research and Therapies
Tsurugi Hospital
2024
University of Hyogo
2016-2018
National Institute for Materials Science
2013
University of Miyazaki
1985-2012
Japan Atomic Energy Agency
2012
Brigham and Women's Hospital
2005
Harvard University
2003-2005
Beth Israel Deaconess Medical Center
2005
Tokyo University of Agriculture
2001-2004
Food & Nutrition
2003
Inducible costimulatory molecule (ICOS) plays a pivotal role in T cell activation and Th1/Th2 differentiation. ICOS blockade has disparate effects on immune responses depending the timing of blockade. Its transplantation immunity, however, remains incompletely defined. We used vascularized mouse cardiac allograft model to explore signaling at different time points after transplantation, targeting initiation (early blockade) or effector phase (delayed blockade). In major...
Inducible costimulatory molecule (ICOS) plays a pivotal role in T cell activation and Th1/Th2 differentiation. ICOS blockade has disparate effects on immune responses depending the timing of blockade. Its transplantation immunity, however, remains incompletely defined. We used vascularized mouse cardiac allograft model to explore signaling at different time points after transplantation, targeting initiation (early blockade) or effector phase (delayed blockade). In major...
<h3>Objective:</h3> To elucidate clinicopathologic manifestations of cutaneous lymphoproliferative disorders associated with Epstein-Barr virus (EBV) infection. <h3>Design:</h3> Retrospective survey case series. <h3>Setting:</h3> University hospital medical center. <h3>Patients:</h3> Sixty-five patients lymphomas and related disorders. <h3>Main Outcome Measures:</h3> Detection EBV genes EBV-encoded small nuclear RNAs. <h3>Results:</h3> Evidence latent infection was demonstrated in 15...
The inability to reproducibly induce robust and durable transplant tolerance using CD28-B7 pathway blockade is in part related the persistence of alloreactive effector/memory CD8(+) T cells that are less dependent on this for their cellular activation. We studied role novel cell costimulatory pathway, CD27-CD70, alloimmunity presence absence signaling. CD70 prolonged survival fully mismatched vascularized cardiac allografts wild-type murine recipients, CD28-deficient mice induced long-term...
Some regions of the genomes human B-lymphotrophic virus (HBLV), also designated as herpesvirus 6, and Marek's disease were found to hybridize each other under moderate stringent conditions, scoring from 10 30% base-pair mismatch. Nucleotide sequence analysis showed that a 6-base-pair repetitive sequence, GGGTTA (DR2), present in IRS-IRL junction region genome, was reiterated HBLV genome. The function(s) such is unknown, but this first report homology between nonhuman herpesvirus.
Abstract The mechanisms underlying physiological regulation of alloimmune responses remain poorly defined. We investigated the roles cytokines, CTLA-4, CD25+ T cells, and apoptosis in regulating vivo. Two murine cardiac transplant models were used, B10.D2 (minor mismatch) C57BL/6 (major mismatch), into BALB/c recipients. Recipients wild type, STAT4−/− (Th1 deficient), or STAT6−/− (Th2 deficient) mice. Minor mismatched allografts accepted spontaneously ∼70% type By contrast, there was...
A polymeric bipolar TFT with a single channel layer has been successfully realized. In the present TFT, interpenetrating network layer, consisting of PAT12 and electron transport dye, was formed by spin-coating. The current-voltage characteristics are qualitatively similar to those heterostructure TFT. some advantages in fabrication compared
In our search for molecules involved in the process of osteoclast differentiation, we examined surface phenotypes preosteoclast-like cells and osteoclast-like multinucleated (MNCs) formed bone marrow cultures, using monoclonal antibodies recognizing different antigen expressed on hematopoietic cells. Among these cell antigens, lymphocyte function-associated antigen-1 (LFA-1) intercellular adhesion molecule-1 (ICAM-1) were highly mononuclear cultures forming The double detection two with...
A diet containing a high concentration of soy isoflavone was administered to laying hens and the contents isoflavones transferred plasma egg yolk were measured. method for quantitatively measuring in first established, before over an 18-day period. The concentrations reached their highest on 12th day feeding period, values being 3,167 nmol/l 65.29 microg/100 g, respectively. cholesterol slightly affected during early stages These findings clearly demonstrate that into from feed by...
Peripheral tolerance can be achieved in many but not all murine allograft models. The requirements for controlling more aggressive immune responsiveness and generating peripheral stringent models are unknown. Understanding these will provide insight toward ultimately achieving humans, which also resistant. We now demonstrate that the combination of donor-specific transfusion, anti-CD45RB, anti-CD154 uniformly achieves >90-d survival BALB/c skin allografts on C57BL/6 recipients. Recipients...
To realize a high current under focusing operation we investigated the structure of double-gated field emitter arrays (FEAs) and tried to anodize tip silicon emitters. It was found from these investigations that FEAs with thick extraction gate could maintain emission during operation. Furthermore, anodized Si achieved per about 300 nA
The difference between vitamin K metabolism in the liver and that bone of K-deficient rats was examined. After 17 d administration food, almost depleted, prothrombin time (PT) prolonged. Serum total osteocalcin level slightly decreased by deficiency, whereas serum undercarboxylated did not change. menaquinone (MK)-4 as well phylloquinone decreased, but approximately 40 % initial still existed femur after period. A single-dose (250 nmol/kg body weight) markedly increased femur. These results...
The objectives of this study were to detect effective genetic polymorphisms bovine growth hormone (bGH) gene associated with calf weight in Japanese Black cattle. Fifty-eight sires and 47 breeding cows used the exons by single-strand conformation polymorphism (SSCP). Four homozygous six heterozygous SSCP genotypes identified exon 5. Although each single nucleotide (SNP) had been reported, these caused three SNPs at positions 2141, 2277 2291. haplotypes C-C-A, G-C-A, C-C-C G-T-A newly...
Abstract Antiserum toward soybean meal was prepared by feeding a diet containing large amounts of antigens to calves. The antiserum used develop sensitive detection method for competitive inhibition enzyme‐linked immunosorbent assay. With this method, the effectiveness twin‐screw extrusion cooking in reducing antigenicity examined. Antigenicity reduced 0.1% original activity with screws kneading‐disc elements and die‐end temperatures exceeding 66°C. Electrophoretic analysis cooked indicated...
A new method of carbonization without heat treatment has been developed. Electrochemical reduction hexachlorobuta-1,3-diene in aprotic solvents affords an electroactive black polymer film. The film consists mainly carbon ( > 62%), and a small amount chlorine is distributed heterogeneously the Raman spectroscopy X-ray diffraction analysis have revealed that considerable part turbostratic graphitic structure. Chemical polymerization by Yamamoto with magnesium nickel complex forms fine...
We thank Iwatsuki and colleagues for their interest in our article.<sup>1</sup>The goal of study was to make the point that different types T-cell lymphoma may initially present with involvement subcutaneous tissue, which a subset cases are examples panniculitic lymphoma. This view is shared by others, such as Burg et al.<sup>2</sup>To illustrate we reported 2 cases. Patient 1 woman who presented multiple, nonulcerated, plaques associated clinical laboratory evidence suggestive...
Leaf discs of Perilla frutescens var. crispa f. viridi-crispa were cultured on a defined medium to investigate factors influencing bud and root formation, callus induction, somatic embryogenesis, floral formation. Addition naphthalene-acetic acid (NAA) the culture caused compact whereas 2,4-dichlorophenoxy acetic (2,4-D) promoted soft friable formation surface explants. Benzyladenine, when applied with auxin, suppressed Somatic embryogenesis occurred, explants first grown nutrient containing...
The difference between vitamin K metabolism in the liver and that bone of K-deficient rats was examined. After 17 d administration food, almost depleted, prothrombin time (PT) prolonged. Serum total osteocalcin level slightly decreased by deficiency, whereas serum undercarboxylated did not change. menaquinone (MK)-4 as well phylloquinone decreased, but approximately 40 % initial still existed femur after period. A single-dose (250 nmol/kg body weight) markedly increased femur. These results...