A5076246186- Cancer and Skin Lesions
- Inflammasome and immune disorders
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Nail Diseases and Treatments
- Cutaneous lymphoproliferative disorders research
- Cardiac tumors and thrombi
- Vascular Tumors and Angiosarcomas
- Cutaneous Melanoma Detection and Management
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Contact Dermatitis and Allergies
- Herpesvirus Infections and Treatments
- Nonmelanoma Skin Cancer Studies
- Viral Infections and Immunology Research
- Polyomavirus and related diseases
- Genetic and rare skin diseases.
- Food Allergy and Anaphylaxis Research
- Immune Response and Inflammation
- Mast cells and histamine
- Hedgehog Signaling Pathway Studies
- Autoimmune and Inflammatory Disorders
- melanin and skin pigmentation
- Dermatological and Skeletal Disorders
- Sarcoidosis and Beryllium Toxicity Research
Kyoto University
2010-2019
Kyoto University Hospital
2015
Tenri Hospital
2009-2011
Abstract Objective Blau syndrome and its sporadic counterpart, early‐onset sarcoidosis (EOS), share a phenotype featuring the symptom triad of skin rash, arthritis, uveitis. This systemic inflammatory granulomatosis is associated with mutations in NOD2 gene. The aim this study was to describe clinical manifestations syndrome/EOS Japanese patients determine whether genotype basal NF‐κB activity predict phenotype. Methods Twenty were recruited. Mutated categorized based on activity, which...
Abstract Chronic infantile neurologic, cutaneous, articular syndrome (CINCA syndrome) is a severe inflammatory disease that was recently found to be associated with mutations in CIAS1 . However, have been detected only half of CINCA patients, and it remains unclear which genes are responsible for the remaining patients. We describe here patient who exhibited somatic mosaicism. genetically analyzed gene various blood cells buccal mucosa patient. The production interleukin‐1β (IL‐1β) by...
Food-dependent exercise-induced anaphylaxis (FDEIA) is a distinct form of common food allergy characteristically induced by combination causative ingestion and physical exercise. Recent investigations have documented that aspirin consumption, in place exercise, also induces allergic symptoms. A 63-year-old man began low dose therapy on September 2005. Since January 2006, he had repeated episodes generalized urticaria lost consciousness while was exercising after eating wheat. He strongly...
In extramammary Paget disease (EMPD), cells are sometimes detected outside the clinical border (subclinical extension). However, spreading pattern of in subclinical extension remains unclear. addition, macroscopic appearances lesions accompanied by totally unknown.To characterize as well appearance EMPD with extension.Nineteen patients primary anogenital underwent mapping biopsies and excisional surgeries; biopsy samples were then taken at periphery well-demarcated lesions. Samples...
Herein we report a rare case of disseminated herpes zoster(HZ) infection involving two widely separated bilateral dermatomes in an immunocompetent host. HZ areas simultaneously is referred to as duplex bilateralis. It very rare, with incidence less than 0.1 percent all cases, and usually develops immunocompromised patients.
Abstract Some familial cases of pityriasis rubra pilaris ( PRP ) have the CARD 14 gene mutations that are also detected in psoriasis vulgaris. However, genotype–phenotype correlation these two entities is poorly understood. Here, we report a case with new mutation . Genomic analysis 40‐year‐old female patient sporadic type V identified heterozygous dominant c.412G>A (p.Glu138Lys) Two types causing Glu138 substitutions been reported and pustular psoriasis. All three types, including...
Abstract Conditions that influence the selective development or recruitment of connective tissue-type and mucosal-type mast cells (MCs) are not well understood. Here, we report cynomolgus monkey embryonic stem (ES) cocultured with murine aorta-gonad-mesonephros-derived stromal cell line AGM-S1 differentiated into cobblestone (CS)-like by day 10–15. When replated onto fresh addition factor, interleukin-6, Flt3 ligand, these CS-like displayed robust growth generated almost 100%...
Pulse corticosteroid therapy is effective for alopecia areata (AA) in the early stage. The risk and efficacy of this patients with several backgrounds, however, remains controversial. To explore predictive factors response therapy, data from 105 AA treated methylprednisolone (500 mg) i.v. 3 days consecutively our facility were retrospectively analyzed. Among good responders, longer time onset to was correlated required hair regrowth (P = 0.037, n 27). Multivariate models demonstrated that...
This paper reported a case of onychomadesis which appeared on the nails after heal cutaneous lesions hand-foot-mouth disease (HFMD). There were few reports describing HFMD; however, mechanism is still unclear. The present was prospectively observed, and found to develop only having HFMD. We considered that nail dysfunction due direct inflammation spreading from skin eruptions around one causes linked
This paper reports a case of adult HFMD with vesicles scattered on the whole body and severe oral lesions. In addition, long-lasting elevated level C-reactive protein (CRP) was feature this case. Our is unusual for joint pain high fever.
An epidermal cyst is a common benign subcutaneous tumor and rarely develops malignancy. We report case of an undifferentiated cutaneous squamous cell carcinoma (SCC) that arose from on the left side neck. The had rapidly increased in size presented cauliflower-like tumor. Histological study revealed was arising cyst.
Several randomized trials have shown that breast-conserving therapy (BCT) is as effective mastectomy and should be a standard treatment for early-stage breast cancer. Recently, there has been an increase in reports of angiosarcoma (AS) after BCT. Herein, we report case AS which developed BCT Stewart-Treves syndrome with focus on lymphedema. Chronic lymphedema the primary risk factor AS, was first described 1948 by Stewart Treves [Cancer 1948;1:64-81]. Radiation secondarily tends to induce...
Seborrheic dermatitis is an inflammatory eruption that tends to distribute on the sebaceous areas of body and rarely described as a paraneoplasia. Here we report case with responsive seborrheic dermatitis-like head which resulted in generalized erythroderma. Intensive examinations detected concurrent malignant lymphoma.