A5035759709- Glycosylation and Glycoproteins Research
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- Food Allergy and Anaphylaxis Research
- Cytomegalovirus and herpesvirus research
- Carbohydrate Chemistry and Synthesis
- Mast cells and histamine
- Galectins and Cancer Biology
- Viral-associated cancers and disorders
- Reconstructive Surgery and Microvascular Techniques
- T-cell and Retrovirus Studies
- Urinary Bladder and Prostate Research
- Craniofacial Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Cleft Lip and Palate Research
- Acute Myeloid Leukemia Research
- Allergic Rhinitis and Sensitization
- CNS Lymphoma Diagnosis and Treatment
- Urological Disorders and Treatments
Kyoto University
2003-2020
Kyoto University Hospital
2004-2017
Kurume University
2012
The University of Tokyo
1982-2008
Tokyo University of Agriculture and Technology
2008
National Jewish Health
2007
University of Colorado Denver
2007
University of Colorado Health
2007
Park Terrace Care Center
2007
Yuan's General Hospital
2007
B7‐H1 is a member of the B7 family that inhibits function T‐cells through its receptor programmed death‐1 (PD‐1). We examined expression in anaplastic large cell lymphoma (ALCL) and Hodgkin (HL) found it was constitutively expressed both clinical samples lines. In kinase–positive (ALK + ) ALCL cells, suppressed by blocking extracellular signal‐regulated kinase (ERK) signaling upregulated augmentation ERK activity phorbol 13‐myristate 12‐acetate stimulation, suggesting regulated pathway ALCL....
Mucosal-associated invariant T (MAIT) cells are innate-like involved in the homeostasis of mucosal immunity; however, their role inflammatory bowel disease (IBD) is unclear.Flow cytometry was used to enumerate peripheral blood MAIT 88 patients with ulcerative colitis (UC), 68 Crohn's (CD), and 57 healthy controls. Immunohistochemistry identified intestinal tissue samples from UC (n = 5) CD 10), control colon small intestine 9) samples. In addition, expression activated caspases by 14 15 CD,...
Abstract Expression of sialyl Lewisa is known to be increased in cancers the digestive organs. The determinant serves as a ligand for E-selectin and mediates hematogenous metastasis cancers. In contrast, disialyl Lewisa, which has an extra sialic acid attached at C6-position penultimate GlcNAc expressed preferentially on nonmalignant colonic epithelial cells, its expression decreases significantly malignant transformation. Introduction gene α2→6 sialyl-transferase responsible synthesis colon...
Studies suggest that cytomegalovirus (CMV) infection exacerbates ulcerative colitis (UC) refractory to immunosuppressive therapies. Early and accurate diagnosis of CMV is important for the treatment UC. We evaluated usefulness quantitative real-time polymerase chain reaction (PCR) detecting in inflamed colonic mucosa patients with UC therapies.From 2003 2006, 30 (mean age: 41 +/- 18 years; 14 men, 16 women) therapies were enrolled study. by antigenemia, histologic examination, PCR using...
Abstract Chronic infantile neurologic, cutaneous, articular syndrome (CINCA syndrome) is a severe inflammatory disease that was recently found to be associated with mutations in CIAS1 . However, have been detected only half of CINCA patients, and it remains unclear which genes are responsible for the remaining patients. We describe here patient who exhibited somatic mosaicism. genetically analyzed gene various blood cells buccal mucosa patient. The production interleukin‐1β (IL‐1β) by...
Immune cells are known to express specific recognition molecules for cell surface glycans. However, mechanisms involved in glycan-mediated cell-cell interactions mucosal immunity have largely been left unaccounted for. We found that several glycans preferentially expressed nonmalignant colonic epithelial serve as ligands sialic acid-binding Ig-like lectins (siglecs), the immunosuppressive carbohydrate-recognition receptors carried by immune cells. The siglec ligand normal included disialyl...
Although the effectiveness of rituximab has been reported in ABO blood group (ABO)-incompatible (ABO-I) organ transplantation, protocol is not yet established. We studied impact timing prophylaxis and humoral immune response patients undergoing ABO-I living donor liver transplantation (LDLT), focusing on clinicopathological findings B-cell subset. From July 2003 to December 2005, 30 adult were treated with hepatic artery infusion (HAI) without splenectomy for LDLT. A total 17 only HAI (no...
CD22/Siglec-2, an important inhibitory co-receptor on B-lymphocytes, is known to recognize α2-6-sialylated glycan as a specific ligand. Here we propose that the and 6-GlcNAc-sulfated determinant serves preferred ligand for CD22 because binding of human B-cell line was almost completely abrogated after incubating cells with NaClO3, inhibitor cellular sulfate metabolism, also significantly inhibited by newly generated monoclonal antibody 6-sulfo-N-acetyllactosamine (LacNAc) (KN343, murine...
Ferritin is an iron-storage protein composed of different ratios 24 light (L) and heavy (H) subunits. The serum level ferritin a clinical marker the body's iron level. Transferrin receptor (TFR)1 not only for transferrin but also H-ferritin, how it binds two ligands blood cell types that preferentially incorporate H-ferritin remain unknown. To address these questions, we investigated hematopoietic cell-specific uptake by flow cytometry. Alexa Fluor 488-labeled was incorporated erythroid...
We provide here evidence that supports the occurrence of a biologically dormant form selectin ligand carbohydrate, sialyl 6-sulfo Lewis X containing modified sialic acid, in human leukocytes. The modification acid involves first de-N-acetylation moiety through ubiquitous de-N-acetylation/re-N-acetylation cycle, followed by dehydrative cyclization de-N-acetyl to "cyclic acid." enzyme involved dehydration is calcium-dependent having neutral-alkaline pH optimum. De-N-acetyl retained binding...
Background and aim: Cytomegalovirus (CMV) exacerbates ulcerative colitis (UC) refractory to immunosuppressive therapies. The conditions under which CMV reactivation occurs in patients with UC, however, is unclear. In addition, the diagnostic treatment strategies for UC positive have not been established. Granulocyte monocyte adsorptive apheresis (GMAA) natural biological therapy granulocytes/macrophages producing inflammatory cytokines are removed. We investigated rate of colonic efficacy...