A5027272532- Skin and Cellular Biology Research
- Autoimmune Bullous Skin Diseases
- Genetic and rare skin diseases.
- Dermatological and Skeletal Disorders
- Cancer and Skin Lesions
- Cell Adhesion Molecules Research
- Hedgehog Signaling Pathway Studies
- Porphyrin Metabolism and Disorders
- Urticaria and Related Conditions
- Heme Oxygenase-1 and Carbon Monoxide
- Nail Diseases and Treatments
- Cutaneous lymphoproliferative disorders research
- Autoimmune and Inflammatory Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- RNA regulation and disease
- Trace Elements in Health
- Contact Dermatitis and Allergies
- Eosinophilic Disorders and Syndromes
- Cellular Mechanics and Interactions
- Tumors and Oncological Cases
- Hair Growth and Disorders
- Oral Health Pathology and Treatment
- interferon and immune responses
- Melanoma and MAPK Pathways
- Vascular Malformations and Hemangiomas
Hirosaki University
2015-2024
Hirosaki University Hospital
2022
Immune Regulation (United Kingdom)
2017
Yokohama City University
2015-2017
Yamagata University
2007
Thomas Jefferson University
2001-2007
Aomori Prefectural Central Hospital
2007
Jefferson Institute
2001-2007
Tokyo National Hospital
1997
Wakunaga (Japan)
1996
Zinc deficiency can be an inherited disorder, in which case it is known as acrodermatitis enteropathica (AE), or acquired disorder caused by low dietary intake of zinc. Even though zinc diminishes cellular and humoral immunity, patients develop immunostimulating skin inflammation. Here, we have demonstrated that despite diminished allergic contact dermatitis mice fed a zinc-deficient (ZD) diet, irritant (ICD) these was more severe prolonged than controls. Further, histological examination...
Abstract Perforating dermatoses are a heterogeneous skin disease group defined by transepidermal elimination of various materials. Four classical forms primary perforating dermatosis have been described, where the mechanism represents hallmark disease: acquired reactive collagenosis, elastosis perforans serpiginosa, Kyrle’s and folliculitis. Acquired collagenosis presents with collagen fibers. Elastosis serpiginosum elastic abnormal keratin. In folliculitis, it is content follicle. We...
Most models of hereditary hypotrichosis are due to alterations in growth factors and transcription factors, the examples causative mutations hair keratin genes limited. The Hirosaki hairless rat (HHR) is a mutant strain spontaneously derived from Sprague-Dawley rats (SDRs). In this study, locus responsible gene was examined by linkage analysis mapped on chromosome 7q36. Because many basic clustered 7q36, their expression examined. Reverse transcription-PCR genomic PCR indicated that Kb21...
Recently, patients with hypohidrotic/anhidrotic ectodermal dysplasia (H/AED) have been reported to a higher prevalence of symptoms suggestive atopic disorders than the general population. To better understand diathesis in H/AED, 6 cases clinically or genetically diagnosed H/AED were examined. The following criteria evaluated patient consent: sweating, blood test results, histopathology and filaggrin staining. Five displayed dermatitis-like manifestations, 3 these 5 experienced periorbital...
Alopecia associated with epidermal growth factor receptor (EGFR) inhibitor therapy is a rare cutaneous side effect the potential to progress scarring alopecia. Thus, dermatologists should make an early diagnosis. We present case of 57-year-old Japanese female alopecia gefitinib, which EGFR inhibitor, including trichoscopic findings. The patient treated gefitinib for non-small cell lung cancer experienced skin rash and hair loss scalp. scalp lesions appeared similar erosive pustular...
Abstract Impetigo herpetiformis (IH) is a rare variant of generalized pustular psoriasis (GPP), which develops during pregnancy. GPP associated with mutations IL36RN , but it still unclear whether the same true IH. A 20‐year‐old Japanese woman developed erythema and pustules on her trunk 27th week first Within 1 month, skin lesions spread over whole body, accompanied by fever. Skin biopsy revealed Kogoj’s spongiform in epidermis she was diagnosed Systemic administration prednisolone failed...
Phosphatidylethanolamine-binding protein (PEBP) has been demonstrated to bind Raf-1 and mitogen-activated kinase kinase, components of the extracellular signal-regulated (ERK) pathway, thereby inhibiting pathway resulting in suppression cell proliferation. In present study, we examined whether PEBP is involved differentiation induction human keratinocytes. expression was immunohistochemically normal skin cancers with different properties. not expressed basal layer epidermis but spinous...
Photodynamic therapy (PDT) using topical delta-aminolevulinic acid (ALA) has been used for nonmelanoma skin cancers, including malignant cutaneous T-cell lymphomas. Moreover, PDT tried benign inflammatory or infectious lesions.To evaluate the effects of ALA-PDT on lesions lymphadenosis benigna cutis (LABC).Two 16-year-old females with solitary and infiltrated nodules were treated 5 times ALA-PDT.Both patients responded well showed dramatic clinical histopathological improvement without...
Conflicts of interest: none declared. Cowden syndrome (CS; OMIM 158350) is a rare genetic disorder that characterized by multiple hamartomas (affecting various organs derived from all three germ layers) and an increased risk some cancers, in particular thyroid breast cancers.1 The lifetime risks for cancer are estimated to be 3–10% 25–50%, respectively.1 Characteristic mucocutaneous manifestations include facial trichilemmomas, oral mucosal papillomatoses acral keratoses. These clinical...