A5008904393- Schizophrenia research and treatment
- Treatment of Major Depression
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Bipolar Disorder and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Electroconvulsive Therapy Studies
- Hormonal Regulation and Hypertension
- Stress Responses and Cortisol
- Drug-Induced Hepatotoxicity and Protection
- Electrolyte and hormonal disorders
- Tryptophan and brain disorders
- Autism Spectrum Disorder Research
- Pharmaceutical studies and practices
- Cancer Treatment and Pharmacology
- Metabolism and Genetic Disorders
- Adrenal Hormones and Disorders
- Telomeres, Telomerase, and Senescence
- Attention Deficit Hyperactivity Disorder
- Traumatic Brain Injury and Neurovascular Disturbances
- Ginseng Biological Effects and Applications
Saku Central Hospital
2024
Jikei University School of Medicine
2024
Yamagata University
2001-2019
Yamagata University Hospital
2005
Hirosaki University
1988-1999
Hirosaki University Hospital
1989-1998
GTx (United States)
1998
May Institute
1996
Moscow Research and Clinical Center for Neuropsychiatry
1995
Nihon University
1994
The pathophysiology of neuroleptic malignant syndrome is mainly explained by a central hypodopaminergic state. familial occurrence suggests the involvement genetic mechanism in predisposition to syndrome. Therefore, authors examined association between TaqI A polymorphism dopamine D(2) receptor gene (DRD(2)), which alters DRD(2) density and function, development syndrome.The subjects were 15 psychiatric patients who had developed (12 with schizophrenia three major depression) 138 never...
There is a growing body of data suggesting that gene-environment interaction critical in the characterization personality traits; however, previous studies have not taken into consideration variability parental rearing as an environmental factor.In this study, we examined effects between brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and on traits 710 healthy Japanese subjects.Perceived was assessed by Parental Bonding Instrument (PBI), which consists care protection...
To clarify the involvement of cytochrome P4502D6 (CYP2D6) in metabolism trazodone, effects coadministration thioridazine, which is an inhibitor this isozyme, on plasma concentrations trazodone and its active metabolite m-chlorophenylpiperazine (m-CPP) were studied. The subjects 11 depressed patients receiving at bedtime for 1–18 weeks. dose was 150 mg 10 300 one. Thioridazine 40 mg/day coadministered 1 week, blood samplings performed before after coadministration. significantly (p < 0.001)...
Effects of various factors on steady state plasma concentrations trazodone and its active metabolitem-chlorophenylpiperazine (mCPP) were studied in 43 depressed patients (19 males, 24 females) receiving 150 mg at bedtime for 1-3 weeks. Sixteen cases smokers, 19 also benzodiazepines. The means (and ranges) mCPP, the mCPP/trazodone ratio 619 (251-1059) ng/ml, 59 (32-139) ng/ml 0.100 (0.044-0.219), respectively. Smokers had significantly (p< 0.05) lower higher ratios than non-smokers. Age, sex...
It has been shown that certain personality traits are related to mortality and disease morbidity, but the biological mechanism linking them remains unclear. Telomeres tandem repeat DNA sequences located at ends of chromosomes, shorter telomere length is a predictor late-life morbidity. Thus, it possible influence length. In present study, we examined relationship leukocyte with in healthy subjects.The subjects were 209 unrelated Japanese who recruited from medical students 4th-5th grade....
Effects of carbamazepine coadministration on plasma concentrations trazodone and its active metabolite, m-chlorophenylpiperazine (m-CPP) were studied in six depressed patients treated with trazodone. The daily dose was 150 mg three cases 300 cases. Carbamazepine, 400 mg/day, coadministered for 4 weeks, blood samples taken before addition at weekly intervals after the addition. Carbamazepine significantly (p < 0.01) decreased not only but also m-CPP each week. On average, weeks 24 40%...
Serum concentrations of valproic acid (VPA) and its mono‐unsaturated metabolites, 2‐propyl‐2‐pentenoic (2‐en), 2‐propyl‐3‐pentenoic (3‐en) 2‐propyl‐4‐pentenoic (4‐en), were measured in 36 epileptic patients. The subjects divided into three subgroups, i.e., receiving VPA alone (n = 20: group), with phenytoin 9: + DPH carbamazepine 7: CBZ group). In the group, correlations between serum concentration those metabolites significantly positive (r 0.693, P less than 0.01 for 2‐en; r 0.584, 3‐en;...
since transurethral resection two weeks before.Is this appreciable reduction in morbidity?Certainly he did not have to stay long hospital, but who is say that the current operative technique more agreeable than open prostatectomy-it done by same surgeons, registrars, and house officers with intact prostates, assert retrograde ejaculation elicits sensation as normal.And one of them consider asking me whether I wanted another child before thev rendered mv husband infertile?Nomy consent was...
Cultured Glycyrrhiza echinata L. (Leguminosae) cells produce a retrochalcone echinatin (4,4[prime]-dihydroxy-2-methoxychalcone) and its biosynthetic intermediate licodione [1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-1,3-propanedione, dibenzoylmethane (keto form) or enol tautomer ([beta]-hydroxychalcone)], when treated with elicitor-active substances, e.g. yeast extract. A microsomal fraction (160,000g pellet) prepared from extract-induced suspension cultures of G. catalyzed the formation...
Three cases developed withdrawal symptoms of trazodone despite gradual discontinuation therapeutic doses the drug. This report suggests that effects and its metabolite m-chlorophenylpiperazine on serotonergic system, which may result in noradrenergic rebound after discontinuation, short half-lives these compounds are involved development symptoms. From a clinical point view, we suggest should be tapered off at very slow rate.
Abstract The steady‐state serum kinetics of zotepine, an antipsychotic drug, were studied in 59 psychiatric in‐patients receiving 50–500 mg/day (mean 215 mg/day) the drug. There was a 26‐fold inter‐individual variation concentration/dose ratios (C/D ratios: ng/ml/mg/kg), which ranged from 2.4 to 62.2 13.2). smokers ( n = 37) had significantly lower C/D ±SD: 9.7 ± 7.0 vs 19.0 15.5, p < 0.01), while patients co‐administered benzodiazepines 14) higher (19.06 12.5 11.2 10.9, 0.01) than...
Aims Globular glial tauopathy (GGT) is a new category within the 4‐repeat tauopathies that characterised neuropathologically by tau‐positive globular inclusions (GGIs), namely, oligodendrocytic and astrocytic (GOIs GAIs). Occurrence of neuronal cytoplasmic (NCIs) also feature. GGT classified into three pathological subtypes (Types I, II III). We studied tau pathology in 6 cases (Type II, n = 3; Type III, 3), with special reference to GAIs NCIs. Methods Neuropathological examinations were...
Bromperidol is a close structural analog of haloperidol. The authors studied the effects levomepromazine and thioridazine, which are frequently added to other neuroleptics as sedatives, on plasma concentrations bromperidol its reduced metabolite. subjects were 26 inpatients with schizophrenia receiving bromperidol, 12 24 mg/day, for 1 19 weeks. In 10 cases, 50 mg per day in nine thioridazine coadministered week. seven both drugs ≥2-week intervals. Plasma measured by high-performance liquid...