A5067205197- Cutaneous lymphoproliferative disorders research
- Cancer and Skin Lesions
- Autoimmune Bullous Skin Diseases
- Nail Diseases and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- CAR-T cell therapy research
- Drug-Induced Adverse Reactions
- Colorectal Cancer Treatments and Studies
- Melanoma and MAPK Pathways
- Cancer Immunotherapy and Biomarkers
- Skin and Cellular Biology Research
- Cutaneous Melanoma Detection and Management
- Contact Dermatitis and Allergies
- Urticaria and Related Conditions
- Hedgehog Signaling Pathway Studies
- Nonmelanoma Skin Cancer Studies
- RNA regulation and disease
- Fungal Infections and Studies
- Psoriasis: Treatment and Pathogenesis
- Cancer Diagnosis and Treatment
- Hair Growth and Disorders
- Autoimmune and Inflammatory Disorders
- Chemotherapy-related skin toxicity
- Histiocytic Disorders and Treatments
- Genetic and rare skin diseases.
Tokyo Metropolitan Komagome Hospital
2023-2024
Japanese Foundation For Cancer Research
2021-2023
The Cancer Institute Hospital
2018-2023
Tohoku University
2022
National Defense Medical College
2016-2021
Tokyo Medical and Dental University
2008-2020
National Defense Medical College Hospital
2018-2019
National Cancer Center Hospital East
2018
Advanced Dermatology
2016
Hirosaki University
2005-2010
The E-cadherin-mediated cell adhesion system is frequently inactivated by multiple mechanisms and involved in tumor progression many types of cancer. Recently, the authors reported a novel membrane glycoprotein, dysadherin, which has an anti-cell-cell function down-regulates E-cadherin.Expression both dysadherin E-cadherin was investigated immunohistochemically 115 patients with cutaneous malignant melanoma to determine correlation between 2 molecules their associations patient survival...
Currently, only a few reports exist on the cytokine release syndrome (CRS) as one of severe immune-related adverse events (irAEs) induced by immune checkpoint inhibitors (ICIs). Notably, it is very rare that grade 4 CRS related to ICI therapy overlaps with drug-induced hypersensitivity (DiHS). A 46-year old woman metastatic kidney cancer had 3 interstitial pneumonitis four cycles combination anti-programmed death-1 and anti-cytotoxic T lymphocyte-4 antibodies after right cytoreductive...
Background: Skin toxicity is a common adverse event during cetuximab (Cmab) treatment. However, few reports have investigated the correlation between skin and efficacy of Cmab in patients with recurrent or metastatic squamous cell carcinoma head neck (R/M SCCHN). Methods: We retrospectively reviewed 112 R/M SCCHN who received palliative chemotherapy Cmab. Main eligibility criteria included primary disease oral cavity, hypopharynx, nasopharynx, oropharynx, larynx; no prior history...
Conflicts of interest: none declared. Cowden syndrome (CS; OMIM 158350) is a rare genetic disorder that characterized by multiple hamartomas (affecting various organs derived from all three germ layers) and an increased risk some cancers, in particular thyroid breast cancers.1 The lifetime risks for cancer are estimated to be 3–10% 25–50%, respectively.1 Characteristic mucocutaneous manifestations include facial trichilemmomas, oral mucosal papillomatoses acral keratoses. These clinical...
Nevus sebaceous is known by its association with one or more secondary tumors, but than three multiple tumors arising from a nevus extremely rare. A 67-year-old female presented light brown plaque on the back of her head that contained dome-shaped black node and an erosive lesion. Histopathological examination showed atypical basaloid cells in node. At periphery node, structures resembling follicular germs extruded interlacing cords upper portion tumor nests sebocytes were lower portion. In...
Background Novel therapies, immune checkpoint inhibitors (ICIs), and BRAF/MEK (BRAFi/MEKi) provide unprecedented survival benefits for patients with advanced melanoma. However, the management of drug-induced adverse events is problematic both agents and, although rare, can cause serious cardiac dysfunction. Case report A 42-year-old male patient no significant medical history noticed a fading dark brown patch on his left anterior chest, which had been there 20 years, after second coronavirus...
Psoriasis is considered to be a disease mediated by Th17/Th1 immunity, with the production of interleukin (IL)-17, IL-22, and interferon (IFN)-γ. Previous evidence has also demonstrated possible involvement epidermal growth factor receptor (EGFR) ligands vascular en-dothelial (VEGF) (1–5). Panitumumab human monoclonal antibody targeting EGFR. On other hand, bevacizumab humanized that binds VEGF. Here, we observed clinical effects these antibodies administered for rectal cancer in patient...
Abstract Background Lichen planus (LP) is a common skin disorder of unknown aetiology that affects the skin, mucous membranes and nails. Although metal allergies have been implicated in development oral LP (OLP), contribution these to nail (NLP) has yet be studied detail. Objective To elucidate link between allergy NLP. Methods We retrospectively analysed 115 patients with respect metals either NLP or OLP. also attempted detect specific involved lesions. Results Of 79 received patch test...
Recently, an enzyme-linked immunosorbent assay (ELISA) using prothrombin (PT) as the antigen has become a widely used test. Two ELISA methods for detection of antiprothrombin antibody have been extensively: one method employs PT (aPT), and other phosphatidyl serine (aPT/PS) antigens along with Ca. However, results obtained by two are not necessarily consistent each even same samples, suggesting possibility that aPT aPT/PS different antibodies. We conducted investigation to determine whether...
Photodynamic therapy (PDT) with topical application of 5-aminolaevulinic acid (ALA) is a promising new treatment option for the management various cutaneous malignancies. Generally, ALA-based PDT has relatively insignificant adverse effects transient character; these include itching, stinging or burning pain and slight to moderate erythema. We describe first case photocontact urticaria induced by unilesional mycosis fungoides. Although session resulted merely in mild erythema, second caused...
Several studies have analyzed the relationship between androgenetic alopecia and cardiovascular disease (mainly heart disease). However few lipid values in men women separately. This case-control study included 300 patients consecutively admitted to an outpatient clinic, 150 with early onset (80 males 70 females) controls other skin diseases. Female androgenic showed significant higher triglycerides (123.8 vs 89.43 mg/dl, p=0.006), total cholesterol (196.1 182.3 p=0.014), LDL-C (114.1 98.8...
A 62-year-old Japanese woman presented with left lower abdominal swelling and redness tenderness in October 2012. The patient had diabetes mellitus requiring insulin therapy, she her parents a history of pulmonary tuberculosis. She myasthenia gravis since 2003, an extended thymectomy been performed for thymoma. During the administration prednisolone (35 mg/day) tacrolimus (4 post-operative thymoma July 2012, was diagnosed adult-onset Still's [...]
Muir-Torre syndrome (MTS) is an autosomal, dominantly inherited disorder characterized by sebaceous neoplasms and visceral malignancies. We report a 56-year-old woman who underwent resections of extraocular carcinoma, epithelioma, actinic keratosis, keratoacanthoma (KA)-like squamous cell carcinoma (SCC) with venous invasion metachronously over 9-year period. Because the mixed, unusual features skin lesions, her history endometrial colorectal cancers that had been resected 12 years 1 year,...
Journal Article Novel and recurrent nonsense mutation of the SLC39A4 gene in Japanese patients with acrodermatitis enteropathica Get access H. Nakano, Nakano Department Dermatology, Hirosaki University Graduate School Medicine, 5 Zaifu‐cho, 036‐8562, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Nakamura, Nakamura Faculty Yamanashi, T. Kawamura, Kawamura N. Shibagaki, Shibagaki Matsue, Matsue Chiba Chiba, Aizu, Aizu D. Rokunohe, Rokunohe E. Akasaka,...
Conflicts of interest: none declared. Ichthyosis bullosa Siemens (IBS) is a rare autosomal dominant skin disorder characterized by blister formation in the upper suprabasal layers epidermis. Clinical features disease, which include blistering after mechanical trauma, lichenified hyperkeratosis over flexural areas limbs, and superficial peeling skin, are similar to those epidermolytic hyperkeratosis/bullous congenital ichthyosiform erythroderma (EHK/BCIE). This clinical resemblance makes...
B16-F1 melanoma cells have often been used as a model to investigate melanogenesis, but the evidence that melanosome biogenesis and transport occur by same mechanisms in normal melanocytes is insufficient. In this study, we established knockout for each of several key factors i.e., tyrosinase (Tyr), Hps4, Rab27A, Rab32·Rab38 (Rab32/38), then compared their phenotypes with corresponding mutant mouse melanocyte cell lines, melan-c, melan-le, melan-ash, Rab32-deficient melan-cht cells,...