A5009768534- Nonmelanoma Skin Cancer Studies
- Melanoma and MAPK Pathways
- Cancer and Skin Lesions
- Cancer Immunotherapy and Biomarkers
- Cutaneous Melanoma Detection and Management
- Cutaneous lymphoproliferative disorders research
- Vascular Tumors and Angiosarcomas
- Autoimmune Bullous Skin Diseases
- Sarcoma Diagnosis and Treatment
- Nail Diseases and Treatments
- Peptidase Inhibition and Analysis
- Chemotherapy-related skin toxicity
- Hedgehog Signaling Pathway Studies
- Colorectal Cancer Treatments and Studies
- Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Teratomas and Epidermoid Cysts
- Hair Growth and Disorders
- Cardiac tumors and thrombi
- Palliative Care and End-of-Life Issues
- Cancer Research and Treatments
- Reconstructive Surgery and Microvascular Techniques
- HER2/EGFR in Cancer Research
- Urticaria and Related Conditions
- Protein Degradation and Inhibitors
Shinshu University
2015-2023
Ōtani University
2022
Shizuoka Cancer Center
2015-2019
Shinshu University Hospital
2017
Nagano Municipal Hospital
2013
Cutaneous adverse events are relatively common in patients being treated with molecular-targeted drugs. Paronychia is one of the cutaneous that influences patient's quality life because pain, and it often affects anticancer treatments severe cases. However, there few effective treatments, especially for paronychia. Here, we present our experiences treatment paronychia due to oncology pharmacotherapy. Although various methods, only corticosteroid ointment phenol chemical matricectomy...
A cutaneous metastatic tumor is relatively rare, and patients with such a usually have poor prognosis. Even if the metastases can be treated, treatment cannot improve However, neglecting lesions sometimes results in great deterioration of quality life. Cutaneous foci are generally treated chemotherapy and/or radiotherapy. On other hand, surgical chosen for metastases. In this study, we analyzed data 40 tumors who received at Shizuoka Cancer Center between January 2009 August 2014. Among...
Abstract Skin grafting is a simple method for reconstruction of large defect on the foot. Although skin foot sometimes fails, it not clear what factors influence success rate grafting. We analyzed data 71 patients with cancer who underwent defects The we evaluated were grafting, weight‐bearing or non‐weight‐bearing area, immediate delayed reconstruction, and whether tie‐over bolster was used not. rates higher in lesions areas than received reconstruction. On other hand, use did improve rate....
Knowledge of the prevalence symptoms in patients with incurable cancer terminal stage is important for clinicians. However, there has been no report on skin cancer. We analyzed 224 who died due to our center. These data were obtained from medical records compiled by a miscellaneous population staff retrospectively. evaluated at 3 months, 1 month, 2 weeks, week and days before died. Data included Eastern Cooperative Oncology Group performance status presence or absence following 13 symptoms:...
Abstract Along with the expansion of therapeutic options for metastatic melanoma, development useful biomarkers is urgently required to predict and monitor treatment response. Serum 5‐ S ‐cysteinyldopa (5‐ ‐ CD ) has been identified as a diagnostic marker malignant but its utility biomarker emerging agents remains unknown. We assessed serum in 12 melanoma patients (median age, 76 years; six men women) who had treated nivolumab (Nivo) at Shinshu University Hospital between 2014 2016. lactate...
Pineal cysts are a common incidental finding in imaging studies, and the majority of such asymptomatic. However, hemorrhaging pineal cysts, which considered to be rare, often associated with severe symptoms. We herein describe case 58-year-old patient novel manifestation bleeding cyst, who had benign outcome without any surgical treatment. Although clinical manifestations resembled those bacterial meningitis, magnetic resonance images suggested chemical meningitis caused by an intracystic...
Squamous cell carcinoma (SCC) is a common skin cancer that may be associated with ultraviolet ray exposure, scarring due to trauma or burn, chronic osteomyelitis [1, 2]. SCC usually treated by surgery. However, for of the lower legs, surgery sometimes problematic; indeed, tumour cells easily infiltrate tibia lack protective fat buffer layer at front leg. Amputation safe method resecting tumour, and management wound after [...]
Abstract Basal cell carcinoma is the most common type of skin cancer, and surgical excision with clear margins standard care. Surgical are determined based on risk factors (high or low risk) for recurrence according to National Comprehensive Cancer Network Japanese basal guidelines. The clarity clinical tumor border (well‐defined poorly defined) considered a factor, significant discrepancies in judgment borders among dermato‐oncologists may occur. Therefore, we analyzed dermato‐oncologists’...
None declared.
TPS9604 Background: Basal cell carcinomas (BCCs), the most common type of skin cancer, frequently occur on head and neck. Because distant metastases are extremely rare, complete excision with clear margins is standard treatment for BCCs. In NCCN Guidelines, recommended surgical strategies include wider ( > 4 mm) or Mohs surgery other forms peripheral deep en face margin assessment (PDEMA) neck However, these based studies in Caucasian population, BCCs mostly arising as non-pigmented...
In this report, we present a case of cardiac metastasis malignant melanoma originating from the nasal cavity and presenting with tamponade detected during immunotherapy. The patient was 66-year-old man diagnosed right 4 years ago. Two ago, size increased making it unresectable; therefore, he treated thrice combination therapy nivolumab ipilimumab. Subsequently, treatment changed to single-agent therapy, which continuously administered for one half years. Imaging evaluation conducted every 3...
症例は26歳，女性。初診の約 2 週間前から左腰部の腫脹と疼痛が出現した。症状は徐々に増悪し，同部から排膿があったため当科を受診した。左腰部に熱感と圧痛を伴う 10 cm 大の紅斑性の腫脹を認めた。 紅斑の中央部からは，黄白色の膿と糞便状の液体が排出されていた。発熱はなく，腹部所見に異常を認めなかった。血液生化学検査では C 反応性蛋白の上昇を認めた。排出された膿の細菌培養検査では Escherichia coli と Streptococcus anginosus を検出した。腹部造影 CT 検査と MRI 検査において皮膚と結腸の間に瘻孔が認められ，結腸皮膚瘻による皮下膿瘍と診断した。当院外科で，ドレナージと抗生剤の投与が行われた。注腸造影検査では下行結腸の狭窄と同部から皮膚への瘻孔を認め，大腸内視鏡検査で下行結腸の狭窄と敷石状所見を認めた。臨床経過と検査所見から Crohn 病に伴う結腸皮膚瘻と診断した。抗 TNFα...
症例1:50代女性。症例2:40代女性。症例3:60代女性。初診の2~5年前から陰部に痒みやびらんの自覚があり,小陰唇または大陰唇に2~4 cm大の結節を生じた。いずれも周囲の外陰部粘膜に白色硬化性の変化を伴っていた。生検で結節部は有棘細胞癌(SCC)の所見であったため,全摘を実施した。腫瘍周囲の皮膚には表皮の萎縮,表皮真皮境界部の液状変性,真皮浅層のリンパ球浸潤,膠原線維の膨化・増生などを認めたことから,硬化性萎縮性苔癬(LSA)に生じたSCCと診断した。外陰部のLSAはSCCの発生母地になり得る。本邦からの報告をまとめたところ,LSAを発症してからSCCと診断されるまでの年数は1~30年と幅があった。また,残存LSAからのSCCの再発の報告も存在した。SCCの再発防止およびLSAの症状緩和目的に,QOLを保つ範囲でLSAも可能な限り同時に切除するのが望ましいと考えた。またLSAを完全切除した場合も,長期的な経過観察が必要である。
e21068 Background: Despite considerable advances in the treatment of metastatic melanoma, reliable markers to monitor response are still lacking. 5-S-cysteinyldopa (5-S-CD) is a precursor melanin that has been established as biomarker for melanoma progression. This study evaluated serum 5-S-CD parallel with lactate dehydrogenase (LD) predictor progress patients receiving Nivolumab (Nivo) therapy. Materials and Methods: Twenty-one (median age: 77 years; 10 male 11 female) who were treated...