A5079144383- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Developmental Biology and Gene Regulation
- Cancer and Skin Lesions
- NF-κB Signaling Pathways
- Autoimmune Bullous Skin Diseases
- Corneal Surgery and Treatments
- Immune Response and Inflammation
- Cancer-related Molecular Pathways
- Cutaneous lymphoproliferative disorders research
- Melanoma and MAPK Pathways
- Spondyloarthritis Studies and Treatments
- Immune Cell Function and Interaction
- Rheumatoid Arthritis Research and Therapies
- Cutaneous Melanoma Detection and Management
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Enzyme function and inhibition
- Urticaria and Related Conditions
- Horticultural and Viticultural Research
- Trace Elements in Health
- Asthma and respiratory diseases
- Epigenetics and DNA Methylation
- Autoimmune and Inflammatory Disorders Research
- Fibroblast Growth Factor Research
Shinshu University
2014-2023
Ōtani University
2017-2020
Nagoya University
2017
Shinshu University Hospital
2012-2013
Tohoku University
2004-2010
Kōchi University
2003
Kyoto University
2002
We observed a consistent eye-open at birth (EOB) phenotype in mouse pups homozygous for leucine-rich repeat containing G-protein coupled receptor 4 (Lgr4) allele deleting the whole transmembrane domain coding region. An vitro wound-healing scratch assay showed notably reduced keratinocyte motility null mice. Phalloidin staining of F-actin eyelid epidermis was also reduced. generated keratinocyte-specific Lgr4 deficient mice, circumventing embryonic/neonatal lethality and kidney...
Immune cell Toll-like receptors (TLRs) recognize conserved microbial components, leading to immune and inflammatory responses. However, TLRs are also expressed in cancer cells, including melanoma which express TLR2-4. TLR4 ligands have received attention as immunotherapies; therefore, we assessed the expression of human specimens (29 primary lesions 28 metastatic lesions) representing different types melanoma. A high percentage (≥ 90%) TLR4, judged by immunohistochemistry. Next, role...
Objective: Brain natriuretic peptide (BNP) is a cardiac hormone mainly synthesized in ventricles and its expression markedly increased ventricular hypertrophy that involves the accumulation of extracellular matrix proteins, such as fibronectin (Fn). We recently reported Fn signaling stimulated BNP secretion accompanied by hypertrophic responses vitro. Methods: To elucidate regulatory mechanism for gene transcription, we examined cis-acting elements downstream rat myocytes transfected with...
p63/p51, a homolog of the tumor suppressor protein p53, is chiefly expressed in epithelial tissues, including epidermis. p63 affects cell death similar to and also plays important roles development tissues maintenance stem cells. Because it remains unclear how regulates differentiation, we examined function(s) keratinocyte differentiation through use culture system. DeltaNp63alpha (DeltaNp51B), isoform specifically basal keratinocytes, suppressed specific late-stage proteins, such as...
Bach1 is a member of the basic leucine zipper transcription factor family, and Bach1/small Maf heterodimer specifically represses transcriptional activity directed by recognition element (MARE). Because repressor oxidative stress response, we examined function(s) in keratinocytes subjected to stress. Oxidative induced H(2)O(2) led an increase MARE expression heme oxygenase-1 (HO-1), inducible antioxidant defense enzyme. depletion small interfering RNAs or deletion enhanced HO-1 absence...
Abstract A local epidemiological survey of psoriasis was conducted from 19 February to 30 June 2016 in Matsumoto city, Nagano Prefecture, Japan. Patients were predominantly male (268 cases, 71.5% males vs 107 28.5% females). We estimated that the prevalence 0.097% area. The clinical types identified vulgaris (90.7%), psoriatic arthritis (5.9%), pustular (2.1%), guttate (1.0%) and erythroderma (0.3%). topical therapeutic agents included corticosteroids (84.0%), vitamin D 3 analogs (61.5%), a...
Abstract Characteristic odour components of Citrus inflata Hort. ex Tanaka (Mochiyu) were studied by sensorial and instrumental techniques. Flavour dilution (FD) factor relative flavour activity (RFA) individual volatile evaluated aroma extraction analysis (AEDA) gas chromatography–olfactometry (GC–O). The results indicated that hydrocarbons (98.1%) made up most the oil: monoterpenes sesquiterpenes 97.6% 0.5%, respectively. Among oxygenated compounds, linalool (0.2%) as an alcohol,...
The Runt-related transcription factor (Runx) family has been suggested to play roles in stem cell regulation, tissue development, and oncogenesis various tissues/organs. In this study, we investigated the possible functions of Runx1 Runx3 keratinocyte differentiation. Both proteins were detected primary cultures mouse keratinocytes. Proteins localized nuclei undifferentiated keratinocytes but translocated cytoplasm differentiated cells. siRNA-mediated inhibition expression increased keratin...