A5101678028- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic factors in colorectal cancer
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metastasis and carcinoma case studies
- Diverticular Disease and Complications
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Surgical Treatments
- Peptidase Inhibition and Analysis
- Cytokine Signaling Pathways and Interactions
- Gallbladder and Bile Duct Disorders
- Cell Adhesion Molecules Research
- Liver Disease Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Sarcoma Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Cancer Mechanisms and Therapy
- Cancer Diagnosis and Treatment
- Intraperitoneal and Appendiceal Malignancies
University of Occupational and Environmental Health Japan
2024
NTT Medical Center
2012-2024
Sapporo Medical University
2010-2023
Fukushima Medical University
2019-2023
Johnson & Johnson (United States)
2023
Fukushima Medical University Hospital
2023
Nippon Medical School
2018-2023
Janssen (United States)
2023
Josai University
2023
Tobishima (Japan)
2023
Individual plasma proteins have been identified as minimally invasive biomarkers for lung cancer diagnosis with potential utility in early detection. Plasma proteomes provide insight into contributing biological factors; we investigated their future prediction.The Olink® Explore-3072 platform quantitated 2941 496 Liverpool Lung Project samples, including 131 cases taken 1-10 years prior to diagnosis, 237 controls, and 90 subjects at multiple times. 1112 significantly associated haemolysis...
TAZ (transcriptional coactivator with PDZ-binding motif), also called WWTR1 (WW domain containing transcription regulator 1), is a 14-3-3-binding molecule homologous to Yes-associated protein. acts as for several factors well modulator of membrane-associated PDZ domain-containing proteins, but its (patho)physiological roles remain unknown. Here we show that gene inactivation in mice resulted pathological changes the kidney and lung resemble common human diseases polycystic disease pulmonary...
Esophageal adenocarcinoma arises from Barrett's esophagus, which is induced by gastro-esophageal reflux. This refluxate often contains duodenal contents, whose backflow triggers gastric carcinoma, suggesting the hypothesis that refluxed contents cause esophageal carcinoma. study examines role of and reflux in absence exogenous carcinogens carcinogenesis. Wistar male rats, 120 all, each weighing approximately 250 g, were used. Three experimental procedures performed to produce...
Abstract Dnm3os , a gene that is transcribed into non‐coding RNA (ncRNA), contains three micro RNAs (miRNAs), miR‐199a, miR‐199a*, and miR‐214, whose functions remain unknown in mammals. In this study, we introduced the lacZ locus to recapitulate its expression pattern disrupt function. +/ heterozygous embryos showed β‐galactosidase activity, which reflected authentic of RNA. Most / homozygous pups died within one month birth. After birth, mice exhibited several skeletal abnormalities,...
Two human epithelial cell lines, trophoblastic teratocarcinoma HT-H and endometrial adenocarcinoma SNG-M cells, adhere to each other at their respective apical surfaces in a divalent cation-independent manner. novel molecules responsible for the adhesion between these two types were identified by expression cDNA cloning. One, named trophinin, is an intrinsic membrane protein mediates homophilic self-binding. Another, tastin, cytoplasmic necessary trophinin function as molecule. Trophinin...
Background NKG2D is an activating receptor expressed by natural killer and T cells, which have crucial functions in tumor microbial immunosurveillance. Several cytokines been identified as modulators of expression. However, little known about gene regulation. In this study, we found that microRNA 1245 attenuated the expression cells.Design Methods We investigated potential interactions between 3′-untranslated region well their functional roles regulation cytotoxicity cells.Results...
Epigenetic drugs, such as DNA methylation inhibitors (DNMTi) or histone deacetylase (HDACi), are approved in monotherapy for cancer treatment. These drugs reprogram gene expression profiles, reactivate tumor suppressor genes (TSG) producing cell differentiation and apoptosis. have been shown to synergize with other epigenetic various anticancer drugs. To discover new molecular entities that enhance therapy, we performed a high-throughput screening using FDA-approved libraries combination...
Abstract AT-rich interactive domain 1A ( ARID1A ) functions as a tumor suppressor and several therapeutic targets in -mutated cancers are under development. Here, we investigated the prognostic value of for gastric cancer its association with expression PD-L1 p53. was examined by immunohistochemistry negative detected 39 (19.5%) 200 cases test cohort 40 (18.2%) 220 validation cohort. Negative associated worse overall survival undifferentiated cases, particularly early-stage cases. 11 (50%)...
Abstract Background Prurigo nodularis (PN), a chronic inflammatory skin condition, adversely affects the quality of life affected individuals. Current treatment options for PN in Japan are limited. Objectives To evaluate optimal dose, efficacy and safety long-term with nemolizumab patients Japan. Methods In 16-week double-blind phase II/III study, aged ≥ 13 years were randomly assigned (1 : 1 1) to 30-mg, 60-mg or placebo groups, concomitant topical corticosteroids, every 4 weeks. The...
Calpains are Ca2+-dependent modulator Cys proteases that have a variety of functions in almost all eukaryotes. There more than 10 well-conserved mammalian calpains, among which eutherian calpain-6 (CAPN6) is unique it has amino acid substitutions at the active-site residue (to Lys humans), strongly suggesting loss proteolytic activity. CAPN6 expressed predominantly embryonic muscles, placenta, and several cultured cell lines. We previously reported involved regulating microtubule dynamics...
The endothelin (Edn) system comprises three ligands (Edn1, Edn2 and Edn3) their G-protein-coupled type A (Ednra) B (Ednrb) receptors. During embryogenesis, the Edn1/Ednra signaling is thought to regulate dorsoventral axis patterning of pharyngeal arches via Dlx5/Dlx6 upregulation. To further clarify underlying mechanism, we have established mice in which gene cassettes can be efficiently knocked-in into Ednra locus using recombinase-mediated cassette exchange (RMCE) based on Cre-lox system....
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of new heparinoids with high anticoagulant activityKenichi Hatanaka, Takashi Yoshida, Shintaro Miyahara, Takahiro Sato, Fujihiko Ono, Toshiyuki Uryu, and Hiroyoshi KuzuharaCite this: J. Med. Chem. 1987, 30, 5, 810–814Publication Date (Print):May 1, 1987Publication History Published online1 May 2002Published inissue 1 1987https://pubs.acs.org/doi/10.1021/jm00388a011https://doi.org/10.1021/jm00388a011research-articleACS PublicationsRequest...
In laboratory mice and rats, congenic breeding is essential for analyzing the genes of interest on specific genetic backgrounds quantitative trait loci. However, in theory it takes about 3-4 years to achieve a strain carrying 99% recipient genome at tenth backcrossing (N10). Even with marker-assisted selection, so-called 'speed strategy', more than year N4 or N5.Here we describe new high-speed system using round spermatids retrieved from immature males (22-25 days age). We applied technique...
TGFβ signaling in the tumor microenvironment (TME) drives immune evasion and is a negative predictor of checkpoint inhibitor (ICI) efficacy colorectal cancer (CRC). TIM-3, an inhibitory receptor implicated anti-tumor responses ICI resistance, has emerged as immunotherapeutic target. This study investigated M2 macrophages TGFβ-activated TME, association with microsatellite instability (MSI) status consensus molecular subtypes (CMSs). Transcriptomic cohorts CRC tissues, organoids xenografts...
Background Intake of retinoic acid (RA) or its precursor, vitamin A, during early pregnancy is associated with increased incidence craniofacial lesions. The origin these teratogenic effects remains enigmatic as in cranial neural crest cells (CNCCs), which largely contribute to structures, the RA-transduction pathway not active. Recent results suggest that RA could act on endoderm first pharyngeal arch (1stPA), through a RARß-dependent mechanism. Methodology/Principal Findings Here we show...