A5037767129- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Contact Dermatitis and Allergies
- Autoimmune Bullous Skin Diseases
- Exercise and Physiological Responses
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Diagnosis and Treatment of Venous Diseases
- Venous Thromboembolism Diagnosis and Management
- Asthma and respiratory diseases
- Dermatologic Treatments and Research
- Eosinophilic Disorders and Syndromes
- Dermatology and Skin Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Muscle metabolism and nutrition
- Dermatological and COVID-19 studies
- Cardiovascular and exercise physiology
- Cutaneous lymphoproliferative disorders research
- Vector-borne infectious diseases
- Pharmacovigilance and Adverse Drug Reactions
- Cutaneous Melanoma Detection and Management
- Adipose Tissue and Metabolism
- Nonmelanoma Skin Cancer Studies
- Cancer and Skin Lesions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Shimane University
2015-2025
Shimane University Hospital
2014-2019
Waseda University
2013-2016
Japan Society for the Promotion of Science
2016
Creative Commons
2016
Juntendo University
2016
Keio University
1968
Summary Background Food‐dependent exercise‐induced anaphylaxis (FDEIA) is an allergic reaction characteristically induced by intense exercise combined with the ingestion of causative food. Recent reports have shown that aspirin intake a contributing factor in some patients FDEIA. Wheat known to be most frequent food, and IgE‐binding epitopes major wheat allergen (ω‐5 gliadin) wheat‐dependent (WDEIA) already been clarified. However, mechanism eliciting symptom WDEIA remains not fully...
Abstract Wheat ω-5 gliadin and a high m.w. glutenin subunit (HMW-glutenin) have been reported as major allergens in wheat-dependent exercise-induced anaphylaxis. A simultaneous detection of specific IgE to epitope sequences both proteins is considered be reliable method for diagnosis However, the IgE-binding HMW-glutenin remains unknown. The aim this study was determine epitopes establish useful system identifying patients with For determination overlapping peptides were synthesized...
To cite this article: Morita E, Takahashi H, Niihara Dekio I, Sumikawa Y, Murakami Matsunaka H. Stratum corneum TARC level is a new indicator of lesional skin inflammation in atopic dermatitis. Allergy 2010; 65 : 1166–1172. Abstract Background: Management dermatitis (AD) requires judging the symptoms local lesions and prescribing suitable treatment. However, no method has been established which objective measures can be used to evaluate severity symptoms. We for measuring thymus...
Purpose The infiltration of macrophages in skeletal muscle during exhaustive exercise promotes inflammation, myofiber lesion, and injury. Although neutrophils upregulate macrophage muscles exercise, the role promoting injury after remains unclear. In this study, we investigated effects preexercise neutrophil depletion with antineutrophil antibody treatment on injury, exercise. Methods Male C57BL/6J mice were randomly assigned to four groups, namely, sedentary control (n = 10), 10). given...
Abstract Drug‐induced hypersensitivity syndrome (DIHS) is one of the severe drug eruptions accompanied by fever and multiple organ dysfunction, it induced a relatively limited range drugs, including anticonvulsants. A distinctive feature this condition its association with reactivation herpes viruses, particularly human herpesvirus 6. The pathogenesis involves two key factors: allergy reactivation. DIHS often challenging to diagnose in early stages, clinical course varies widely, ranging...
Abstract The concept of immune reconstitution inflammatory syndrome (IRIS) has recently been applied to patients with non‐HIV infection fluctuations. However, quantitative criteria diagnose IRIS have not established. Similarly, immune‐related adverse events (irAEs) caused by checkpoint inhibitors (ICIs) are also No study directly compared the immunological indicators and irAEs. Thus, we investigated whether irAEs can be included in IRIS. We aimed search for diagnostic biomarkers compare...
ABSTRACT The radioisotope navigation method, which has usually been used for identification of sentinel nodes, is less useful in locating nodes close to primary lesions cases extramammary Paget's disease because overlapping radioactivity from the site. We applied fluorescence with indocyanine green (ICG) two patients skin cancer cover this defect. use a charge‐coupled device camera enabled real‐time visualization dynamic lymph flow without incision. inguinal over identified node handheld...
Challenge testing with wheat plus exercise and/or aspirin is a gold standard for the diagnosis of wheat-dependent exercise-induced anaphylaxis (WDEIA); however, test may often yield false-negative results. Our previous study suggested that an increase in serum gliadin levels required to induce allergic symptoms patients WDEIA. Based on this knowledge, we sought extract false negative results challenge tests WDEIA.Thirty-six suspected WDEIA were enrolled. First, group categorizations-Group I,...
Exhaustive exercise promotes muscle injury, including myofiber lesions; however, its exact mechanism has not yet been elucidated. In this study, we tested the hypothesis that macrophage depletion by pretreatment with clodronate liposomes alters injury and inflammation following exhaustive exercise. Male C57BL/6J mice were divided into four groups: rest plus control liposome (n=8), (n=8). Mice treated or for 48 h before undergoing on a treadmill. Twenty-four hours after exercise,...
The innate immune system is associated with the development of local inflammation. Neutrophils play an essential role in adipose tissue (AT) inflammation obesity by producing elastase, which can promote activation and infiltration macrophages. Exercise training attenuates AT via suppression macrophage infiltration. However, mechanisms driving this phenomenon remains to be elucidated. Here, we evaluated effects exercise on neutrophils elastase expression obese mouse model. Four-week-old male...
This study aims to evaluate the relationship between serum thymus and activation-regulated chemokine (TARC) levels with various clinicopathological conditions in patients drug eruptions. The value of TARC diagnosing drug-induced hypersensitivity syndrome (DIHS) was also examined.Study participants included 84 who presented generalized eruptions suspected be drug-related, including DIHS, Stevens-Johnson (SJS)/toxic epidermal necrolysis (TEN), maculopapular exanthema (MPE), erythema multiforme...
In severe drug eruptions, precise evaluation of disease severity at an early stage is needed to start appropriate treatment. It not always easy diagnose these conditions their stage. addition, there are no reported prognostic biomarkers in eruptions. The aim this study was test whether the thymus and activation-regulated chemokine (TARC) level serum a eruption can serve as biomarker systemic inflammation. Study participants included 76 patients who received diagnosis eruption, one following:...
Varicose veins (VV) in legs are commonly observed the general global population. However, prevalence of and risk factors for VV Japan not clear. This study aimed at clarifying traditional rural areas Shimane prefecture. Subjects (113 men 205 women aged ≥45 years) were recruited from health examinations those 2012. defined as a reflux blood great and/or small saphenous vein incompetent perforating detected by ultrasonography. Risk analyzed using logistic regression models that included...
Drug-induced hypersensitivity syndrome (DIHS), also referred to as drug reaction with eosinophilia and systemic symptoms (DRESS), is a multi-organ characterized by hematological abnormalities reactivation of human herpesvirus-6 (HHV-6). DIHS/DRESS typically associated limited number drugs, such the anticonvulsants. Our group has treated 12 patients for due lamotrigine (LTG), but their presentation differed from that caused other drugs. The aim present study was identify significant...
Objectives To clarify the surgical methods and clinical results of subfascial endoscopic perforator surgery in Japan. Methods This study included 1287 limbs 1091 patients who underwent 14 hospitals. Simultaneous saphenous vein treatment was performed 1079 (83.8%), 118 (9.2%) had deep venous lesions. The severity score calculated before 6 to 12 months after surgery. ulcer healing rate recurrence were cumulatively. Results Preoperative significantly decreased from 10.0 ± 6.6 3.1 3.4 ( P <...
The effect of alcohol intake on varicose veins (VV) has not been determined by its consumption level. aim this study was to investigate the association between and VV in an elderly general population. Using a cross-sectional approach, Shimane CoHRE Study data, comprising total 1060 participants, were analyzed. By multivariate regression analysis adjusted with basic characteristics, past work history, lifestyle-related factors medical compared non-drinkers, mild drinkers (<20.0 g/day) showed...