A5046548431- Dermatology and Skin Diseases
- Acne and Rosacea Treatments and Effects
- Oral Health Pathology and Treatment
- Allergic Rhinitis and Sensitization
- Nail Diseases and Treatments
- Contact Dermatitis and Allergies
- Food Allergy and Anaphylaxis Research
- Genetic and rare skin diseases.
- Oral microbiology and periodontitis research
- Genomics and Phylogenetic Studies
- Autoimmune and Inflammatory Disorders
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Cutaneous Melanoma Detection and Management
- Cancer and Skin Lesions
- Microbial Metabolism and Applications
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Pharmacological Effects of Natural Compounds
- Herpesvirus Infections and Treatments
- Infectious Diseases and Mycology
- Cutaneous lymphoproliferative disorders research
- Hidradenitis Suppurativa and Treatments
- Nonmelanoma Skin Cancer Studies
- Soft tissue tumor case studies
Jikei University School of Medicine
2021-2024
Keio University
2005-2021
RIKEN BioResource Research Center
2007-2020
Tokyo Women's Medical University Adachi Medical Center
2014-2018
Public Health England
2015-2016
Nottingham Trent University
2013
Shimane University
2009-2012
Tsuda University
2012
Keio University Hospital
2008
Sapporo Kosei General Hospital
2003
Although the micro-organisms forming cutaneous microbiota are considered to play important roles in modification and prevention of skin diseases, a comprehensive analysis their composition has not yet been carried out because difficulties determining yet-to-be-cultured samples. Swab-scrubbed forehead samples five healthy volunteers were analysed by profiling 16S rRNA genes, as well conventional culture methods, provide profile that included bacteria from normal human skin. Cluster analyses...
Propionibacterium acnes subsp. nov. and elongatum are described. These emanate from the three known phylotypes of P. acnes, designated types I, II III. Electron microscopy confirmed filamentous cell shape type III, showing a striking difference I/II, which were short rods. Biochemical tests indicated that, in either pyruvate, l-pyrrolidonyl arylamidase or d-ribose 2 test was positive, whereas all these negative among III strains. Matrix-assisted laser-desorption/ionization time-of-flight...
A previous study using bacterial 16S rRNA gene-based clone libraries revealed that the microbiota in healthy human skin included uncultured micro-organisms, although micro-organisms exposed to disease conditions remain be examined. To compare profiles of 13 patients with atopic dermatitis (AD) and 10 controls, terminal RFLP analysis genes was applied 23 swab-scrubbed samples from facial skin. This culture-independent successfully complex members as peak patterns following capillary...
To cite this article: Morita E, Takahashi H, Niihara Dekio I, Sumikawa Y, Murakami Matsunaka H. Stratum corneum TARC level is a new indicator of lesional skin inflammation in atopic dermatitis. Allergy 2010; 65 : 1166–1172. Abstract Background: Management dermatitis (AD) requires judging the symptoms local lesions and prescribing suitable treatment. However, no method has been established which objective measures can be used to evaluate severity symptoms. We for measuring thymus...
<b><i>Background:</i></b> Atopic dermatitis (AD) is an inflammatory skin disease characterized by both acute and chronic eczema. Various markers are used to clinically evaluate the severity of AD. In order identify a marker local AD, we measured IL-8, IL-18, vascular endothelial growth factor (VEGF), transforming factor-α (TGF-α) levels in stratum corneum (scIL-8, scIL-18, scVEGF scTGF-α) evaluated correlation between these cytokines clinical scores localized lesions....
In 2016, division of the genus Propionibacterium into four distinct genera was proposed. As a consequence, species acnes transferred to Cutibacterium gen. nov. as comb. The three recently proposed subspecies P. were not, however, accommodated in this proposal. Following very recent validation new combination for C. acnessubsp.defendens and an automatically created acnessubsp.acnes, we now propose combination, acnessubsp. elongatum type strain subsp. is JCM 18919T (=NCTC 13655T). On basis...
Background Wheat protein derivatives are used in a variety of products worldwide. Gluten is commercially ‘as is' or with modifications such as hydrolysis, which carried out to overcome its insolubility. Several cases contact urticaria following exposure hydrolysed wheat (HWP) cosmetics anaphylaxis caused by deamidated gluten food non‐food have been described. Objectives To evaluate the types HWP that higher allergenicity for percutaneous sensitization. Methods We enrolled 7 patients...
An anaerobic and aerotolerant bacterium, strain M12 T , was isolated from the meibum of inflamed human meibomian glands. Cells Gram-stain-positive, non-spore-forming non-motile rods. Growth on trypticase soy agar plates supplemented with 5 % sheep blood fastest at 30–37 °C under conditions. The 16S rRNA gene sequence revealed that it belongs to genus Cutibacterium a 98.0 similarity value closest species, acnes . Genome analysis type strains other species resulted in digital DNA–DNA...
<i>Background:</i> Atopic dermatitis (AD) is an inflammatory skin disease, characterized by existence of both acute and chronic eczema. Various markers are used to clinically evaluate the severity AD as a whole. However, little known regarding that can efficiently indicate localized lesion. Vascular endothelial growth factor (VEGF), potent activator vascular permeability, be increased in lesions. In order establish whether VEGF content stratum corneum (scVEGF) marker lesions, we...
Abstract Background To overcome the problem of maldistribution dermatologists in rural areas, live interactive teleconsultation systems are being used some countries. However, these not common use because few evaluations on their efficiency and economic viability were reported. Methods We constructed an easy‐to‐use asymmetric digital subscriber line (ADSL)‐based system conducted 150 trial sessions between two hospitals Shimane University Hospital. The clinical usefulness advantages this...
Propionibacterium acnes is one of the dominant commensals on human skin and also an opportunistic pathogen in relation to acne, sarcoidosis, prostate cancer, various infections. Recent investigations using housekeeping virulence genes have revealed that species consists three major evolutionary clades (types I, II, III). In order investigate protein expression differences between these phylogroups, proteomic profiles 21 strains P. were investigated. The proteins extracted from cells cultured...
Propionibacterium acnes, a commensal of human skin, is also an opportunistic pathogen common acne and certain infectious diseases. However, it still not obvious which strain pathogenic for disease, investigations to characterize strains using molecular typing methods such as MLST several housekeeping genes have been undertaken. date, analysis has focused mainly on isolated from Europeans, unclear whether the clonal distribution in other parts world similar. Here, we analysed 50 P. acnes...
A moderately thermophilic and heterotrophic bacterial strain, LAT, was isolated from microbial mats sampled at a hot spring in Nakabusa, Nagano, Japan. The cells of strain LAT were aerobic, Gram-stain-negative, non-sporulating, non-motile rod-shaped (2.0-4.1 µm long). formation dense cell aggregates liquid medium unique characteristic the strain. Strain grew optimally 50°C pH 7.5. Phylogenetic analysis based on 16S rRNA gene sequence revealed that nearest neighbour Schleiferia thermophila...
Actinic lichen planus (ALP) is a rare variant of in which develops on the light-exposed areas skin. ALP reported to occur African, Middle Eastern,and Indian populations, with very few cases Caucasians. Here, we report case Japanese man; best our knowledge, this first occurrence East Asian population. A 52-year-old man developed recurrent painful annular erythema face and hands. Histopathological examination his skin biopsy revealed lichenoid-type infiltrates lymphocytes histiocytes. We...
A 43-year-old Japanese man presented with reddish nodules on the ankle. The had a yellowish crust and eroded surface. Dermoscopy revealed red to milky-red globules at periphery some glomerular vessels in center whitish-pink network, which corresponded capillary dilatation papillary dermis prominent acanthosis, respectively. These structures were surrounded by peripheral structureless area multiple white, small, round center, corresponding macerated horny layer keratin plugs. Blood samples...
Cutibacterium modestum is a new species coined in 2020 as the fifth of genus Cutibacterium, which includes acnes. The predicted minor but common member skin microbiome and group tentatively named "Propionibacterium humerusii". description has been provided only with single strain. To establish characteristics C. search for possible disease-related subtypes, we investigated biochemical eight live strains performed silico comparison nine genomes. features, included morphology Gram-stain...