A5051015383- Dermatology and Skin Diseases
- Skin Protection and Aging
- Allergic Rhinitis and Sensitization
- Acne and Rosacea Treatments and Effects
- Contact Dermatitis and Allergies
- melanin and skin pigmentation
- Dermatologic Treatments and Research
- Asthma and respiratory diseases
- Cutaneous lymphoproliferative disorders research
- Nail Diseases and Treatments
- Systemic Sclerosis and Related Diseases
- Vascular Tumors and Angiosarcomas
- Olfactory and Sensory Function Studies
- Oral Health Pathology and Treatment
- Celiac Disease Research and Management
- Immune Cell Function and Interaction
- Colorectal Cancer Treatments and Studies
- Multiple Myeloma Research and Treatments
- IL-33, ST2, and ILC Pathways
- HER2/EGFR in Cancer Research
- Photodynamic Therapy Research Studies
- vaccines and immunoinformatics approaches
- Dermatological diseases and infestations
- Seaweed-derived Bioactive Compounds
- Hair Growth and Disorders
Wakayama Medical University
2012-2021
Daiwa Pharmaceutical Co. (Japan)
2004-2020
In-Q-Tel
2016
Wakayama University
2016
Kobe Tokiwa University
2010
Tokiwa University
2010
National Oilwell Varco (United States)
2004
Japan Chemical Innovation and Inspection Institute
1990
Chemicals Evaluation and Research Institute
1990
Summary Thymic stromal lymphopoietin (TSLP) is known for its capacity to induce CD11c+ myeloid dendritic cells promote T helper type 2 (Th2)-skewed inflammatory responses. Although increased expression of TSLP was reported in the lesional skin limited numbers patients with atopic dermatitis (AD), relationships between degree and severity AD, epidermal barrier function eruption remain be elucidated. The aim this study examine using a non-invasive method sizeable group patients. Stratum...
Photodamaged skin exhibits wrinkles, pigmented spots, dryness and tumors. Solar UV radiation induces cyclobutane pyrimidine dimers (CPD) further produces base oxidation by reactive oxygen species (ROS). ROS are thought to be a major factor initiate the up-regulation of matrix metalloproteinases (MMPs) in keratinocytes fibroblasts via activation receptor proteins on cell membrane fibroblasts, degrade fiber components dermis, leading wrinkle formation. Coenzyme Q10 (CoQ10) was reported reduce...
To cite this article: Morita E, Takahashi H, Niihara Dekio I, Sumikawa Y, Murakami Matsunaka H. Stratum corneum TARC level is a new indicator of lesional skin inflammation in atopic dermatitis. Allergy 2010; 65 : 1166–1172. Abstract Background: Management dermatitis (AD) requires judging the symptoms local lesions and prescribing suitable treatment. However, no method has been established which objective measures can be used to evaluate severity symptoms. We for measuring thymus...
Glycolic acid (GA) peels are frequently performed as adjuvants to the treatment of facial acne. There have been few clinical trials reported GA for acne in people with darker skin.To determine safety and efficacy moderate vulgaris Asian skin.In this prospective, randomized, double-blind, placebo-controlled, split-face trial, 26 patients were treated 40% (pH 2.0) on half face placebo other half. The procedure was five times at 2-week intervals.The sides had statistically significant...
To identify and characterize undescribed systemic sclerosis (SSc)-specific autoantibodies targeting nucleolar antigens to assess their clinical significance.
This study presents "aUToAntiBody Comprehensive Database (UT-ABCD)", a comprehensive catalog of autoantibody profiles in 284 human individuals. The subjects include patients diagnosed with Coronavirus disease 2019 (COVID-19; n = 73), systemic sclerosis (SSc; 32), lupus erythematosus (SLE; 60), anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV; 29), atopic dermatitis (AD; 26), as well healthy controls (HC; 64). Our investigation employs proteome-wide screening (PWAbS) that...
Abstract Few clinical studies have examined the utility of bipolar fractional radiofrequency ( FRF ) therapy as a treatment for atrophic acne scars and active in people with darker skin. This study was designed to compare safety efficacy vulgaris. Twenty‐three Japanese patients mild severe on both cheeks were treated system (eMatrix; Syneron, Yokneam Illit, Israel). Five sessions carried out at 1‐month intervals, followed up 3 months after final treatment. Assessments scar severity number...
Abstract Chemical peeling is one of the dermatological treatments available for certain cutaneous diseases and conditions or improvement cosmetic appearance photo‐aged skin. We assessed photo‐chemopreventive effect several clinically used chemical agents on ultraviolet‐irradiated skin hairless mice. was done using 35% glycolic acid dissolved in distilled water, 30% salicylic ethanol, 10% trichloroacetic water at right back mice every 2 weeks acid, 4 a total 18 after establishment by...
The CXCR4/CXCL12 pathway has recently been reported to be involved in stimulating the metastasis of many different neoplasms, which CXCR4 activates various phenomena such as chemotaxis, invasion, angiogenesis and proliferation. purpose this study was analyze a possible association between expression chemokine receptors CXCR4, CCR6 CCR7 with clinicopathological features cutaneous malignant melanoma, assess usefulness these for diagnosis prognosis. In our study, percentage immunoexpression...
Cosmetic moisturisers were applied to one side of the face 18 male Japanese patients with acne vulgaris who treated a topical administration adapalene and clindamycin phosphate gels. We assessed alleviating effect on effects treatment. The severity number inflammatory non-inflammatory lesions measured at 0, 2, 4 weeks. water content in stratum corneum transepidermal loss by comparing moisturiser-treated untreated sides face. sensation skin dryness irritation both subjects. observed that use...
The efficacy of combined therapy with a retinoid and antibiotic for Japanese patients acne vulgaris remains to be established. Further, maintenance strategies limiting the use topical retinoids must identified. objectives this study are determine sequential application adapalene clindamycin phosphate assess impact regimen on patients' quality life. Sixty-six were recruited. comprised two phases. For 4-week initial treatment, 1% gel was applied twice daily 0.1% gel, once. In phase, randomly...
It is unclear whether hair washing effective against scalp eruption and pruritus caused by seborrheic dermatitis or psoriasis vulgaris.To assess a proper hair-washing regimen, including the use of antibacterial shampoo, can ameliorate symptoms alter composition microflora.Eighteen patients with vulgaris eruptions were instructed in techniques daily washing, rinsing, shampooing, which they underwent for 12 weeks. They used control shampoo weeks 1-4 9-12, an during 5-8. At start test period at...
Abstract A series of natural rubber vulcanizates containing varied amounts sulfur and an accelerator (N‐cyclohexyl‐2‐benzothiazyl sulfenamide, CBS) were prepared their resistance to attack by a strain Nocardia , capable utilizing as carbon substrate, was examined. The higher the content or CBS, less weight loss after microbial attack. In this system curing without filler, rate degradation suggested depend on cross‐link density estimated from swelling. Addition calcium carbonate filler did...
Skin melanin content is an important indicator for ascertaining the pathology of skin pigmentation diseases, but its analysis necessitates a biopsy or other means collecting tissue, posing considerable burden to patient, and making it difficult observe how given site changes over time. Here, we aimed establish non-invasive method quantifying eumelanin pheomelanin stratum corneum.Sun-exposed non-exposed samples from 10 healthy Japanese subjects were compared. We harvested outermost layer...
Loss-of-function mutations of filaggrin (FLG) gene are the strongest known genetic risk factor for atopic dermatitis (AD). It is still debatable how FLG and resulting abnormal amount protein contribute to skin barrier function symptoms AD. In this study, we examined effects loss-of-function on severity lesions in 55 patients with AD by evaluating eight 47 without mutations. The results showed that mutation did not affect duration AD, degree local inflammatory symptoms, water content...
Although an inflammatory response upon acute injury caused by ultraviolet radiation (UV) can be observed immediately, the influence of long-term, repetitive low-dose UV exposure on skin cannot precisely perceived, making early detection chronic damage difficult. This study investigated bioactive substances in stratum corneum as a potential and sensitive indicator sun using receiver operating characteristic (ROC) analysis.Receiver analysis was performed to assess responsiveness cytokines...
To verify the usefulness of moisturizers, a multi-center study was conducted on patients with atopic dermatitis who visited 3 university hospitals in Japan between November 2009 and March 2012. Thirty-seven dry skin stable symptoms were receiving topical oral treatments given moisturizers for 8 weeks. The contained components such as glycerin seawater minerals forms: lotion, emulsion, cream. chosen by physicians based degree dryness patients’ skin. In addition to observing condition entire...
Clinical studies have clarified the usefulness of moisturizers for dry skin diseases. However, few reports exist on appropriate application with respect to physiological functions.To clarify optimal moisturizer method basis functions.This study investigated time, dose, and frequency from perspective physiology. In healthy subjects, stratum corneum water content (SCW) was compared between different times (immediately [≤5 min] 90 min after bathing), doses (0.5, 1.0, 2.0 mg/cm2 ), frequencies...