A5038183034- Adipose Tissue and Metabolism
- Parkinson's Disease Mechanisms and Treatments
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Neurological disorders and treatments
- Cardiovascular Disease and Adiposity
- Botulinum Toxin and Related Neurological Disorders
- Asthma and respiratory diseases
- Ion channel regulation and function
- Telomeres, Telomerase, and Senescence
- Hepatocellular Carcinoma Treatment and Prognosis
- Viral Infections and Immunology Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Fibrosis and Remodeling
- Eosinophilic Esophagitis
- Systemic Lupus Erythematosus Research
- Cancer Mechanisms and Therapy
- Elevator Systems and Control
- Hepatitis B Virus Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiac pacing and defibrillation studies
- Allergic Rhinitis and Sensitization
- Vascular Malformations and Hemangiomas
Hiroshima University Hospital
2025
The University of Tokyo
2023-2025
Citizen (Japan)
2019-2025
Niigata City General Hospital
2022-2024
Jichi Medical University
2014-2024
Jichi Medical University Saitama Medical Center
2024
National Center For Child Health and Development
2022-2024
University of Toyama
2001-2024
Yokohama National University
2024
Fukuoka University
2018-2023
Recently, we and others reported that early repolarization (J wave) is associated with idiopathic ventricular fibrillation. However, its clinical genetic characteristics are unclear.This study included 50 patients (44 men; age, 45 ± 17 years) fibrillation repolarization, 250 age- sex-matched healthy controls. All of the had experienced arrhythmia events, 8 (16%) a family history sudden death. Ventricular was inducible by programmed electric stimulation in 15 29 (52%). The heart rate slower...
Epidemiological studies demonstrated that cleaning work and frequent use of products are risk factors for asthma. Laundry detergents have been reported to epithelial barrier-opening effects. However, whether laundry directly induce airway inflammation its mechanisms in vivo remain be elucidated.Two commercial two commonly used surfactants cosmetics (sodium lauryl sulfate sodium dodecyl benzene sulfonate) were intranasally administered mice. Lungs analyzed using flow cytometry, histology,...
Endothelial cells have an important role in maintaining vascular homeostasis. Age-related disorders (including obesity, diabetes, and hypertension) or aging per se induce endothelial dysfunction that predisposes to the development of atherosclerosis. Polyphenols been reported suppress age-related cell disorders, but their function is yet be determined. We investigated influence boysenberry polyphenol on health under metabolic stress a murine model dietary obesity. found administration...
The aim of this study was to investigate the relationship between J-wave dynamics and arrhythmias during myocardial ischaemia in patients with vasospastic angina (VSA).Sixty-seven consecutive diagnosed VSA by a provocation test for coronary spasm were grouped according whether they had J wave baseline electrocardiograms or not (VSA-JW group, n = 14; VSA-non-JW group: 53). We retrospectively studied associations ST-segment induced ventricular fibrillations (VFs) spasm. In VSA-JW 7 14 showed...
Highlights•GABA and GABA-BR1 are increased in brown adipose tissue (BAT) obesity•GABA signaling promotes BAT mitochondrial dysfunction obese mice•GABA-BR1 inhibition ameliorates re-browning•Inhibition of GABA calcium overload restore functionSummaryBrown is a metabolically active organ that contributes to the maintenance systemic metabolism. The sympathetic nervous system plays important roles homeostasis its browning activation. However, role other neurotransmitters remains largely unknown....
Abstract Patients with type 2 diabetes treated Sodium glucose transporter (SGLT2) inhibitors show reduced mortality and hospitalization for heart failure (HF). SGLT2 are considered to activate multiple cardioprotective pathways; however, underlying mechanisms not fully described. This study aimed elucidate the of beneficial effects on failing heart. We generated a left ventricular (LV) pressure overload model in C57BL/6NCrSlc mice by transverse aortic constriction (TAC) examined...
Fabry disease (FD) is an inherited lysosomal storage caused by deficiency of α-galactosidase A (α-Gal A), enzyme that hydrolyzes glycosphingolipids in lysosome. Accumulation glycosphingolipids, mainly globotriaosylceramide (Gb3) tissues, induces cellular dysfunction leading to multi-organ disorder. Gene therapy a promising strategy can overcome these problems, and virus vectors such as adeno-associated (AAV) have been used for study on gene therapy. We human Gb3 synthetase-transgenic...
Pulmonary arterial hypertension (PAH) is characterized by remodeling and narrowing of the pulmonary arteries, which lead to elevation right ventricular pressure, heart failure, death. Proliferation artery smooth muscle cells (PASMCs) thought be central pathogenesis PAH, although underlying mechanisms are still being explored. The protein p53 involved in cell cycle coordination, DNA repair, apoptosis, cellular senescence, but its role (PH) not fully known. We developed a mouse model...
IntroductionParkinson's disease (PD) is characterized by a range of classic motor symptoms and heterogeneous nonmotor that affect patients' quality life (QoL). Studies have individually reported the effect either or on QoL; however, thorough assessment greatest influence QoL limited. This JAQPAD study examined both patient demographics in large population patients with PD Japan.MethodsAll members Japan Parkinson's Disease Association were invited to participate study. Questionnaires...
Background and aim: During endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNB), Franseen needles can help collect sufficient tissue to permit histopathological assessment. However, its efficacy might be limited by the size of targeted lesion. This study aimed evaluate feasibility assessment small solid pancreatic lesions using a 22-gauge during EUS-FNB. Methods: retrospective evaluated data from all patients who underwent EUS-FNB for at University Toyama Hospital between...
Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) enables easy and accurate pathological assessment. Here, we compared assessed the area of samples on glass slides for three needle types: a 19-gauge Franseen (Acquire, Boston Scientific, Natick, MA, USA), 22-gauge needle, aspiration (FNA) (EZ Shot 3 Plus; Olympus, Tokyo, Japan). Among patients with suspected pancreatic cancer, ≥20 mm tumor located in body tail, who underwent EUS-FNA or FNB between June 2018 March 2020, 10 were...