A5056446724- melanin and skin pigmentation
- RNA regulation and disease
- Biochemical Analysis and Sensing Techniques
- Skin Protection and Aging
- Olfactory and Sensory Function Studies
- Mast cells and histamine
- Cell Adhesion Molecules Research
- RNA and protein synthesis mechanisms
- Autoimmune Bullous Skin Diseases
- Atherosclerosis and Cardiovascular Diseases
- Genetic and rare skin diseases.
- RNA Research and Splicing
- Acne and Rosacea Treatments and Effects
- Cancer and Skin Lesions
- Dermatological and Skeletal Disorders
- Skin and Cellular Biology Research
- Autoimmune and Inflammatory Disorders
- Cutaneous Melanoma Detection and Management
- Herpesvirus Infections and Treatments
- Hair Growth and Disorders
- Garlic and Onion Studies
- Glycosylation and Glycoproteins Research
- T-cell and B-cell Immunology
- Retinal Development and Disorders
- Nail Diseases and Treatments
Yamagata University
2016-2025
Yamagata University Hospital
2021-2023
John Wiley & Sons (United States)
2023
Liechtenstein Institute
2023
Oxfam
2023
Hudson Institute
2023
John Wiley & Sons (United Kingdom)
2023
Iwate Prefectural Central Hospital
2014
Nagoya University
1973-2013
Morinaga Institute of Biological Science
2013
During the 2011 International Pigment Cell Conference (IPCC), Vitiligo European Taskforce (VETF) convened a consensus conference on issues of global importance for vitiligo clinical research. As suggested by an international panel experts, focused four topics: classification and nomenclature; definition stable disease; Koebner's phenomenon (KP); 'autoimmune vitiligo'. These topics were discussed in seven working groups representing different geographical regions. A emerged that segmental be...
The treatment of vitiligo can be challenging. Up-to-date agreed consensus recommendations on the use topical and systemic therapies to facilitate clinical management are currently lacking.To develop internationally agreed-upon expert-based for vitiligo.In this statement, a consortium 42 international experts four patient representatives participated in different online live meetings strategy vitiligo. At least two summarized evidence topics included algorithms. A survey was then given core...
The treatment of vitiligo can be challenging and depends on several factors such as the subtype, disease activity, extent, goals. Vitiligo usually requires a long-term approach. To improve management worldwide, clear up-to-date guide based international consensus with uniform stepwise recommendations is needed.To reach an nomenclature to develop algorithm for diagnosis, assessment, vitiligo.In this statement, consortium 42 experts four patient representatives participated in online live...
The effect of passion fruit, the fruit Passiflora edulis, on melanin inhibition and collagen synthesis was studied using cultured human melanoma fibroblast cells. Passion divided into three parts, rind (PF-R), pulp (PF-P), seed (PF-S), each part extracted 80% ethanol. concentration polyphenols higher in PF-S than PF-R or PF-P. Treatment cells with led to melanogenesis. In addition, production total soluble elevated dermal presence PF-S. PF-P did not yield these effects. Furthermore, removal...
The whole-genome sequence of carnation (Dianthus caryophyllus L.) cv. 'Francesco' was determined using a combination different new-generation multiplex sequencing platforms. total length the non-redundant sequences 568,887,315 bp, consisting 45,088 scaffolds, which covered 91% 622 Mb genome estimated by k-mer analysis. N50 values contigs and scaffolds were 16,644 bp 60,737 respectively, longest scaffold 1,287,144 bp. average GC content contig 36%. A 1050, 13, 92 143 genes for tRNAs, rRNAs,...
Summary Rhododendrol, an inhibitor of melanin synthesis developed for lightening/whitening cosmetics, was recently reported to induce a depigmentary disorder principally at the sites repeated chemical contact. Rhododendrol competitively inhibited mushroom tyrosinase and served as good substrate, while it also showed cytotoxicity against cultured human melanocytes high concentrations sufficient inhibiting tyrosinase. The abolished by phenylthiourea, chelator copper ions active site, specific...
Pigment Cell & Melanoma ResearchVolume 28, Issue 3 p. 363-369 Meeting Report Developing core outcome set for vitiligo clinical trials: international e-Delphi consensus Viktoria Eleftheriadou, Corresponding Author Eleftheriadou Centre of Evidence Based Dermatology, University Nottingham, UKCORRESPONDENCE Khaled Ezzedine and e-mails: khaled.ezzedine@chu-bordeaux.fr; viktoria.eleftheriadou@nottingham.ac.ukSearch more papers by this authorKim Thomas, Kim Thomas UKSearch authorNanja van Geel,...
Generalized vitiligo is an acquired disorder in which depigmented macules result from the autoimmune loss of melanocytes involved regions skin. frequently associated with other diseases, particularly thyroid diseases (Hashimoto's thyroiditis and Graves' disease), rheumatoid arthritis, adult-onset type 1 diabetes mellitus, psoriasis, pernicious anemia, systemic lupus erythematosus, Addison's disease. One hundred thirty-three Japanese patients generalized were enrolled this study to...
Human metapneumovirus (HMPV) has been a notable etiological agent of acute respiratory infection in humans, but it was not discovered until 2001, because HMPV replicates only limited number cell lines and the cytopathic effect (CPE) is often mild. To promote study HMPV, several groups have generated green fluorescent protein (GFP)-expressing recombinant strains (HMPVGFP). However, growing evidence complicated understanding line specificity seems to vary notably among strains. In addition,...
Vitiligo is an autoimmune disease involving melanocyte-targeting T cells initiated by environmental and genetic factors. Steroids tacrolimus have been used as topical treatments. Recently, novel agents targeting Janus kinase (JAK), a family of tyrosine kinases that regulates cytokine signaling, emerged. Ruxolitinib the first approved in vitiligo therapy. Furthermore, ritlecitinib currently under clinical trials for oral treatment active vitiligo. In this review, we discuss possibility JAK...
In the mouse, more than 16 loci are associated with mutant phenotypes that include defective pigmentation, aberrant targeting of lysosomal enzymes, prolonged bleeding, and immunodeficiency, result biogenesis cytoplasmic organelles: melanosomes, lysosomes, various storage granules. Many these mouse mutants homologous to human Hermansky–Pudlak syndrome (HPS), Chediak–Higashi syndrome, Griscelli syndrome. We have mapped positionally cloned one loci, buff ( bf ), which has a phenotype similar...
Hermansky-Pudlak syndrome (HPS) is a genetic disease of lysosome, melanosome, and granule biogenesis. Mutations six different loci have been associated with HPS in humans, the most frequent which are mutations HPS1 HPS4 genes. Here, we show that proteins components two novel protein complexes involved biogenesis melanosome lysosome-related organelles: organelles complex-(BLOC) 3 BLOC-4. The phenotypes Hps1-mutant (pale-ear; ep) Hps4-mutant (light-ear; le) mice humans very similar, cells from...
// Nguyen Dinh Thang 1, 2 , Ichiro Yajima 3 Mayuko Y. Kumasaka Machiko Iida Tamio Suzuki 4 Masashi Kato 1 Unit of Environmental Health Sciences, Department Biomedical College Life and Chubu University, Kasugai-shi, Aichi, Japan Biochemistry Plant Physiology, VNU University Science, Vietnam National Hanoi, Occupational Health, Nagoya Graduate School Medicine, Nagoya, Dermatology, Yamagata Faculty Yamagata, Correspondence to: Kato, e-mail: katomasa@med.nagoya-u.ac.jp Keywords: Deltex-3-like,...
Abstract Because some users develop depigmentation after the use of melanogenesis‐inhibiting products containing quasi‐drug ingredient Rhododenol, Japanese Dermatological Association (JDA) established a Special Committee on Safety Cosmetics Containing Rhododenol July 17, 2013 and management guide for dermatologists has been updated website in order to delineate diagnostic criteria Rhododenol‐induced leukoderma provides broad standard treatment based current knowledge. This is produced basis...