A5061054620- Cell Image Analysis Techniques
- Melanoma and MAPK Pathways
- melanin and skin pigmentation
- Hearing, Cochlea, Tinnitus, Genetics
- Skin Protection and Aging
- Computational Drug Discovery Methods
- bioluminescence and chemiluminescence research
- Vestibular and auditory disorders
- Noise Effects and Management
- Hair Growth and Disorders
- Plasma Applications and Diagnostics
- Cutaneous Melanoma Detection and Management
- Peptidase Inhibition and Analysis
- Heavy Metal Exposure and Toxicity
- Skin and Cellular Biology Research
- Arsenic contamination and mitigation
- Mast cells and histamine
- Acne and Rosacea Treatments and Effects
- Dermatologic Treatments and Research
- Cancer Cells and Metastasis
- Pediatric health and respiratory diseases
- Medical Research and Treatments
- Protease and Inhibitor Mechanisms
- Cellular Mechanics and Interactions
- Congenital gastrointestinal and neural anomalies
Nagoya University
2011-2024
Chubu University
2011-2024
Aichi Developmental Disability Center
2024
Environmental Health
2023
Aichi Human Service Center
2018-2019
VNU University of Science
2015
Kagoshima University
2015
The University of Tokyo
2015
Society of Environmental Toxicology and Chemistry
2015
Kitasato University
2015
Cutaneous malignant melanoma is one of the most serious skin cancers and highly invasive markedly resistant to conventional therapy. Melanomagenesis initially triggered by environmental agents including ultraviolet (UV), which induces genetic/epigenetic alterations in chromosomes melanocytes. In human melanomas, RAS/RAF/MEK/ERK (MAPK) PI3K/PTEN/AKT (AKT) signaling pathways are two major constitutively activated through genetic alterations. Mutations RAF, RAS, PTEN contribute antiapoptosis,...
Alkaline phosphatase (ALP) activity was detected in the restricted mesenchymal and epithelial regions mouse vibrissal follicles. Its localization strength dramatically changed during hair cycle. Activity dermal papilla (DP) moderate very early anagen, reached a maximal level decreased at proximal region of DP after mid kept low catagen. The bulbar sheath showed intense ALP only anagen. Although most epithelium did not show activity, germinative epidermal cells that were adjacent to...
Various environmental and genetic factors affect the development progression of skin cancers including melanoma. Melanoma is initially triggered by ultraviolet (UV) light, then genetic/epigenetic alterations occur in melanocytes. These first triggers alter conditions numerous genes proteins, they induce and/or reduce gene expression activate repress protein stability activity, resulting melanoma progression. Microphthalmia-associated transcription factor ( MITF ) a master regulator...
We are routinely exposed to low frequency noise (LFN; below 0.5 kHz) at moderate levels of 60–70 dB sound pressure level (SPL) generated from various sources in occupational and daily environments. LFN has been reported affect balance humans. However, there is limited information about the influence chronic exposure for balance. In this study, we investigated whether a 70 SPL affects vestibule, which one organs responsible mice. Wild-type ICR mice were 1 month (0.1 high (HFN; 16 distance...
// Nguyen Dinh Thang 1, 2 , Ichiro Yajima 3 Mayuko Y. Kumasaka Machiko Iida Tamio Suzuki 4 Masashi Kato 1 Unit of Environmental Health Sciences, Department Biomedical College Life and Chubu University, Kasugai-shi, Aichi, Japan Biochemistry Plant Physiology, VNU University Science, Vietnam National Hanoi, Occupational Health, Nagoya Graduate School Medicine, Nagoya, Dermatology, Yamagata Faculty Yamagata, Correspondence to: Kato, e-mail: katomasa@med.nagoya-u.ac.jp Keywords: Deltex-3-like,...
Sewage and treated water can be a heat source in urban area due to large capacity, thus recovery reuse of its energy is one the most desirable plans for sewerage system. In this paper, characteristics wastewater, plans, some experiences Japan are presented. Full-scale projects heating cooling Tokyo Metropolitan Districts project melting snow Sapporo City discussed. The key factors found experience were setting pumps near demand points technical developments equipment prevent system from...
Malignant melanoma is one of the most aggressive cancers and its incidence worldwide has been increasing at a greater rate than that any other cancer. We previously reported constitutively activated RFP-RET-carrying transgenic mice (RET-mice) spontaneously develop malignant melanoma. In this study, we showed expression levels intrinsic c-Ret, glial cell line-derived neurotrophic factor (Gdnf) Gdnf receptor alpha 1 (Gfra1) transcripts in melanomas from RET-transgenic were significantly...
Abstract Nevus-associated melanomas arise from pre-existing benign lesions, but de novo can also develop in the absence of such lesions. Few studies have addressed latter phenomenon because no animal models been described which clearly a manner. In this study, we address need defining RFP-RET-transgenic mice (RET mice) as mouse model for multi-step melanomagenesis that proceeds via tumor-free, benign, premalignant, and malignant stages. Melanomas RET exhibited decreased expression levels...
Abstract Background: Previous experimental studies showed that single ultraviolet B (UVB) light irradiation increased levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a well-established biomarker carcinogenesis and oxidative DNA damage, in epithelial cells animals humans. We conducted for the first time an epidemiologic study to investigate correlations among skin pigmentation, sunlight exposure human daily life. Methods: Digitalized pigmentation creatinine-adjusted urinary 8-OHdG were...
Abstract Despite the fact that manganese (Mn) is known to be a neurotoxic element relevant age-related disorders, risk of oral exposure Mn for hearing loss remains unclear. In this study, we orally exposed wild-type young adult mice (Mn-exposed WT-mice) at 1.65 and 16.50 mg/L 4 weeks. Mn-exposed WT-mice showed acceleration loss. had neurodegeneration spiral ganglion neurons (SGNs) with increased number lipofuscin granules. also hypoxia-inducible factor-1 alpha (Hif-1α) protein less...
Skin cancer is one of the most common cancers. Melanoma accounts for less than 2% skin cases but causes a large majority deaths. Early detection malignant melanoma remains key factor in saving lives. However, diagnosis still clinically challenging. Here, we developed confocal photothermal microscope noninvasive, label-free, three-dimensional imaging melanoma. The axial resolution ~3 times higher that commonly used microscope. Three-dimensional microscopic distribution melanin pigmented...
There is no information on the association between oral exposure to arsenic (As) and hearing loss in humans or mice. In this combined epidemiological study experimental study, of As with people aged 12-29 years young mice was examined. Subjects group (n = 48), who were drinking tube well water contaminated As, showed significantly higher risks at 4 kHz [odds ratio (OR) 7.60; 95% confidence interval (CI): 1.56, 57.88], 8 (OR 5.00; CI: 1.48, 18.90) 12 8.72; 2.09, 47.77) than did subjects...
Arsenic (As) pollution in drinking water is a worldwide health risk for humans. We previously showed hearing loss young people who live areas of As-polluted and mice orally treated with As. In this study, we epidemiologically examined associations between As levels toenails 145 Bangladeshi aged 12–55 years 2014. Levels toenails, but not those urine, were shown to be significantly correlated at 4 kHz [odds ratio (OR) = 4.27; 95% confidence interval (CI): 1.51, 12.05], 8 (OR 3.91; CI: 1.47,...
Adult Cebpb KO mice incisors present amelogenin-positive epithelium pearls, enamel and dentin allopathic hyperplasia, fewer Sox2-positive cells in labial cervical loop epitheliums, reduced Sox2 expression epithelial stem cells. Thus, acts upstream of to regulate stemness. In this study, demonstrated cementum-like hard tissue dental pulp, loss polarity by ameloblasts, matrix ameloblastic layer, increased epithelial-mesenchymal transition (EMT) markers a knockdown mouse cell line. Runx2 the...