A5072269058- melanin and skin pigmentation
- Melanoma and MAPK Pathways
- Heavy Metal Exposure and Toxicity
- Arsenic contamination and mitigation
- Hearing, Cochlea, Tinnitus, Genetics
- Biochemical Analysis and Sensing Techniques
- Cell Adhesion Molecules Research
- Computational Drug Discovery Methods
- Skin Protection and Aging
- Cell Image Analysis Techniques
- Noise Effects and Management
- Retinal Development and Disorders
- bioluminescence and chemiluminescence research
- Heavy metals in environment
- Retinoids in leukemia and cellular processes
- RNA regulation and disease
- Ubiquitin and proteasome pathways
- Hair Growth and Disorders
- Cutaneous Melanoma Detection and Management
- Cancer Cells and Metastasis
- Acne and Rosacea Treatments and Effects
- Vestibular and auditory disorders
- Plasma Applications and Diagnostics
- Glycosylation and Glycoproteins Research
- Fluoride Effects and Removal
Shibaura Institute of Technology
2022-2025
Nagoya University
2015-2024
Chubu University
2012-2024
Environmental Health
2023
Institut Curie
2006-2021
La Ligue Contre le Cancer
2020-2021
Université Paris-Saclay
2020-2021
Centre National de la Recherche Scientifique
2006-2021
Inserm
2013-2021
Université Paris Sciences et Lettres
2020-2021
Cutaneous malignant melanoma is one of the most serious skin cancers and highly invasive markedly resistant to conventional therapy. Melanomagenesis initially triggered by environmental agents including ultraviolet (UV), which induces genetic/epigenetic alterations in chromosomes melanocytes. In human melanomas, RAS/RAF/MEK/ERK (MAPK) PI3K/PTEN/AKT (AKT) signaling pathways are two major constitutively activated through genetic alterations. Mutations RAF, RAS, PTEN contribute antiapoptosis,...
Waardenburg syndrome type 2 (WS2) is an autosomal dominant disorder characterized by a combination of pigmentary and auditory abnormalities. Approximately 20% WS2 cases are associated with mutations in the gene encoding microphthalmia-associated transcription factor (MITF). MITF plays critical role development both neural-crest-derived melanocytes optic cup-derived retinal pigmented epithelium (RPE); loss functional Mitf mice results complete absence all pigment cells, which turn induces...
Summary Melanocytes are mainly found in the skin and more rarely other parts of body, including heart. We analyzed localization heart melanocytes their levels pigmentation a series mutant mice presenting different numbers skin. that were localized valves (mitral, tricuspid, aortic) septa (ventricular atrial). Moreover, appears to reflect Mice having high or low level pigmented cells and/or melanin have similar lifespan. In this respect, probably not essential healthy non‐stressful environment.
Various environmental and genetic factors affect the development progression of skin cancers including melanoma. Melanoma is initially triggered by ultraviolet (UV) light, then genetic/epigenetic alterations occur in melanocytes. These first triggers alter conditions numerous genes proteins, they induce and/or reduce gene expression activate repress protein stability activity, resulting melanoma progression. Microphthalmia-associated transcription factor ( MITF ) a master regulator...
We are routinely exposed to low frequency noise (LFN; below 0.5 kHz) at moderate levels of 60–70 dB sound pressure level (SPL) generated from various sources in occupational and daily environments. LFN has been reported affect balance humans. However, there is limited information about the influence chronic exposure for balance. In this study, we investigated whether a 70 SPL affects vestibule, which one organs responsible mice. Wild-type ICR mice were 1 month (0.1 high (HFN; 16 distance...
// Nguyen Dinh Thang 1, 2 , Ichiro Yajima 3 Mayuko Y. Kumasaka Machiko Iida Tamio Suzuki 4 Masashi Kato 1 Unit of Environmental Health Sciences, Department Biomedical College Life and Chubu University, Kasugai-shi, Aichi, Japan Biochemistry Plant Physiology, VNU University Science, Vietnam National Hanoi, Occupational Health, Nagoya Graduate School Medicine, Nagoya, Dermatology, Yamagata Faculty Yamagata, Correspondence to: Kato, e-mail: katomasa@med.nagoya-u.ac.jp Keywords: Deltex-3-like,...
Health risk for well drinking water is a worldwide problem. Our recent studies showed increased toxicity by exposure to barium alone (≤700 µg/L) and coexposure (137 arsenic (225 µg/L). The present edition of WHO health-based guidelines revised in 2011 has maintained the values (10 (700 µg/L), but not elements such as manganese, iron zinc. Nevertheless, there have been very few on human samples. This study significant correlations between levels barium, its homologous (magnesium, calcium...
Lung cancer is among the most prevalent and lethal malignancies worldwide, with non-small cell lung (NSCLC) accounting for majority of cases. Overactivation EGFR/AKT signaling pathway contributes significantly to NSCLC progression metastasis. Cisplatin, a widely used chemotherapeutic agent, faces limitations due severe side effects emergence resistant cells. Acyclic retinoid (ACR), synthetic derivative vitamin A, has shown antitumor in hepatocellular carcinoma, but its efficacy against...
Abstract The organ‐specific and temporal control of gene activation/inactivation is a key issue in the understanding protein function during normal pathological development oncogenesis. We generated transgenic mice bearing tamoxifen‐dependent Cre recombinase (Tyr::Cre‐ERT2) expressed under 6.1 kb murine tyrosinase promoter order to facilitate targeted spatiotemporally controlled somatic recombination melanoblasts/melanocytes. Cre‐ERT2 production was detected tissues containing melanocytes....
Malignant melanoma is one of the most aggressive cancers and its incidence worldwide has been increasing at a greater rate than that any other cancer. We previously reported constitutively activated RFP-RET-carrying transgenic mice (RET-mice) spontaneously develop malignant melanoma. In this study, we showed expression levels intrinsic c-Ret, glial cell line-derived neurotrophic factor (Gdnf) Gdnf receptor alpha 1 (Gfra1) transcripts in melanomas from RET-transgenic were significantly...
Abstract Nevus-associated melanomas arise from pre-existing benign lesions, but de novo can also develop in the absence of such lesions. Few studies have addressed latter phenomenon because no animal models been described which clearly a manner. In this study, we address need defining RFP-RET-transgenic mice (RET mice) as mouse model for multi-step melanomagenesis that proceeds via tumor-free, benign, premalignant, and malignant stages. Melanomas RET exhibited decreased expression levels...
Explosive increases in skin cancers have been reported more than 36 million patients with arsenicosis caused by drinking arsenic-polluted well water. This study and previous studies showed high levels of barium as arsenic the However, there no reports showing a correlation between cancer. In this study, we examined whether (BaCl2) may independently cancer-related effects on human precancerous keratinocytes (HaCaT). Barium (5–50 µM) biologically promoted anchorage-independent growth invasion...
Abstract Background: Previous experimental studies showed that single ultraviolet B (UVB) light irradiation increased levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a well-established biomarker carcinogenesis and oxidative DNA damage, in epithelial cells animals humans. We conducted for the first time an epidemiologic study to investigate correlations among skin pigmentation, sunlight exposure human daily life. Methods: Digitalized pigmentation creatinine-adjusted urinary 8-OHdG were...
The retinal pigment epithelium (RPE) shares its developmental origin with the neural retina (NR). When RPE development is disrupted, cells in presumptive region abnormally differentiate into NR-like cells. Therefore, prevention of NR differentiation area seems to be essential for regionalizing during eye development. However, molecular mechanisms are not fully understood. In this study, we conducted a functional inhibition transcription factor Otx2, which required development, using early...