A5036904729- Bone health and osteoporosis research
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Prenatal Screening and Diagnostics
- Estrogen and related hormone effects
- Microbial infections and disease research
- Renal and related cancers
- Bacteriophages and microbial interactions
- Pharmacological Effects of Natural Compounds
- Radiomics and Machine Learning in Medical Imaging
- Crystallization and Solubility Studies
- Sperm and Testicular Function
- Trace Elements in Health
- Escherichia coli research studies
- Uterine Myomas and Treatments
- Maternal and fetal healthcare
- Erythrocyte Function and Pathophysiology
- Sexual Differentiation and Disorders
- Mycotoxins in Agriculture and Food
- Synthesis and Characterization of Heterocyclic Compounds
- Chromium effects and bioremediation
- Genetic Syndromes and Imprinting
- X-ray Diffraction in Crystallography
- Pregnancy and preeclampsia studies
- Peripheral Artery Disease Management
Jichi Medical University
2015-2024
Jichi Medical University Saitama Medical Center
2015-2024
Tokyo Women's Medical University Adachi Medical Center
2018-2024
Meijo University
2021-2023
Nagoya University
1990-2022
Tokyo Women's Medical University
2009-2022
North Carolina State University
2015-2018
Shonan Kamakura General Hospital
2013
Gifu Pharmaceutical University
2005-2012
Gifu University
2009-2012
This study aimed to use artificial intelligence (AI) predict the pathological diagnosis of ovarian tumors using patient information and data from preoperative examinations.A total 202 patients with were enrolled, including 53 cancer, 23 borderline malignant tumors, 126 benign tumors. Using 5 machine learning classifiers, support vector machine, random forest, naive Bayes, logistic regression, XGBoost, we derived diagnostic results 16 features, commonly available blood tests, background,...
Nuclear factor erythroid 2 (NF-E2)-related (Nrf2) is the master transcriptional regulator of antioxidant gene expression. On increased oxidative stress, an adaptor for Nrf2 degradation, Kelch-like ECH-associated protein 1 (Keap1), directly modulated by oxidants in cytoplasm, which results stabilization and activation Nrf2. also constitutively active, to some extent, absence exogenous stress. We have previously demonstrated that intestinal epithelium-specific TGF-β-activated kinase (TAK1)...
Abstract Postpartum hemorrhage is the leading cause of maternal morbidity. Clinical prediction postpartum remains challenging, particularly in case a vaginal birth. We studied machine learning models to predict hemorrhage. Women who underwent birth at Tokyo Medical University East Center between 1995 and 2020 were included. used 11 clinical variables defined as blood loss > 1000 mL. constructed five deep model consisting neural networks with two layers after applying ensemble classifiers,...
The methanolic extract of the roots Asiasarum sieboldi has been evaluated for anti-allergic effects on various experimental models in vitro and vivo. Bioassay-guided fractionation resulted isolation suppressive compounds PCA test: methyleugenol (1), elemicin (2), gamma-asarone (3), (-)-asarinin (4), (-)-sesamin (5). Furthermore, (2) (2E,4E,8Z,10E)-N-isobutyl-2,4,8,10-dodecatetraenami de (6) were found to exhibit an inhibitory action 5-lipoxygenase (5-LOX) from RBL-1 cells....
Intracellular iron is tightly regulated by coordinated expression of transport and storage genes, such as transferrin receptor-1 (TfR1) ferritin. They are primarily through iron-induced dissociation iron-regulatory proteins (IRPs) from iron-responsive elements (IREs) in the 3′-UTR (untranslated region) TfR1 or 5′-UTR ferritin mRNA, resulting destabilization mRNA release translation block. Thus high decreases via degradation increases translational up-regulation. However, molecular mechanism...
To clarify the contractile mechanism of Dai-kenchu-to, effects hydroxy beta-sanshool (an ingredient Zanthoxylum fruit), fruit (a constituent herb Dai-kenchu-to) and Dai-kenchu-to were studied in mucosa-free longitudinal muscle guinea pig ileum. Hydroxy at 10(-7)-10(-5) g/ml induced dose-related contractions accompanied by autonomous contraction produced an initial a concentration 10(-4) or more. The (10(-5) g/ml) was significantly inhibited tetrodotoxin capsaicin-receptor antagonist...
To confirm the usefulness of Dai-kenchu-to for intestinal obstruction, investigation effects on postoperative adhesion was conducted. Repeated administrations (100 or 300 mg/kg) significantly inhibited formation obstruction. Motor disturbance and inflammation are thought to be involved in etiology adhesion. A single treatment (300 reduce transit time ileus chemically induced ileus. (10(-4) g/ml) COX-2 activity. These results suggest that prevents by gastroprokinetic anti inflammatic effects....
Objective Most women with early stage endometrial cancer have a favorable prognosis. However, there is subset of patients who develop recurrence. In addition to the pathological stage, clinical and therapeutic factors affect probability Machine learning subtype artificial intelligence that considered effective for predictive tasks. We tried predict recurrence in using machine methods based on data. Methods enrolled 75 (International Federation Gynecology Obstetrics I or II) had received...
Patients with marked calcification of the basal ganglia and cerebellum have traditionally been referred to as having Fahr's disease, but nomenclature has criticized for including heterogeneous etiology. We describe 3 patients idiopathic bilateral striatopallidodentate calcinosis (IBSPDC). The were a 24-year-old man mental deterioration, 57-year-old parkinsonism dementia, 76-year-old woman dementia mild parkinsonism. former 2 showed severe cerebellum, latter patient cerebellum. found...