A5050203519- Regulation of Appetite and Obesity
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Inflammatory Bowel Disease
- Adipose Tissue and Metabolism
- Gastric Cancer Management and Outcomes
- Gastrointestinal motility and disorders
- Stress Responses and Cortisol
- Eosinophilic Esophagitis
- Biochemical Analysis and Sensing Techniques
- Microscopic Colitis
- Gastroesophageal reflux and treatments
- Gallbladder and Bile Duct Disorders
- Neuropeptides and Animal Physiology
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Pharmacological Effects of Natural Compounds
- Sleep and Wakefulness Research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Biochemical effects in animals
- Immunodeficiency and Autoimmune Disorders
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
Social Insurance Saitama Chuo Hospital
2013-2024
Saitama Medical University
2014-2024
Osaka Metropolitan University
2024
The Japanese Society of Gastroenterological Surgery
2015
Digestive Care (United States)
2011
Teikyo University
1994-2006
Tsumura Research Institute (Japan)
2001
BG University Hospital Bergmannsheil Bochum
1998
Third Way
1997
Technical University of Munich
1995
Caloric restriction (CR) is known to retard aging and delay functional decline as well the onset of diseases in most organisms. Ghrelin secreted from stomach response CR regulates energy metabolism. We hypothesized that ghrelin has a role protecting aging-related diseases. examined physiological mechanisms underlying system during process three mouse strains with different genetic biochemical backgrounds animal models accelerated or normal human aging. The elevated plasma concentration was...
Although chemotherapy with cisplatin is a widely used and effective cancer treatment, the undesirable gastrointestinal side effects associated it, such as nausea, vomiting, anorexia, markedly decrease patients’ quality of life. To elucidate mechanism underlying chemotherapy-induced focusing on hypothalamic ghrelin secretion-anorexia association, we measured secretion in fasted cisplatin-treated rats. Hypothalamic changes after vagotomy or administration cisplatin. Cisplatin + rikkunshito,...
Although it is known that urocortin 1 (UCN) acts on both corticotropin-releasing factor receptors (CRF(1) and CRF(2)), the mechanisms underlying UCN-induced anorexia remain unclear. In contrast, ghrelin, endogenous ligand for growth hormone secretagogue receptor, stimulates food intake. present study, we examined effects of CRF(1) CRF(2) receptor antagonists (CRF(1)a CRF(2)a) ghrelin secretion synthesis, c-fos mRNA expression in caudal brain stem, intake following intracerebroventricular...
To clarify the contractile mechanism of Dai-kenchu-to, effects hydroxy beta-sanshool (an ingredient Zanthoxylum fruit), fruit (a constituent herb Dai-kenchu-to) and Dai-kenchu-to were studied in mucosa-free longitudinal muscle guinea pig ileum. Hydroxy at 10(-7)-10(-5) g/ml induced dose-related contractions accompanied by autonomous contraction produced an initial a concentration 10(-4) or more. The (10(-5) g/ml) was significantly inhibited tetrodotoxin capsaicin-receptor antagonist...
The esophagus is the only organ where changes in superficial microvasculature from normal squamous epithelium to invasive cancer are evident by magnifying endoscopy. We investigated detail features of angiogenesis early-stage esophageal using CD34 and CD105 immunostaining, also correlation between mononuclear cell infiltration.Using 10 samples epithelium, 7 low-grade intraepithelial neoplasia, 45 cancer, we determined microvessel density at hot spots showing positive staining for CD105....
Using immunohistochemical staining, the present study was conducted to examine whether cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) affect angiogenesis in early-stage esophageal squamous cell carcinoma (ESCC). We also analyzed correlation between these two factors. Cyclooxygenase 2, iNOS, ESCC are unclear. 10 samples of normal epithelium, 7 low-grade intraepithelial neoplasia (LGIN), 45 superficial cancer, we observed expression COX-2 iNOS. then investigated iNOS...
Subcutaneous aseptic abscess is one phenotype of neutrophilic dermatitis. We were interested to see if a case steroid refractory Crohn's disease (CD) complicated by subcutaneous abscesses responds intensive granulocyte/monocyte adsorptive apheresis (GMA).The patient was 21-year-old male with worsening severe CD while on oral prednisolone (30 mg/day). His symptoms included fever, bloody diarrhoea and multiple painful nodules throughout his body. Skin biopsy showed chronic panniculitis...
The autonomic nervous system (ANS) conveys neuronal input from the brain to stomach. We investigated mechanisms through which urocortin 1 (UCN1) injected intracerebroventricularly (ICV, 300 pmol/rat) inhibits circulating ghrelin in rats. This was achieved by assessing (1) induction of c-fos gene expression as a marker activation specific hypothalamic and caudal brainstem regulating ANS; (2) influence vagotomy pharmacological blockade central peripheral α- β-adrenergic receptor (AR) on ICV...