A5073575033- Occupational and environmental lung diseases
- Plasma Applications and Diagnostics
- Clinical Nutrition and Gastroenterology
- Iron Metabolism and Disorders
- Trace Elements in Health
- Graphene and Nanomaterials Applications
- Retinal and Optic Conditions
- Plasma Diagnostics and Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Electrohydrodynamics and Fluid Dynamics
- Curcumin's Biomedical Applications
- Nanoparticles: synthesis and applications
- Retinal and Macular Surgery
- Aluminum toxicity and tolerance in plants and animals
- Heme Oxygenase-1 and Carbon Monoxide
- Surface Modification and Superhydrophobicity
- Intraocular Surgery and Lenses
- Hemoglobinopathies and Related Disorders
- Genomics, phytochemicals, and oxidative stress
- Ferroptosis and cancer prognosis
- Vitamin C and Antioxidants Research
- Burn Injury Management and Outcomes
- Pleural and Pulmonary Diseases
- Antenna Design and Analysis
- Congenital Diaphragmatic Hernia Studies
Nagoya University
2015-2024
Okayama University
2003-2021
Louisiana State University Health Sciences Center Shreveport
2006-2017
Kyoto Pharmaceutical University
2013
Aichi Cancer Center
2011
Molecular Oncology (United States)
2011
Texas A&M University
2011
College Station Medical Center
2011
Nagoya University Hospital
2011
The University of Texas Health Science Center at San Antonio
2011
Multiwalled carbon nanotubes (MWCNTs) have the potential for widespread applications in engineering and materials science. However, because of their needle-like shape high durability, concerns been raised that MWCNTs may induce asbestos-like pathogenicity. Although recent studies demonstrated various types reactivities, physicochemical features determine cytotoxicity carcinogenicity mesothelial cells remain unclear. Here, we showed deleterious effects nonfunctionalized on human were...
Abstract: Dietary antioxidants protect laboratory animals against the induction of tumours by a variety chemical carcinogens. Among possible mechanism protection carcinogenesis could be mediated via‐antioxidant‐dependent detoxifying enzymes. Curcumin, yellow pigment from Curcuma longa , is major component turmeric and commonly used as spice food colouring material exhibits antiinflammatory, antitumour, antioxidant properties. In this study we therefore investigated effect dietary...
Lung cancers with neuroendocrine (NE) features are often very aggressive but the underlying molecular mechanisms remain elusive. The transcription factor ASH1/ASCL1 is a master regulator of pulmonary NE cell development that involved in pathogenesis lung (NE-lung cancers). Here we report definition microRNA miR-375 as key downstream effector ASH1 function NE-lung cancer cells. was markedly induced by cells where it sufficient to induce differentiation. upregulation prerequisite for...
We have been developing novel ultrahigh density atmospheric pressure plasma sources and succeeded in the selective killing ovarian cancer cells against normal ones. Furthermore, we found out plasma-activated medium (PAM) also killed glioblastoma brain tumor selectively ones chemical products PAM long lifetime healing effects. To clarify mechanism, interactions of with organism where belongs were investigated on viewpoint intracellular molecular mechanism.
Iron overload has been associated with carcinogenesis in humans. Intraperitoneal administration of ferric nitrilotriacetate initiates a Fenton reaction renal proximal tubules rodents that ultimately leads to high incidence cell carcinoma (RCC) after repeated treatments. We performed high-resolution microarray comparative genomic hybridization identify characteristics the profiles this oxidative stress-induced rat RCCs. The results revealed extensive large-scale alterations preference for...
Abstract Exposure to asbestos is a risk for malignant mesothelioma (MM) in humans. Among the commercially used types of (chrysotile, crocidolite, and amosite), carcinogenicity chrysotile not fully appreciated. Here, we show that all three similarly induced MM rat peritoneal cavity caused earliest development with high fraction sarcomatoid histology. The pathogenesis chrysotile‐induced mesothelial carcinogenesis was closely associated iron overload: repeated administration an chelator,...
Asbestos is a potent carcinogen associated with increased risks of malignant mesothelioma and lung cancer in humans. Although the mechanism carcinogenesis remains elusive, physicochemical characteristics asbestos play role progression asbestos-induced diseases. Among these characteristics, high capacity to adsorb accommodate biomolecules on its abundant surface area has been linked cellular genetic toxicity. Several previous studies identified asbestos-interacting proteins. Here, use...
Abstract Non-thermal atmospheric pressure plasma has been widely used for preclinical studies in areas such as wound healing, blood coagulation, and cancer therapy. We previously developed plasma-activated medium (PAM) Ringer’s lactate solutions (PAL) treatments. Many vitro vivo experiments demonstrated that both PAM PAL exhibit anti-tumor effects several types of cells ovarian, gastric, pancreatic well glioblastoma cells. However, interestingly, induces more intracellular reactive oxygen...
Thermal plasmas and lasers are used in medicine to cut ablate tissues for coagulation. Non-equilibrium atmospheric pressure plasma (NEAPP) is a recently developed, non-thermal technique with possible biomedical applications. Although NEAPP reportedly generates reactive oxygen/nitrogen species, electrons, positive ions, ultraviolet radiation, little research has been done into the use of this conventional free radical biology. Recently, we developed device high electron density. Electron spin...
Multiwalled carbon nanotubes ( MWCNTs ) have attracted public attention not only for their potential applications in engineering and materials science but also possible environmental risks. share similar properties with asbestos, a definite human carcinogen causing malignant mesothelioma MM ), that they are both biopersistent thin fibers high aspect ratio. Certain types of do induce animal experiments. Though there many different awaiting use industry, is little evidence about what present...
Asbestos is still a social burden worldwide as carcinogen causing malignant mesothelioma. Whereas recent studies suggest that local iron reduction preventive strategy against carcinogenesis, little known regarding the cellular and molecular mechanisms surrounding excess iron. Here by differentially using high-risk low-risk asbestos fibers (crocidolite anthophyllite, respectively), we identified asbestos-induced mutagenic milieu for mesothelial cells. Rat cell experiments revealed...
Abstract Low-temperature plasma is being widely used in the various fields of life science, such as medicine and agriculture. Plasma-activated solutions have been proposed potential cancer therapeutic reagents. We previously reported that plasma-activated Ringer’s lactate solution exhibited selective cancer-killing effects, plasma-treated L-sodium was an anti-tumor factor; however, components are generated through interactions between responsible for killing cells remain unidentified. In...
Asbestos was used worldwide in huge quantities the past century. However, because of unexpected carcinogenicity to mesothelial cells with an extremely long incubation period, many countries face this long-lasting social problem. Mesothelioma is often diagnosed advanced stage, for which no effective therapeutic protocols are yet established. We previously reported on basis animal experiments that major pathology asbestos-induced carcinogenesis local iron overload. Here, we undertook find...
Multi-wall carbon nanotubes (MWCNT) are a form of flexible fibrous nanomaterial with high electrical and thermal conductivity. However, 50-nm MWCNT in diameter causes malignant mesothelioma (MM) rodents and, thus, the International Agency Research on Cancer has designated them as possible human carcinogen. Little is known about molecular mechanism through which MM. To elucidate carcinogenic mechanisms mesothelial cells, we used variety lysates to comprehensively identify proteins...
Asbestos exposure is considered a social burden by causing mesothelioma. Despite the use of synthetic materials, multi-walled carbon nanotubes (MWCNTs) are similar in dimension to asbestos and produce mesothelioma animals. The role inflammatory cells mesothelial carcinogenesis remains unclear. Here, we evaluated differences cell responses following these fibrous materials using luminometer L-012 (8-amino-5-chloro-7-phenylpyrido[3,4-d]pyridazine-1,4-(2H,3H) dione) detect reactive oxygen...
Due to the formerly widespread use of asbestos, malignant mesothelioma (MM) is increasingly frequent worldwide. MM classified into epithelioid (EM), sarcomatoid (SM), and biphasic subtypes. SM less common than EM but recognized as most aggressive type MM, these patients have a poor prognosis. To identify genes responsible for aggressiveness SM, we induced in rats, using compared their transcriptomes. Based on results, focused connective tissue growth factor (Ctgf), whose expression was...
A number of investigations have implicated the involvement free radicals in various pathogenic process including initiation/promotion stages carcinogenesis and antioxidants been considered to be a protective agent for this reason. An iron chelate, ferric nitrilotriacetate (Fe-NTA), is potent nephrotoxic induces acute subacute renal proximal tubular necrosis by catalyzing decomposition hydrogen peroxide–derived production hydroxyl radicals, which are known cause lipid peroxidation DNA damage....