A5055664156- Dermatology and Skin Diseases
- Skin and Cellular Biology Research
- Urticaria and Related Conditions
- Contact Dermatitis and Allergies
- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Nicotinic Acetylcholine Receptors Study
- Psoriasis: Treatment and Pathogenesis
- Antimicrobial Peptides and Activities
- Nail Diseases and Treatments
- Plant Reproductive Biology
- Barrier Structure and Function Studies
- Proteins in Food Systems
- Otitis Media and Relapsing Polychondritis
- Allergic Rhinitis and Sensitization
- Systemic Lupus Erythematosus Research
- Advancements in Transdermal Drug Delivery
- Mast cells and histamine
- Eosinophilic Disorders and Syndromes
- Chronic Myeloid Leukemia Treatments
- Food Allergy and Anaphylaxis Research
- Genetic and rare skin diseases.
- Wound Healing and Treatments
- Wnt/β-catenin signaling in development and cancer
- Hair Growth and Disorders
Asahikawa Medical University
2015-2024
Wakayama Medical University
2024
Loyola University Chicago
2015-2019
Asahikawa Medical College Hospital
2003-2010
Asahikawa City Hospital
2010
Pustulosis palmaris et plantaris (PPP) and pustulotic arthro-osteitis (PAO) are tonsil-related diseases. Treatment outcome of tonsillectomy prognostic factors influencing the have not been analyzed quantitatively. We evaluated those using Palmoplantar Area Severity Index (PPPASI). At 1, 3, 6, 12, 24 more than months post-tonsillectomy, 20 (31%), 34 (48%), 70 (60%), 57 (80%), 36 (95%) 23 (96%) patients realized 80% or improvement PPP skin lesions, respectively, eight (17%), (36%), 30 (50%),...
Abstract Objectives To efficiently detect somatic UBA1 variants and establish a clinical scoring system predicting patients with pathogenic in VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome. Methods Eighty-nine Japanese clinically suspected syndrome were recruited [81 males 8 females; median age of onset 69.3 years (interquartile range 62.1–77.6)]. Peptide nucleic acid–clamping PCR (PNA-PCR), regular targeting exon 3 clustering subsequent Sanger sequencing...
Abstract: To maintain stratum corneum integrity while simultaneously desquamating at a steady rate, degradation of corneodesmosomes must proceed in controlled manner. It is unknown why are present only the cell periphery upper corneum. explore this, we studied distributions three major corneodesmosomal components, corneodesmosin, desmoglein 1 and desmocollin normal adult human epidermis. Immunofluorescent microscopy studies skin surface corneocytes detected all components edges....
Kallikrein type serine proteases, KLK8/neuropsin, KLK6, and KLK7, have been implicated in the proliferation differentiation of epidermal keratinocytes pathogenesis psoriasis. However, their mechanistic roles these processes remain largely unknown. We applied 12-O-tetradecanoylphorbol-13-acetate on wild (WT) Klk8 gene-disrupted (Klk8(-/-)) mouse skin, inducing keratinocyte similar to human psoriatic lesion. mRNA as well Klk6 Klk7 were up-regulated after application WT mice. In contrast,...
Defects in epidermal barrier function and/or vesicular transport underlie severe skin diseases including ichthyosis and atopic dermatitis. Tight junctions (TJs) form a single layered network simple epithelia. TJs are important for both functions transport. Epidermis is stratified epithelia lamellar granules (LGs) secreted from the stratum granulosum (SG) sequential manner. Previously, continuous paracellular permeability barriers were found second layer (SG2) of SG mice, but their fate...
Abstract Palmoplantar pustulosis ( PPP ) and pompholyx are both chronic relapsing diseases occurring on the palms soles. Although these two have been considered completely different from each other, it is sometimes very difficult even for dermatologists to differentiate them other because of their similarities in clinical presentation. In this study, we aimed analyze histopathological features find out “clues” between by features. The histopathology 11 six patients, who were diagnosed with...
One of the major adverse effects topical glucocorticoids is cutaneous atrophy often followed by development resistance to steroids (tachyphylaxis). Previously we showed that after two weeks, interfollicular mouse keratinocytes acquired anti-proliferative glucocorticoid fluocinolone acetonide (FA). top genes activated FA during tachyphylaxis was Klk6 encoding kallikrein-related peptidase 6, known enhance keratinocyte proliferation. KLK6 also strongly induced chronic in human skin. Double...
Abstract Azathioprine ( AZA )‐metabolizing enzyme gene polymorphism is strongly related to thiopurine‐induced leukocytopenia, which has not been well recognized in dermatological practice. We tried see whether NUDT 15 can be the most susceptible genetic factor for toxicity and screening beneficial avoid adverse events of treatment skin diseases. A retrospective study was carried out on adult Japanese patients who were treated with . Gene thiopurine‐metabolizing enzymes R139C, ITPA 94C>A,...