A5012467429- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Musculoskeletal synovial abnormalities and treatments
- Inflammatory Myopathies and Dermatomyositis
- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Biosimilars and Bioanalytical Methods
- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bone and Joint Diseases
- Immunodeficiency and Autoimmune Disorders
- Viral Infections and Immunology Research
- Liver Diseases and Immunity
- Peripheral Neuropathies and Disorders
- IgG4-Related and Inflammatory Diseases
- Neurogenetic and Muscular Disorders Research
- Reproductive System and Pregnancy
- Autoimmune and Inflammatory Disorders Research
- Chronic Lymphocytic Leukemia Research
- Patient-Provider Communication in Healthcare
- Eosinophilic Disorders and Syndromes
- Vasculitis and related conditions
- Vascular Malformations and Hemangiomas
Yokohama City University
2015-2024
Yokohama City University Medical Center
2021-2024
Immune Regulation (United Kingdom)
2017
Park University
1995
Advisory Board Company (United States)
1995
Interstitial lung disease (ILD) is the principal cause of death in polymyositis/dermatomyositis (PM/DM). Here we investigated prognostic factors for and serious infection PM/DM-ILD using multicenter database. We retrospectively reviewed baseline demographic, clinical laboratory findings, treatment regimens outcomes patients with PM/DM-ILD. The distribution ILD lesions was evaluated four divided zones high-resolution computed tomography images. Of 116 PM/DM-ILD, 14 died within 6 months from...
Journal Article Ultrasonography is a potent tool for the prediction of progressive joint destruction during clinical remission rheumatoid arthritis Get access Ryusuke Yoshimi, Yoshimi Department Internal Medicine and Clinical Immunology, Yokohama City University Graduate School Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Japan Search other works by this author on: Oxford Academic Google Scholar Maasa Hama, Hama Kaoru Takase, Takase Atsushi Ihata, Ihata Daiga Kishimoto, Kishimoto Kayo...
Journal Article Ultrasonography is a potent tool for the prediction of progressive joint destruction during clinical remission rheumatoid arthritis Get access Ryusuke Yoshimi, Yoshimi Department Internal Medicine and Clinical Immunology, Yokohama City University Graduate School Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Japan Search other works by this author on: Oxford Academic Google Scholar Maasa Hama, Hama Kaoru Takase, Takase Atsushi Ihata, Ihata Daiga Kishimoto, Kishimoto Kayo...
Abstract Objectives To efficiently detect somatic UBA1 variants and establish a clinical scoring system predicting patients with pathogenic in VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome. Methods Eighty-nine Japanese clinically suspected syndrome were recruited [81 males 8 females; median age of onset 69.3 years (interquartile range 62.1–77.6)]. Peptide nucleic acid–clamping PCR (PNA-PCR), regular targeting exon 3 clustering subsequent Sanger sequencing...
Innate immunity including macrophages (Mϕ) in lupus nephritis (LN) has been gaining attention, but roles of Mϕ LN remain uncertain. Immunohistochemical staining was performed to determine CD68, CD163, heme oxygenase (HO)-1 (a stress-inducible heme-degrading enzyme with anti-inflammatory property), pSTAT1, and CMAF-expressing the glomeruli patients LN. Effects type I interferons on expression levels HO-1, BTB CNC homology 1 (Bach1; a transcriptional HO-1 repressor), interleukin (IL)-6, IL-10...
TRIM21 is one of the autoantigens that reacts with an anti-SS-A antibody (Ab) present in patients systemic lupus erythematosus (SLE) and Sjögren's syndrome. thought to play a role B-cell proliferation apoptosis, among other activities. Here we examined pathological SLE. Trim21-deficient MRL/lpr mice were generated by backcrossing C57BL/6 mice. The levels serum anti-dsDNA Ab urine protein at 28 weeks age significantly higher as compared wild-type (p = 0.029 0.003, respectively). Resting B...
To compare the findings in rheumatoid arthritis (RA)-affected joints between (18)F-fluorodeoxyglucose (FDG) and (18)F-fluoride (NaF) positron emission tomography (PET)/computed (CT).We enrolled twelve RA patients who started a new biologic agent (naïve 9 switch 3). At entry, both hands were examined by (18)F-FDG PET/CT, (18)F-NaF X-ray. Intensity of PET signals was determined standardized uptake value max (SUVmax) metacarpophalangeal (MCP), proximal interphalangeal (PIP), ulnar, medial,...
Journal Article A novel 8-joint ultrasound score is useful in daily practice for rheumatoid arthritis Get access Ryusuke Yoshimi, Yoshimi Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School Medicine, Yokohama, Japan Search other works by this author on: Oxford Academic Google Scholar Atsushi Ihata, Ihata JapanDepartment Rheumatology, Minami Kyosai Hospital, Yosuke Kunishita, Kunishita Daiga Kishimoto, Kishimoto Reikou Kamiyama, Kamiyama Kaoru...
Objectives: TRIM21 is an E3 ubiquitin ligase for interferon regulatory factors (IRFs) that are involved in innate and acquired immunity. Here, we evaluated the role of (IFN) signature systemic lupus erythematosus (SLE). Methods: Twenty SLE patients 24 healthy controls were enrolled this study. We analyzed mRNA expression TRIM21, type I IFN, IFN-inducible genes peripheral blood mononuclear cell (PBMC). The protein levels IRFs assessed by Western blotting PBMCs cultured with or without MG-132....
Infection is a leading cause of death in patients with systemic lupus erythematosus (SLE). Alt hough hydroxychloroquine (HCQ) has been reported to inhibit infection, evidence from Asian populations remains insufficient. We investigated this effect Japanese SLE patients.Data the Lupus Registry Nationwide Institutions were used study. The ≥20 years old and met American College Rheumatology (ACR) classification criteria revised 1997. defined "severe infections" as those requiring...
Objectives: Although intensive immunosuppressive treatment is necessary for the severe cases with polymyositis (PM)/dermatomyositis (DM), prognostic factors or disease activity indices PM/DM have not been established. Here we investigated association between serum microRNA-1 (miR-1) level and clinical course of patients PM/DM. Methods: We retrospectively reviewed baseline laboratory findings, regimens outcomes in The samples were collected from healthy controls (HC). Serum miR-1 levels...
TRIM21 is a member of the tripartite motif family proteins and one autoantigens which react with anti-SS-A antibody (Ab) present in sera patients systemic lupus erythematosus (SLE) Sjögren's syndrome. Previous studies have shown that dysfunction promotes aberrant B-cell differentiation Ab production SLE, anti-TRIM21 may be related to human SLE pathogenesis. Here, we examined relationship between clinical immunological characteristics patients.Twenty-seven (23 women four men) before...
To determine whether ultrasonography (US) predicts Boolean remission in rheumatoid arthritis (RA) patients who had achieved disease activity score 28 joints (DAS28)-based criteria.Thirty-one RA DAS28-based clinical were recruited. US semiquantitatively determined Gray scale (GS) and power Doppler (PD) signal scores the bilateral wrists all metacarpophalangeals proximal interphalangeals. Total GS total PD calculated as sum of individual for each joint.Among 22 patients, maintained DAS28 2...
To determine combined evaluation of musculoskeletal ultrasonography (MSUS) and power Doppler (PD) signals, anti-citrullinated peptide antibody (ACPA), other clinical findings improve the prediction joint destruction in rheumatoid arthritis (RA).We performed a retrospective study 331 RA patients (female n = 280 male 51, mean age: 57.9 ± 13.2 years) who underwent MSUS from 2002 to 2012. Correlations with progression destructions 1,308 2nd 3rd metacarpophalangeal (MCP) joints various factors...
To clarify the use of musculoskeletal ultrasonography (US) ankle joints in rheumatoid arthritis (RA).Consecutive RA patients with or without symptoms participated study. The US, clinical examination (CE), and patients' visual analog scale for pain (pVAS) ankles were assessed. Prevalence tibiotalar joint synovitis tenosynovitis assessed by grayscale (GS) power Doppler (PD) US using a semi-quantitative grading (0-3). positive CE findings defined as GS score ≥2 and/or PD ≥1, swelling...
Objectives: To investigate whether on-demand ultrasonography (US) assessment alongside a routine examination is useful in the management of rheumatoid arthritis (RA). Methods: US was performed eight (bilateral MCP 2, 3, wrist and knee) joints as cumulative total 406 RA patients. The most symptomatic joint other than additionally scanned. Power Doppler (PD) gray-scale images were scored semiquantitatively. Eight-joint scores calculated sum individual for joints. Results: found among 209...
Multifocal fibrosclerosis (MFS), which causes systemic and chronic connective tissue inflammation, has been associated with IgG4 regarded as an identical entity "IgG4-related disease (IgG4-RD)". Although a few cases of MFS mimicking IgG4-RD histopathologically, despite the absence serum elevation IgG4-positive plasma cell infiltration, have reported, there is, so far, little information regarding such exceptional cases. We herein demonstrate case non-IgG4-related presenting periaortitis...
Optic perineuritis (OPN), which is an inflammatory disorder affecting the optic nerve sheath, one of rare complications in granulomatosis with polyangiitis (GPA). Although several groups have reported that immunosuppressive therapies are generally effective against GPA-associated OPN, so far, there little information as to other options for refractory cases. Here we demonstrate a case potent therapy including high-dose glucocorticoid, intravenous cyclophosphamide and rituximab therapy,...
ABSTRACT Objectives Few studies have explored whether the involvement of patients in shared decision-making (SDM) is beneficial to management systemic lupus erythematosus (SLE). Therefore, this study investigated relationship between patient participation SDM and their trust physicians using data from TRUMP2-SLE study. Methods Data regarding nine-item Shared Decision-Making Questionnaire (SDM-Q-9 scores), Trust Physician Scale (TIPS) scores, Abbreviated Wake Forest (A-WFPTS) scores for...
Few studies have explored whether the involvement of patients in shared decision-making (SDM) is beneficial to management systemic lupus erythematosus (SLE). Therefore, this study investigated relationship between patient participation SDM and their trust physicians using data from Trust Measurement Physicians Patients With SLE (TRUMP2-SLE) study.
Objective Late-onset systemic lupus erythematosus (LoSLE) is known to possess characteristics different from those of early-onset SLE (EoSLE), thereby making their diagnosis difficult. This study aimed assess the characteristic features LoSLE in Japan, a model country with super-aged society. Methods Data were obtained Lupus Registry Nationwide Institutions, which includes multicenter cohort patients Japan who satisfied 1997 American College Rheumatology revised classification criteria for...
Haemophagocytic syndrome (HPS) is one of the most severe complications systemic lupus erythematosus (SLE). Although corticosteroids are usually selected as an initial treatment, some patients corticosteroid-resistant and require additional immunosuppressants. Here, we report a case SLE-associated HPS patient who was resistant to prednisolone, calcineurin inhibitors, cyclophosphamide, plasma exchange infliximab but successfully treated with mycophenolate mofetil (MMF). MMF could be...
Disseminated nontuberculous mycobacterial infection (DNTM) is typically observed in immunocompromised hosts. Recently, it has been reported that healthy individuals with serum neutralizing autoantibodies for interferon (IFN)-γ can also develop DNTM. We herein report a case of anti-IFN-γ antibody-seropositive DNTM caused by Mycobacterium kansasii symptoms mimicking TAFRO or POEMS syndrome, including anasarca, organomegaly, skin pigmentation, polyneuropathy, osteosclerotic change,...
Abstract Aim To determine characteristics of rheumatoid arthritis (RA) patients in Japan who received the same biological disease‐modifying antirheumatic drugs (bDMARDs) for at least 6 months and to identify factors associated with successful down‐titration bDMARDs dependent on shared decision‐making. Methods We included consecutive RA bDMARD low disease activity or remission our two university hospitals. Patients treated standard dose were defined as SD, while those DT. retrospectively...
<h3>Background</h3> Musculoskeletal ultrasonography (US) is one of the standard tools for diagnosis and monitoring rheumatoid arthritis (RA). Although we other groups have proposed several sets US assessment procedures in arbitrary combinations selected joints,<sup>1–3</sup> there still no consensus defining joints to evaluate. <h3>Objectives</h3> To investigate whether 8 which advocate as a routine useful response treatment RA. <h3>Methods</h3> Power Doppler (PD) was performed 24 joints,...