A5000891376- Rheumatoid Arthritis Research and Therapies
- Osteoarthritis Treatment and Mechanisms
- Spine and Intervertebral Disc Pathology
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Cell death mechanisms and regulation
- Musculoskeletal pain and rehabilitation
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Spinal Fractures and Fixation Techniques
- T-cell and B-cell Immunology
- Cardiac Imaging and Diagnostics
- interferon and immune responses
- Nutrition and Health in Aging
- Cervical and Thoracic Myelopathy
- Systemic Lupus Erythematosus Research
- Cancer survivorship and care
- Liver physiology and pathology
- Cancer-related Molecular Pathways
- Autoimmune and Inflammatory Disorders Research
- NF-κB Signaling Pathways
- Infectious Diseases and Tuberculosis
- Protein Kinase Regulation and GTPase Signaling
- Cardiac Arrhythmias and Treatments
Kobe University
2016-2025
Hyogo University of Health Sciences
2009-2025
National Center for Global Health and Medicine
2017-2018
Waseda University
2017-2018
Center for Global Health
2018
Kobe University Hospital
2003-2017
Center for Rheumatology
2016-2017
The University of Tokyo
2015
Toyohashi Municipal Hospital
2003-2013
RMIT University
2013
The possibility that activated B cells might express a ligand for CD40 was of functional importance cell responses examined by using highly purified human peripheral blood cells, as well variety lymphoblastoid lines and hybridomas. Following stimulation with the combination calcium ionophore phorbol ester, bound soluble fusion protein containing extracellular portion Fc region IgG1 (CD40.Ig). A hybridomas also CD40.Ig, either constitutively or after activation. In addition, CD40.Ig...
Postoperative pulmonary complications (PPCs) after esophagectomy have been reported to occur in 15.9-30% of patients and lead increased postoperative morbidity mortality, prolonged duration hospital stay, additional medical costs. The purpose this retrospective cohort study was investigate the possible prevention PPCs by intensive preoperative respiratory rehabilitation esophageal cancer who underwent esophagectomy. subjects included 100 (87 males 13 females with mean age 66.5 ± 8.6 years)...
Abstract Objective To examine the promoter activity and protein expression of death receptor 3 gene DR3 , a member apoptosis‐inducing Fas family, with particular reference to methylation status its region in rheumatoid arthritis (RA). Methods Genomic DNA was prepared from peripheral blood mononuclear cells obtained healthy individuals patients RA synovial osteoarthritis. The analyzed by bisulfite genomic sequencing methylation‐specific polymerase chain reaction techniques. Gene were examined...
rho GDP dissociation inhibitor (GDI) is an inhibitory GDP/GTP exchange protein for a group of small GTP-binding proteins including at least rhoA p21, rhoB rac1 rac2 and G25K. Microinjection GDI into Swiss 3T3 cells made the round refractile. This morphological change was accompanied by disappearance stress fibers. The action prevented comicroinjection with guanosine 5'-(3-O-thio)triphosphate (GTP gamma S)-bound form but not GTP S-bound p21 lacking C-terminal three amino acids, which...
In this study, we assessed the validity of a subjective histological-histochemical scoring system as compared to an automated histomorphometry program for analyzing cartilage repair tissue. first part ability human eye estimate percent in histological section. Twenty-nine rabbit periosteal explants that had been cultured agarose transforming growth factor-beta (TGF-beta) were selected so percentage specimens was distributed equally from 0% 100%. Color photomicrographs evaluated by 5 expert...
Microinjection of either Ki-rasVal-12 p21 or the GDP-bound form Ki-ras plus smg GDP dissociation stimulator (GDS), a stimulatory GDP/GTP exchange protein for p21, smg/rap1/Krev-1 and rho into quiescent Swiss 3T3 cells induced DNA synthesis irrespective presence absence insulin. The guanosine 5'-(3-O-thio)triphosphate (GTP gamma S)-bound p21B GDS also but only in Either same alone was inactive, slightly active morphology analyzed by scanning electron, phase-contrast, confocal laser...
Object The purpose of this study was to provide the first evidence for image classification idiopathic spinal cord herniation (ISCH) in a multicenter study. Methods Twelve patients who underwent surgery ISCH were identified, and preoperative symptoms, severity paralysis myelopathy, disease duration, plain radiographs, MR imaging CT myelography findings, surgical procedure, intraoperative data from monitoring, postoperative recovery investigated these patients. Findings on sagittal classified...
To develop a culture system for large-scale production of mature hepatocytes, liver progenitor cells (LPCs) with high proliferation potential would be advantageous. We have found that carboxypeptidase M (CPM) is highly expressed in embryonic LPCs, hepatoblasts, while its expression decreased along hepatic maturation. Consistently, CPM was transiently induced during specification from human-induced pluripotent stem (hiPSCs). CPM+ isolated differentiated hiPSCs at the immature hepatocyte stage...
In Brief Study Design. A prospective minimum 5-year follow-up study of the cervical spine in patients with rheumatoid arthritis (RA) initially without involvement. Objective. To clarify incidence and aggravation instabilities their predictive risk factors RA. Summary Background Data. Many reports have shown progression involvement However, few articles described comprehensive evaluation its prognostic factors. Methods. total 140 "definite" or "classical" RA were prospectively followed for...
We report a case of 42-year-old woman who developed fine motor dysfunction after decompressive craniectomy for traumatic brain injury (TBI), despite the absence obvious lesions on conventional magnetic resonance imaging (MRI) to explain deficits. Following cranioplasty, diffusion tensor (DTI) revealed an increase in fractional anisotropy (FA) primary cortex, which correlated with significant improvement function. These findings highlight DTI's potential as valuable tool capturing subtle...
Periosteum has been shown in vitro and vivo to have a chondrogenic potential that permits it be used for cartilage regeneration. A useful donor site should good potential, availability of large quantity periosteum, relative ease access, associated with low rate morbidity. We hypothesized the periosteum varies from one bone another among different regions single bone. total 370 periosteal 37 fascia lata (control) explants were taken skull, ilium, scapula, upper, middle, lower medial proximal...
Transforming growth factor-beta 1 (TGF-beta 1) has been shown to stimulate chondrogenesis in periosteal explants cultured agarose suspension. In this study, the dose-response curve for such enhancement was measured. Periosteal and fascia lata were harvested from two-month-old rabbits, six weeks with 0, 0.1, 1, 5, 10, 50, or 100 ng/mL TGF-beta suspension, then analyzed by histomorphometry quantitative collagen typing. Cartilage produced seven of 11 (64%) control suspension without 1. enhanced...
Abstract Positive and negative effects of CD40 ligation on human B cell function were suggested by the observation that mAb to ligand partially blocked suppressive influences anti-CD3-stimulated control CD4+ T cells, as well stimulatory anti-CD3 activated mitomycin C-treated cells. To examine in greater detail, cells cultured with expressed optimal levels ligand; additional recombinant significantly suppressed Ig production, but not proliferation. In contrast, when stimulated SAC...
Abstract Objective Decoy receptor 3 (DcR3), a newly identified member of the tumor necrosis factor (TNFR) superfamily, is soluble that binds to members TNF family, including FasL, LIGHT, and TNF‐like molecule 1A. DcR3 mostly expressed in cells, it competitively inhibits binding TNFRs. The present study was undertaken investigate expression fibroblast‐like synoviocytes (FLS) from patients with rheumatoid arthritis (RA) osteoarthritis (OA), analyze effects on Fas‐induced apoptosis RA FLS....
CD40 engagement induces a variety of functional outcomes following association with adaptor molecules the TNF receptor-associated factor (TRAF) family. Whereas TRAF2, -5, and -6 initiate NF-kappaB activation, TRAF3-initiated signaling are less characterized. To delineate CD40-induced TRAF3-dependent events, Ramos B cells stably transfected dominant negative TRAF3 were stimulated membranes expressing recombinant CD154/CD40 ligand. In absence signaling, activation p38 control Ig production...
Radiographic evaluation of bony union and clinical outcome were investigated after posterior lumbar interbody fusion (PLIF) performed with only local bone.To examine the viability bone for graft in PLIF.Different sources have been used PLIF. Autologous iliac is most likely suitable biologic healing ability, but there may be some questions such as donor site pain. Allograft artificial bones are less effective healing. Use could a solution. However, quality still being questioned hesitation to...