A5050971421- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Esophageal Cancer Research and Treatment
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Vitamin C and Antioxidants Research
- Gastrointestinal Tumor Research and Treatment
- Antioxidant Activity and Oxidative Stress
- Respiratory and Cough-Related Research
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Vitamin K Research Studies
- Pancreatic and Hepatic Oncology Research
- Cardiovascular Health and Disease Prevention
- Lung Cancer Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Sodium Intake and Health
- Cancer Treatment and Pharmacology
- Chemical synthesis and alkaloids
- Cardiovascular Disease and Adiposity
- Neuroendocrine Tumor Research Advances
Kyorin University
1988-2025
Osaka Rosai Hospital
2024-2025
Osaka Ekisaikai Hospital
2023-2025
Tochigi Cancer Center
2020-2025
Kanazawa University
2018-2025
National Cancer Center Hospital East
2023
Kanagawa Cancer Center
2023
University of Tsukuba
2023
Kyushu University
1992-2022
Japan Aerospace Exploration Agency
2022
AN amino acid, 3,5-dihydroxyphenylglycine (DHPG) induced current responses in Xenopus oocytes expressing a metabotropic glutamate receptor clone mGluRl. Apparent EC50 of DHPG for mGluRl was slightly lower than that (±)-l-aminocyclopentane-trans-l,3-dicarboxylic acid (ACPD). were partially inhibited by 2-amino-3-phosphonopropionic (AP-3). had no effect on ionotropic receptors whose expression the following injection poly(A)+ mRNA rat brains. In hippocampal slices, produced slow excitation...
To characterize thyroid hormone action on the ovary, direct effects of T4 or T3 were investigated in vitro using a monolayer culture system porcine granulosa cells. Monolayer cultures maintained for 6 days 4% serumsupplemented medium absence presence FSH (20 ng/ml), with without graded doses T3. Combined treatment and (10-7 M) induced morphological alternation resembling epitheloid cells, while alone failed to bring about morphology. Concomitant markedly increased FSH-stimulated induction...
Journal Article Induction of Differentiated Trophoblast Function by Epidermal Growth Factor: Relation Immunohistochemically Detected Cellular Factor Receptor Levels Get access TAKESHI MARUO, MARUO 1Department Obstetrics and Gynecology, Kobe University School Medicine Kobe, Japan Search for other works this author on: Oxford Academic Google Scholar HIROYA MATSUO, MATSUO TETSUYA OISHI, OISHI MASATO HAYASHI, HAYASHI RIICHIRO NISHINO, NISHINO MATSUTO MOCHIZUKI The Clinical Endocrinology &...
In a double-blinded randomized controlled trial, we investigated the long-term effect of vitamin C supplementation on blood pressure. A total 439 Japanese subjects with atrophic gastritis initially participated in trial using and β-carotene to prevent gastric cancer. Before early termination supplementation, 134 dropped out this whereas 120 124 took supplement daily at either 50 mg or 500 mg, respectively, for 5 years. neither systolic nor diastolic pressure was significantly related serum...
<i>Background and Purpose:</i> Stroke risk factors differ depending on the subtype of stroke; moreover, distribution risks is different among countries races. <i>Methods:</i> Mass health screening data were collected from Akita Prefectural Federation Agricultural Cooperative for Health Welfare 1991 to 1998. Cerebrovascular events determined stroke registry 2001. Then, clinical stroke, such as hypertension, hyperlipidemia diabetes mellitus, assessed in subtypes stroke....
Objective To assess whether dietary intervention in free-living healthy subjects is effective improving blood pressure levels. Design Open randomised, controlled trial. Setting Free-living two rural villages north-eastern Japan. Participants Five hundred and fifty volunteers aged 40–69 years. Interventions Tailored education to encourage a decrease sodium intake an increase the of vitamin C carotene, fruit vegetables. Main outcome measures Blood pressure, urinary excretion sodium, carotene...
A randomized double-blind intervention trial was done in Huixian, People's Republic of China, a population with high incidence esophageal cancer. The aim the to determine whether once-a-week treatment retinol (15 mg or 50,000 IU), riboflavin (200 mg), and zinc (50 mg) could result, after 1 year, lower prevalence precancerous lesions esophagus group receiving active as compared placebo. results trial, published elsewhere, indicated that had no effect on esophagus. In determining an be...
Gastric cancer (GC) has benefited from treatment improvements such as minimally invasive surgery, molecular-targeted drugs, and immune check point inhibitors. However, the prognosis of advanced GC is still unfavorable. Minimally pre-treatment detection drug sensitivity (MI-PDDS) increasing importance in view improved chemotherapy. biopsy specimens are obtained with relative ease but have not been considered an appropriate source for generating cell lines because their minute amounts. We...
We report a case of 42-year-old woman who developed fine motor dysfunction after decompressive craniectomy for traumatic brain injury (TBI), despite the absence obvious lesions on conventional magnetic resonance imaging (MRI) to explain deficits. Following cranioplasty, diffusion tensor (DTI) revealed an increase in fractional anisotropy (FA) primary cortex, which correlated with significant improvement function. These findings highlight DTI's potential as valuable tool capturing subtle...
<title>Abstract</title> <bold>Background:</bold> Glucose transporter 1 (GLUT1) is known to play a crucial role in glucose uptake malignant tumors. GLUT1 inhibitors reportedly exhibit anti-tumor effects by suppressing cancer cell proliferation. BAY-876, selective inhibitor, has been shown inhibit tumor growth ovarian and breast cancers. In this study, we investigated the anti-proliferative of BAY-876 treatment human colorectal (CRC) lines. <bold>Methods:</bold> We metabolic changes on...
Biliary tract cancer (BTC) remains among the most challenging malignancies with a poor prognosis and limited treatment options, particularly in pretreated patients. As patients experience disease progression after first-line treatment, effective second-line subsequent treatments are required. Although addition of modified FOLFOX (fluorouracil, leucovorin, oxaliplatin) to active symptom control improved overall survival progressing advanced BTC despite gemcitabine plus cisplatin its efficacy...
Glucose transporter 1 (GLUT1) is known to play a crucial role in glucose uptake malignant tumors. GLUT1 inhibitors reportedly exhibit anti-tumor effects by suppressing cancer cell proliferation. BAY-876, selective inhibitor, has been shown inhibit tumor growth ovarian and breast cancers. In this study, we investigated the anti-proliferative of BAY-876 treatment human colorectal (CRC) lines. We metabolic changes on proliferation from HCT116, DLD1, COLO205, LoVo, Caco-2 cells vitro....
Thyroid hormone has been demonstrated to synergize with FSH exert stimulatory effects on the differentiation of porcine granulosa cells. In order further characterize nature thyroid action cells, presence triiodothyronine (T 3 ) receptors in nuclei cells was examined, and qualitatively quantitatively compared during follicular maturation. Then, comparative abilities from varying follicle stages respond T were assessed terms FSH-induced LH/hCG receptor formation progesterone secretion....
Abstract. The facilitative effects of insulin and IGF-I were compared in vitro with regard to induction differentiated functions porcine granulosa cells. monolayers maintained under serum-free conditions the absence or presence FSH (20 μg/l), without graded doses IGF-I. Concurrent treatment produced morphological differentiation augmented LH/hCG receptor binding together an enhancement progesterone estradiol secretion relative alone. alone was incapable exhibiting these effects. Insulin...
Abstract Background Oesophageal squamous cell carcinoma is an aggressive disease owing to early and widespread lymph node metastases. Multimodal therapy radical surgery may improve prognosis. Few studies have investigated the efficacy of thoracic duct resection. Methods Patients with oesophageal who underwent transthoracic minimally invasive oesophagectomy (TMIE) for cancer at Keio University Hospital between January 2004 December 2016 were selected. Between 2008, TMIE was performed in...
Object The incidence of subarachnoid hemorrhage (SAH) in Japan has been reported to be among the highest world. aim this study was analyze SAH and its trends Akita Prefecture, Japan. Methods rate between January 1, 1989, December 31, 1998, investigated using prospective Stroke Register. Computed tomography scans were obtained all suspected cases SAH. During period, 3257 patients with their first registered. crude annual rates men, women, both sexes 20, 33, 27 per 100,000 population year,...
We conducted a population‐based, double‐blind, randomized controlled trial to examine the effect of vitamin C supplementation on serum pepsinogen (PG) level, Helicobacter pylori (H. pylori) infection, and cytotoxin‐associated gene A ( Cag ) status. Subjects aged 40 69 years living in one village Akita prefecture, high‐risk area for gastric cancer Japan, were recruited through annual health check‐up programs. Among 635 subjects diagnosed as having chronic gastritis basis PG levels, after...
Background. To identify differences between the effects of calcitriol and analogue, maxacalcitol, on parathyroid hormone (PTH) bone metabolisms, we conducted a randomized prospective multicentre study patients chronic haemodialysis.