A5081583597- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Lung Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- Cardiac, Anesthesia and Surgical Outcomes
- Dysphagia Assessment and Management
- Tracheal and airway disorders
- Colorectal and Anal Carcinomas
- Inflammatory Biomarkers in Disease Prognosis
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Colorectal Cancer Screening and Detection
- Gastrointestinal disorders and treatments
- Radiation Dose and Imaging
- Frailty in Older Adults
- Immunotherapy and Immune Responses
- Intraperitoneal and Appendiceal Malignancies
- Multiple and Secondary Primary Cancers
Shizuoka Cancer Center
2013-2025
Keio University
2013-2022
Keio University Hospital
2018-2021
Kitasato University
2021
Peking University
2019
Peking University Cancer Hospital
2019
National Cancer Center Hospital East
2016-2019
Abstract This study assessed the impact of postoperative complications on colorectal cancer survival and recurrence after curative surgery using pooled individual patients’ data from three large phase III randomized trials. In total, 5530 patients were included in this study. The classified as those with (C group) without ( NC group). risk factors for overall OS ) disease‐free DFS analyzed. Postoperative found 861 (15.6%) patients. rates at 5 years 68.9% 74.8%, respectively, C group 75.8%...
This study aimed to evaluate the feasibility of and immune response Wilms tumor gene 1 (WT1) peptide-pulsed dendritic cell vaccination combined with gemcitabine (DCGEM) as a first-line therapy among patients advanced pancreatic cancer. Ten HLA-A*2402 were treated WT1 DC (1 × 10(7) cells) on days 8 22 (1000 mg/m(2) ) 1, 15. Induction WT1-specific was evaluated using delayed-type hypersensitivity (DTH) skin test, interferon-γ enzyme-linked immunospot HLA tetramer assays, along assays for...
BACKGROUND: Most previous reports to analyze risk factors for peritoneal recurrence in patients with colon cancer have been observational studies of a population-based cohort. OBJECTIVE: This study aimed determine the stage II III who underwent curative resection. DESIGN: was pooled analysis using combined database obtained from 3 large phase randomized trials (N = 3714). SETTINGS: Individual patient data were collected Japanese Foundation Multidisciplinary Treatment Cancer clinical 7, 15,...
This study aimed to elucidate the residual disease distribution and recurrence patterns in patients with ESCC responding NAC.To appropriately plan a prospective trial for organ preservation approach which includes additional chemoradiotherapy who responded NAC, of needs be elucidated. Given that tumor is located regional field, can safely added eliminate disease.Overall, 483 resectable received NAC followed by transthoracic esophagectomy at 2 high-volume centers were reviewed. The...
Abstract Background Oesophageal squamous cell carcinoma is an aggressive disease owing to early and widespread lymph node metastases. Multimodal therapy radical surgery may improve prognosis. Few studies have investigated the efficacy of thoracic duct resection. Methods Patients with oesophageal who underwent transthoracic minimally invasive oesophagectomy (TMIE) for cancer at Keio University Hospital between January 2004 December 2016 were selected. Between 2008, TMIE was performed in...
New laparoscopic sentinel lymph node navigation using a dedicated magnetic probe and nanoparticle tracer for gastric cancer patients allows minimally invasive surgeries. By identifying the nodes containing nanoparticles, can avoid excessive extraction without nuclear facilities radiation exposure. This paper describes development of probe, ACDC-probe, identification utilizing nonlinear response nanoparticles magnetized by an alternating field with static field. For highly sensitive...
Summary Background The purpose of the current study was to clarify relationship between clinical features dysphagia after esophagectomy and preoperative sarcopenia. Methods A total 187 cases were included in study. psoas cross-sectional area on pre-treatment computed tomography measured thoracic esophageal cancer patients who underwent curative resection. muscle index (PMI) cut-off levels for sarcopenia 6.36 cm2/m2 men 3.92 women. Swallowing function evaluated using videofluoroscopic...
This prospective multicenter non-randomized phase III study aims to evaluate the long-term outcome of sentinel node navigation surgery for early gastric cancer compared with conventional distal or total gastrectomy. Clinically diagnosed primary T1N0M0 patients a single lesion (≤40 mm) and without previous endoscopic treatment will be enrolled in this study. Sentinel nodes are identified by dye radioisotope tracers subjected intraoperative rapid pathology. For negative metastasis,...
Abstract The aim of the present study was to determine whether or not overall survival ( OS ) and disease‐free DFS were affected by tumor location in patients who underwent curative resection for colon cancer a pooled analysis three large phase III studies performed Japan. In total, 4029 included study. Patients classified as having right‐side RC if primary located cecum, ascending colon, hepatic flexure transverse left‐side LCC site within splenic flexure, descending sigmoid recto junction....
Functional dyspepsia (FD) is a gastroduodenal disorder that presents as postprandial fullness, early satiation, or epigastric burning despite no evidence of structural disease. Proton pump inhibitors (PPIs) are often the first choice for treating FD. However, some patients need additional medication because residual symptoms certain level benefit from PPI. For these patients, combination PPI and other agents has possibly more beneficial effect than changing their medication. This study aimed...
Endoscopic resection (ER) has come to be recognized as a standard treatment for early gastric cancer (EGC). While its adoption is expanding, ER remains restricted cases of EGC without lymph node metastasis the local resection. On other hand, histopathological analyses surgically resected specimens have revealed presence (LN) in some mucosal (MGC) and undifferentiated MGC (UD-MGC) considered higher risk nodal metastases than differentiated (D-MGC). To evaluate factors LN MGC, we investigated...