A5036349959- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Cancer Immunotherapy and Biomarkers
- Cutaneous Melanoma Detection and Management
- Gastrointestinal Tumor Research and Treatment
- Esophageal Cancer Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Immunotherapy and Immune Responses
- Sarcoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Tumors and Oncological Cases
- Enhanced Recovery After Surgery
- Congenital Diaphragmatic Hernia Studies
- Colorectal Cancer Treatments and Studies
- Nonmelanoma Skin Cancer Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Colorectal Cancer Surgical Treatments
- Tracheal and airway disorders
- Cancer Diagnosis and Treatment
- Cancer and Skin Lesions
- Melanoma and MAPK Pathways
- Liver Disease Diagnosis and Treatment
Osaka University of Pharmaceutical Sciences
2021-2025
Hiroshima University
2025
National Defense Medical College
2023-2025
Japanese Red Cross Nagoya Daiichi Hospital
2025
Nihon University
2024
Kawasaki Medical School
2010-2024
Waseda University
2024
National Institute of Advanced Industrial Science and Technology
2023
Ryukoku University
2023
Japan Society for the Promotion of Science
2018-2022
To report the clinical features of myasthenia gravis (MG) induced by treatment with immune checkpoint inhibitors using 2-year safety databases based on postmarketing surveys in Japan.We studied 10,277 patients cancer who had received monotherapy either nivolumab or ipilimumab between September 2014 and August 2016. As control group, 105 idiopathic MG were used.There 12 cases (0.12%) among 9,869 been treated nivolumab, but none 408 ipilimumab. These included 6 men women a mean age 73.5 ± 6.3...
Although the most commonly recommended treatment for melanoma and extramammary Paget's disease (EMPD) of genital region is wide surgical excision lesion, procedure highly invasive can lead to functional sexual problems. Alternative treatments have been used local control when was not feasible. Here, we describe four patients with malignancies who were treated boron neutron capture therapy (BNCT).The included one patient vulvar (VM) three EMPD. They underwent BNCT at Kyoto University Research...
Abstract Background To develop and validate a prediction model for severe bronchopulmonary dysplasia (BPD) that integrates the respiratory severity (RS) score with early postnatal risk factors. Methods This retrospective cohort study included preterm infants born at less than 32 weeks gestation or birth weight of 1500 g, from Aichi Prefecture (training dataset) Saitama Medical University (validation April 1, 2016, to March 31, 2020. The primary outcome was BPD, defined as use home oxygen...
Our aim was to assess the long-term clinical outcome of boron neutron capture therapy (BNCT) using 10B-para-boronophenylalanine (BPA) as delivery agent for cutaneous melanoma. Eight patients (eight lesions) were treated between October 2003 and April 2014. Their ages ranged from 48 86 years at time treatment. All targets primary lesions they located on sole or face. No patient had evidence regional lymph node involvement, distant metastases an active secondary cancer. The stage cT1-2N0M0...
Anti-programmed cell death protein 1 (PD-1) antibody monotherapy (PD1) has led to favorable responses in advanced non-acral cutaneous melanoma among Caucasian populations; however, recent studies suggest that this therapy limited efficacy mucosal (MCM). Thus, MCM patients are candidates for PD1 plus anti-cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) combination (PD1 + CTLA4). Data on the of immunotherapy MCM, limited. We aimed compare efficacies and CTLA4 Japanese patients.We...
Laparoscopic liver resection is currently performed in an increasing number of institutions as a minimally invasive treatment. However, no randomized controlled trials have compared laparoscopic and open resections. Twenty-three 24 resections for colorectal cancer metastases (CRCLM) were performed, these data both retrospectively the short-term results. The estimated blood loss was 99 ± 207 mL group 397 381 (P = 0.0018); significantly higher group. There differences surgical procedure, loss,...
Summary Melanoma brain metastasis ( MBM ) is frequent and has a very poor prognosis with no current predictive factors or therapeutic molecular targets. Our study unravels the alterations of cell‐surface glycoprotein CD 44 variants during melanoma progression to . High expression splicing variant 6 44v6) in primary PRM regional lymph node metastases from AJCC Stage IIIC patients significantly predicts development. The 44v6 also enhances migration cells by hyaluronic acid hepatocyte growth...
Extracellular vesicles (EVs) are secretory membrane containing lipids, proteins, and nucleic acids; they function in intercellular transport by delivering their components to recipient cells. EVs observed various body fluids, i.e., blood, saliva, urine, amniotic fluid, ascites. secreted from cancer cells play important roles the formation of environment, including fibrosis, angiogenesis, evasion immune surveillance, even metastasis. However, gastric juice (GJ-EVs) have been largely...
ObjectiveIntracorporeal reconstruction of the digestive tract is technically challenging. The V-Loc 180 wound closure device (Covidien) a self-anchoring unidirectional barbed suture that obviates need for knot tying. aim this prospective cohort study was to investigate use novel in gastrointestinal enterotomy closure.
New laparoscopic sentinel lymph node navigation using a dedicated magnetic probe and nanoparticle tracer for gastric cancer patients allows minimally invasive surgeries. By identifying the nodes containing nanoparticles, can avoid excessive extraction without nuclear facilities radiation exposure. This paper describes development of probe, ACDC-probe, identification utilizing nonlinear response nanoparticles magnetized by an alternating field with static field. For highly sensitive...
To improve the prognosis of clinically resectable type 4 or large 3 gastric cancer (GC), we performed a phase I/II study neoadjuvant-radiotherapy combined with S-1 plus cisplatin. Phase I, standard + dose-escalation design, was to define recommended II dose. Efficacy and safety were evaluated in II. The three dose levels as follows: level 0, 60 mg/m2 on days 1-14 cisplatin day 1; 1, 80 2, 22-35, 1 22. starting 1. Radiotherapy delivered at total 40 Gy fractions for weeks. A six patients...
The impact of interventions based on a biopsychosocial (BPS) model, including components related to sleep and nutrition, pain after total knee arthroplasty (TKA) remains unclear. purpose this study was develop patient education (PE) the BPS model clarify its effects TKA. Participants were 121 patients who had undergone unilateral TKA for osteoarthritis. Patients received usual physiotherapy (control group, n = 71) or plus PE (PE 50) identified. primary outcome change in Knee injury...
This case report describes a 47-year-old premenopausal woman who presented with abdominal discomfort and had been previously monitored for suspected uterine leiomyoma. MRI revealed 15 cm mass within the body slight intratumoural haemorrhage. One month later, patient acute pain was admitted to hospital. Contrast-enhanced CT scans showed significant tumour enlargement 20 cm, disruption along left margin, haemorrhagic ascites, potential dissemination omentum. Total hysterectomy, bilateral...
Preoperative radiotherapy improves local disease control and disease-free survival in patients with advanced rectal cancer; however, a reliable predictive biomarker for the effectiveness of irradiation has yet to be elucidated. Phosphorylation H2A histone family member X (H2AX) γ-H2AX is induced by DNA double-strand breaks associated development colorectal cancer (CRC). The current study aimed clarify relationship between expression CRC radiosensitivity vitro vivo. H2AX levels were analyzed...