A5101912428- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chronic Lymphocytic Leukemia Research
- Hip disorders and treatments
- Monoclonal and Polyclonal Antibodies Research
- IgG4-Related and Inflammatory Diseases
- Renal Diseases and Glomerulopathies
- Bone and Joint Diseases
- Gastric Cancer Management and Outcomes
- Orthopaedic implants and arthroplasty
- Vasculitis and related conditions
- Bone health and treatments
- Lymphoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Neuroendocrine Tumor Research Advances
- Oral Health Pathology and Treatment
- Total Knee Arthroplasty Outcomes
- Sarcoma Diagnosis and Treatment
- Nutrition and Health in Aging
- Tumors and Oncological Cases
- Helicobacter pylori-related gastroenterology studies
- Vascular Malformations and Hemangiomas
- Otitis Media and Relapsing Polychondritis
Niigata University
2016-2025
Kobe Children's Hospital
2003-2024
Institute for Rheumatic Diseases (Japan)
2014-2024
Niigata University Medical and Dental Hospital
2010-2024
Rakuwakai Otowa Hospital
2024
Ulsan National Institute of Science and Technology
2021-2022
Tokyo Denki University
2021-2022
Tokyo Medical and Dental University
2011-2022
Niigata Seiryo University
2022
Fukushima University
2021
Background: Overproduction of interleukin (IL)‐6 may play a pathologic role in rheumatoid arthritis (RA) and chronic periodontitis (CP). The present study assesses IL‐6 receptor (IL‐6R) inhibition therapy on the periodontal condition patients with RA CP. Methods: participants were 28 CP during treatment IL‐6R inhibitor, 27 without inhibitor. Periodontal rheumatologic parameters serum levels cytokine inflammatory markers immunoglobulin G against periodontopathic bacteria examined after...
Background: Tumor necrosis factor (TNF)‐α inhibitor has been shown to affect the periodontal condition of patients with rheumatoid arthritis (RA). The aim present study is assess effect a fully humanized anti‐TNF‐α monoclonal antibody, adalimumab (ADA), on RA and compare serum protein profiles before after ADA therapy. Methods: participants consisted 20 treated ADA. Clinical rheumatologic parameters cytokine levels were evaluated at baseline 3 months later. Serum spot volume was examined...
The manifestations and pathomechanism of postoperative lumbar spinal instability, occurring or progressing secondary to laminectomy, was clarified by means functional radiographic analysis in a series 46 patients over 40 years age. relation between instability the clinical symptoms also is discussed. In under 60 age, at operated level tended appear cases wide laminectomy more often than partial laminectomy. Occurrence progress seems be promoted resection posterior elements rather disc. It...
The accuracy of the urea breath test (UBT) and histological grading for estimation density Helicobacter pylori in gastric mucosa is not known. Real-time (TaqMan) PCR was used to estimate total number H. genomes biopsy samples. These values were compared with those obtained by UBT grade Sydney system. endoscopy antral corporal biopsies performed 88 consecutive untreated patients dyspepsia. Bacterial culture rapid urease done fresh materials. TaqMan examination on serial paraffin sections Of...
Haploinsufficiency of A20 (HA20) is caused by loss-of-function TNFAIP3 variants. Phenotypic and genetic features HA20 remain uncertain; therefore, the clinical distinction between Behçet's disease (BD) requires clarification.We have collected 12 Japanese BD-like families. Probands these families were analyzed whole exome sequencing (WES) subsequent Sanger sequencing. Clinical compared 54 patients (including previously reported new cases) 520 BD patients.We identified c.1434C>A:p.(Cys478*) in...
Abstract Objectives To efficiently detect somatic UBA1 variants and establish a clinical scoring system predicting patients with pathogenic in VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome. Methods Eighty-nine Japanese clinically suspected syndrome were recruited [81 males 8 females; median age of onset 69.3 years (interquartile range 62.1–77.6)]. Peptide nucleic acid–clamping PCR (PNA-PCR), regular targeting exon 3 clustering subsequent Sanger sequencing...
Spinal hypertrophic pachymeningitis (HP) is an extremely rare disorder characterized by the thickening of spinal dura mater, which harbors distinct repertoires immune cells due to unique partitioning arachnoid blood-CSF barrier. The objectives were identify pathogenesis and therapeutic strategies for HP. This retrospective cohort study analyzed clinical pathologic profiles patients with idiopathic/immune-mediated HP including Among 61 HP, all 6 Japanese a median observation period 88.8...
Abstract Interleukin‐6 (IL‐6) may play a pathological role in rheumatoid arthritis (RA) and periodontitis. Although the efficacy of medication with IL‐6 receptor inhibitor, tocilizumab (TCZ), has been demonstrated treatment RA, very little is known about whether TCZ therapy affects The aim present study to compare periodontal condition patients RA periodontitis before after therapy. participants consisted 20 who were treated 40 received tumor necrosis factor inhibitor (TNFI). Clinical...
HLA-DRB1 alleles are major determinants of genetic predisposition to rheumatic diseases. We assessed whether DRB1 associated with susceptibility particular clinical features adult onset Still's disease (AOSD) in a Japanese population by determining the allele distributions.DRB1 genotyping 96 patients AOSD and 1,026 healthy controls was performed. Genomic DNA samples from were also genotyped for MEFV exons 1, 2, 3, 10 direct sequencing.In AOSD, we observed predisposing association DRB1*15:01...
Abstract Hepcidin, a major regulator of iron metabolism and homeostasis, is regulated by inflammation. Recent studies have suggested that hepcidin are involved in osteoporosis, the aim this study was to determine whether serum levels correlated with degree osteoporosis patients rheumatoid arthritis (RA). A total 262 RA (67.5 ± 11.4 years; 77.5% female) were enrolled. Serum iron, ferritin, positively each other. Multiple regression analyses revealed level femoral T Z scores, whereas not....
Nitric oxide (NO) relaxes the internal anal sphincter (IAS), but its enzymatic source(s) remains unknown; neuronal (nNOS) and endothelial (eNOS) NO synthase (NOS) isoforms could be involved. Also, interstitial cells of Cajal (ICC) may involved in IAS relaxation. We studied relative roles nNOS, eNOS, c-Kit-expressing ICC for relaxation using genetic murine models. The basal tone rectoanal inhibitory reflex (RAIR) were assessed vivo by a purpose-built solid-state manometric probe wild-type,...
Objective To analyze the neuropathic pain (NeP) components in patients with rheumatoid arthritis (RA).
A timely diagnosis of developmental dysplasia the hip (DDH) is important for satisfactory clinical outcomes. Ultrasonography a useful tool DDH screening; however, it technically demanding. We hypothesized that deep learning could assist in DDH. In this study, several deep-learning models were assessed to diagnose on ultrasonograms. This study aimed evaluate accuracy diagnoses made by artificial intelligence (AI) using ultrasound images DDH.Infants who up 6 months old with suspected included....
It has already been more than 50 years since the Pavlik harness was introduced in Japan, and today is widely recognized as standard initial treatment modality for developmental dysplasia of hip. We performed a multicenter nationwide questionnaire study concerning results twice 1994 2008.In 2008, we sent questionnaires to 12 institutes Japan specializing mainly pediatric orthopedics. compare these two studies discuss differences reduction rates, incidence avascular necrosis femoral epiphysis...
Objective. Reactive amyloid A (AA) amyloidosis is a serious and life-threatening systemic complication of rheumatoid arthritis (RA). We evaluated the safety therapy with anti-tumor necrosis factor anti-interleukin 6 biologic agents in RA patients reactive AA amyloidosis, together prognosis hemodialysis (HD)-free survival, comparison without such therapy. Methods. One hundred thirty-three an established diagnosis participated study. Clinical data were assessed from patient records at time...
The objective of this study is to compare the clinical and laboratory features Japanese patients with IgG4-related disease, without allergic conditions.We retrospectively examined courses 51 definitively diagnosed IgG4-RD, collected from Nagaoka Red Cross Hospital between January 2004 August 2017, reference presence conditions.Among these patients, 43% had conditions. In allergy group, proportion females was significantly higher, age at diagnosis lower, upper body organ involvement...
Multiple sclerosis is a relatively rare disease, and complications of multiple rheumatoid arthritis are much rarer. Since anti-tumor necrosis factor therapy increases exacerbations sclerosis, demyelinating diseases contraindicate therapy. There have been few reports anti-interleukin-6 receptor for patients with complicated sclerosis. A 53-year-old Japanese woman was admitted to our hospital because her uncontrolled oral methotrexate, tacrolimus, prednisolone. She had developed when she 25...
Objectives To determine whether serum immunity to Porphyromonas gingivalis peptidylarginine deiminase (PPAD) affects the clinical response biological disease-modifying antirheumatic drug (bDMARD) in patients with rheumatoid arthritis (RA). Methods In a retrospective study, rheumatologic and periodontal conditions of 60 RA who had been treated conventional synthetic DMARD were evaluated before (baseline) after 3 6 months bDMARD therapy. After levels anti-PPAD immunoglobulin G (IgG) determined...
Abstract Background Empirical data have suggested that mind-body practices originated in Eastern traditions can cause desirable changes to psychological traits, the brain, somatic physiological functions, etc. Martial arts Japan refer physical/mental were developed based on historical combat techniques. Today, martial are considered activities seek embodiment and/or unity, as well sports. studies involving practitioners of Japanese date remain scarce. Methods We conducted a questionnaire...
Background Little is known about the relationship between disease activity of Behçet (BD) and incidence inflammatory major organ events. Objectives In this prospective registry study, we investigated association Disease Current Activity Form (BDCAF) events, defined as inflammation ocular, central nervous, intestinal, vascular systems in BD. Methods We enrolled participants from Japanese multicenter cohorts. The BDCAF was evaluated annually. BD-related symptoms, including were monitored....
Abstract Objective We aimed to gather real-world clinical evidence of detailed disease activity, treatments, remission rates, and adverse events (AEs) associated with vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome in a prospective study. Methods Patients Japan suspected having VEXAS were enrolled registry A novel activity measure (VEXASCAF) assessing 11 symptoms was evaluated at enrolment after 3 months. AEs, survival, CRP levels, treatments also recorded months...