A5034618931- Systemic Lupus Erythematosus Research
- Ocular Diseases and Behçet’s Syndrome
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Rheumatoid Arthritis Research and Therapies
- Retinal and Optic Conditions
- Immune Cell Function and Interaction
- Peripheral Neuropathies and Disorders
- Vasculitis and related conditions
- Autoimmune and Inflammatory Disorders Research
- Cerebral Venous Sinus Thrombosis
- Systemic Sclerosis and Related Diseases
- Immunotherapy and Immune Responses
- Atherosclerosis and Cardiovascular Diseases
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Multiple Sclerosis Research Studies
- Infectious Diseases and Tuberculosis
- Chemokine receptors and signaling
- Immunodeficiency and Autoimmune Disorders
- Musculoskeletal synovial abnormalities and treatments
- Inflammatory Myopathies and Dermatomyositis
- Cytomegalovirus and herpesvirus research
- Autoimmune Neurological Disorders and Treatments
Kitasato University
2016-2025
Nobuhara Hospital
2018-2025
Teikyo University
2005-2024
Leiden University Medical Center
2023
Ebara Hospital
2018
Mitsubishi Group (Japan)
2016
University Hospital Complex Of Vigo
2016
Complexo Hospitalario Universitario A Coruña
2016
National Sagamihara Hospital
2011
Toho University
2011
Paired serum and cerebrospinal fluid (CSF) specimens from 14 patients with systemic lupus erythematosus (SLE) central nervous system (CNS) involvement were studied for interleukin-6 (IL-6) activity using the IL-6-dependent murine hybridoma, MH60.BSF2. We also 23 noninflammatory neurologic diseases, 9 SLE without CNS involvement. CSF IL-6 was elevated only in involvement, although there no significant difference among 3 groups. not correlated either CSF-serum albumin quotient (Q albumin; an...
Recent studies have disclosed variable effects of IL-10 on viabilities human B lineage cells. Thus, has been shown to prevent apoptosis germinal center cells, whereas found induce B-chronic lymphocytic leukemia suggesting the possibility that might be different depending state activation The current therefore examined in detail regulation survival peripheral blood cells by and its relevance Ig production. Highly purified from healthy adult individuals were cultured with Staphylococcus aureus...
Abstract Objective To explore the association of antibodies directed against N ‐methyl‐ D ‐aspartate receptor subunit NR2 (anti‐NR2) in cerebrospinal fluid (CSF) with neuropsychiatric manifestations systemic lupus erythematosus (NPSLE). Methods Paired serum and CSF specimens were obtained from 56 patients NPSLE (38 diffuse psychiatric/neuropsychological syndromes [diffuse NPSLE] 18 neurologic or peripheral neuropathy [focal NPSLE]) 20 control noninflammatory diseases. IgG anti‐NR2 measured...
Abstract Objective. Since the level of interferon‐α (IFNα) is increased in sera patients with active systemic lupus erythematosus (SLE) and detectable cerebrospinal fluid (CSF) some SLE neuropsychiatric manifestations, we investigated contribution IFNα to pathogenesis manifestations SLE. Methods. levels were quantitated by radioimmunoassay CSF serum samples from 17 28 alone or other neurologic disorders. Results. Levels 5 6 psychosis, 4 these patients, higher than those serum. decreased when...
The aim of this study was to elucidate the characteristics, pathogenesis and treatment strategy hypertrophic pachymeningitis that is associated with myeloperoxidase anti-neutrophil cytoplasmic antibody (ANCA). We retrospectively investigated clinical, radiological, immunological pathological profiles 36 patients immune-mediated or idiopathic pachymeningitis, including 17 myeloperoxidase-ANCA, four proteinase 3-ANCA, six other disorders, nine 'idiopathic' variety....
Behçet disease (BD) is a multisystem associated with poor prognosis in cases of gastrointestinal, neurological, or vascular involvement. We conducted multicenter, prospective, open-label, single-arm phase 3 study to determine the efficacy, safety, and pharmacokinetics infliximab (IFX) BD patients these serious complications who had displayed response intolerance conventional therapy. IFX at 5 mg/kg was administered 18 (11 intestinal BD, neurological [NBD], 4 [VBD]) weeks 0, 2, 6 every 8...
To determine whether the intrathecal concentrations of cytokines/chemokines are associated with, or influenced by, serum in patients with central neuropsychiatric systemic lupus erythematosus (NPSLE), and to ascertain increased production intrathecally relative levels is presence NPSLE.52 SLE (30 NPSLE 22 non-NPSLE), for whom CSF samples were obtained at same time, enrolled. 27 kinds cytokine/chemokine other than IFN-α cerebrospinal fluid (CSF) measured by Bio-Plex Pro Assays. concentration...
Abstract Introduction Although neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the recalcitrant complications disease, its pathogenesis still remains unclear. Previous studies revealed that antibodies reactive with NMDA (N-methyl-D-aspartate) receptor NR2 (anti-NR2) are elevated in cerebrospinal fluid (CSF) patients diffuse psychiatric/neuropsychological syndromes (diffuse NPSLE), which usually more than neurologic NPSLE (focal NPSLE). Two mechanisms have been implicated for...
The capacity of mAb directed at the CD3 molecular complex (64.1) to induce T cell-dependent B cell proliferation and differentiation was examined. Coculture cells with mitomycin C-treated T4 (T4 mito) stimulated by immobilized 64.1 resulted in marked Ig-secreting (ISC) generation absence any additional stimulation. magnitude responses induced 64.1-stimulated mito far greater than that other stimuli, such as Staphylococcus aureus plus factors produced mitogen-activated cells, PWM, or soluble...
Objective To compare the role of antibodies against ribosomal P protein (anti-P) with that neuronal cells (anti-N) in pathogenesis central nervous system (CNS) involvement systemic lupus erythematosus (SLE). Methods Sera from 87 SLE patients (27 non-CNS SLE, 34 psychosis, and 26 nonpsychotic CNS lupus) 20 control neurologic manifestations without cerebrospinal fluid (CSF) 41 were assayed for IgG anti-P anti-N by an enzyme-linked immunosorbent assay (ELISA) using synthetic peptides a cell...
Objective. To survey and elucidate the clinical characteristics of CMV infection in rheumatic disease patients.
To investigate the possibility that IgG anti-NR2 glutamate receptor antibodies (anti-NR2) derived from patients with systemic lupus erythematosus (SLE) cause an immunologic interaction endothelial cells (ECs) in blood-brain barrier, resulting inflammation of allowing entrance these autoantibodies into cerebrospinal fluid.Purified 14 SLE were tested for their ability to bind double-stranded DNA (dsDNA) and ECs, modulate adhesion molecule expression cytokine production by activate NF-κB...
Abstract Objective . Although it has been reported that anti–ribosomal P protein antibodies (anti‐P) are highly specific for lupus psychosis, there have discrepancies among the studies regarding clinical correlation of these with systemic erythematosus (SLE). The present study was therefore carried out to reappraise association anti‐P and neuropsychiatric SLE. Methods Highly purified synthetic ribosomal peptides carboxyl‐terminal 22‐amino acid sequence were conjugated human serum albumin...
To determine levels of the soluble form chemokine fractalkine (sFkn) and its receptor, CX(3)CR1, in patients with systemic lupus erythematosus (SLE) neuropsychiatric involvement (NPSLE) SLE without involvement, to assess their relationship disease activity organ damage.Levels sFkn serum cerebrospinal fluid (CSF) were measured by enzyme-linked immunosorbent assay. Expression Fkn CX(3)CR1 was quantified using real-time polymerase chain reaction. Surface expression on peripheral blood...
We explored the relationship of antibodies to whole ribosomal P proteins (P0, P1, and P2) in cerebrospinal fluid (CSF) with diffuse psychiatric/neuropsychological syndromes systemic lupus erythematosus (SLE). CSF samples were obtained from 71 SLE patients (52 [diffuse NP-SLE] 19 neurological or peripheral neuropathy [focal NP-SLE]) as well 24 non-inflammatory disease. Immunoglobulin G (IgG) C-terminal 22-amino acid synthetic peptide (anti-PC22) those purified bovine (anti-whole P) determined...
To delineate the clinical characteristics of neuro-Behçet's disease (NBD), a multicenter retrospective survey was performed in BD patients who had presented any neurological manifestations between 1988 and 2008. The diagnosis acute NBD, chronic progressive (CP) non-NBD confirmed by review records. Data on total 144 were collected; 76 with 35 CP 33 non-NBD. High-intensity lesions T2-weighted magnetic resonance imaging (MRI) found 60.5% 54.2% 42.4% non-NBD, whereas brainstem atrophy observed...