A5101578858- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- ECG Monitoring and Analysis
- Cardiac pacing and defibrillation studies
- Heart Rate Variability and Autonomic Control
- Fatigue and fracture mechanics
- Synthesis and Reactivity of Heterocycles
- Numerical methods in engineering
- Synthesis and pharmacology of benzodiazepine derivatives
- Radiopharmaceutical Chemistry and Applications
- Fuel Cells and Related Materials
- Structural Load-Bearing Analysis
- Hemoglobin structure and function
- High-Velocity Impact and Material Behavior
- Neurological disorders and treatments
- Cardiac Arrest and Resuscitation
- Cardiovascular Function and Risk Factors
- Synthesis and Characterization of Pyrroles
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Imaging and Diagnostics
- Ion channel regulation and function
- Inhalation and Respiratory Drug Delivery
- Medical Imaging Techniques and Applications
- Sarcoidosis and Beryllium Toxicity Research
National Defense Medical College
1997-2025
GlaxoSmithKline (Japan)
2018-2024
The University of Tokyo
2023
National Defense Medical College Hospital
2016-2023
National Institutes for Quantum Science and Technology
2017-2019
Gifu University
2015-2019
Hashimoto Municipal Hospital
2019
Gifu University Hospital
2017
Nihon University
2004-2016
Toyota Technological Institute
2016
Abstract Objectives To efficiently detect somatic UBA1 variants and establish a clinical scoring system predicting patients with pathogenic in VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome. Methods Eighty-nine Japanese clinically suspected syndrome were recruited [81 males 8 females; median age of onset 69.3 years (interquartile range 62.1–77.6)]. Peptide nucleic acid–clamping PCR (PNA-PCR), regular targeting exon 3 clustering subsequent Sanger sequencing...
Intratumoral hemorrhage occurs frequently in pituitary macroadenoma and manifests as apoplexy recent or old silent hemorrhage. T2*-weighted gradient-echo (GE) MR imaging is the most sensitive sequence for detection of acute intracranial GE was used to investigate intratumoral macroadenomas.Twenty-five consecutive patients who underwent total subtotal resection with heights from 17 53 mm, including 1 patient classic apoplexy, before surgery, imaging. For histologic assessment whole surgical...
Aims Only a few families with neuronal differentiation 1 (NEUROD1)-deficient diabetes, currently designated as maturity-onset diabetes of the young 6 (MODY6), have been reported, but mostly in Caucasian, and no mutation has identified by family-based screening Japanese. Accordingly, phenotypic details disease remain to be elucidated. Methods We examined total 275 subjects having suspected MODY who were negative for mutations MODY1-5 referred from 155 medical institutions throughout Japan. So...
B-cell lymphomas are neoplastic diseases occasionally associated with chronic inflammation. mRNA vaccines for coronavirus disease 2019 (COVID-19) induce inflammatory responses, which often lead to fever and lymphadenopathies indistinguishable from lymphomas. Although both can be influential, the correlation between them is unclear. Herein, we present first case of marginal zone lymphoma following COVID-19 vaccination. An 80-year-old Japanese woman presented a right temporal mass that...
Recently, some clinicians have been diagnosing and treating arrhythmias on the basis of electrocardiogram (ECG) devices with low accuracy. In Europe US, several statements use ECGs already published by related academic societies. addition, relaxation regulations media advertising ambulatory/wearable ECG devices, frequency simple general public will increase in future. Therefore, this statement describes functions features non-invasive ambulatory or wearable that approved as medical Japan...
ABSTRACT Introduction Interstitial cystitis with Hunner lesion (IC/HL) is an enigmatic, chronic inflammatory disease of the urinary bladder. Few documented cases have reported IC/HL involving upper tract. Case Presentation A 51‐year‐old Japanese woman developed bilateral ureteral stenosis and associated hydronephrosis, resulting in increased serum creatinine concentrations. Cystography showed no evidence vesicoureteral reflux or bladder deformity. Ureteroscopy severe due to mucosal...
Background: The noninvasive methods for predicting a successful pulmonary vein isolation (PVI) have not been well described. aim of this study was to assess the usefulness P‐wave signal‐averaged electrocardiogram (P‐SAECG) in chance PVI patients with atrial fibrillation (AF). Methods: A P‐SAECG recorded before (pre), 1 day after, and 3–4 months after 51 AF (41, paroxysmal AF; 10, persistent AF). Three‐dimensional electroanatomic mapping (3D‐EAM) right left atria PVs performed 10 analyze...
Diabet. Med. 27, 1430–1435 (2010) Abstract Aims The study aimed to investigate early‐stage atherosclerosis in patients with impaired fasting glucose compared tolerance. Methods Body mass index, systolic blood pressure, plasma glucose, lipid variables, ankle–brachial pressure index and brachial–ankle pulse wave velocity were measured 2842 subjects from Takasaki city located approximately 100 km north of Tokyo Japan. divided into the following five groups based on a 75‐g oral tolerance test:...
Increasing evidence provides a clear association between rapid eye movement sleep behavior disorders (RBD) and Parkinson's disease (PD), but the clinical features that determine co-morbidity of RBD PD are not yet fully understood.We evaluated characteristics nocturnal disturbances other motor non-motor related to in patients with impact on their quality life. Probable (pRBD) was using Japanese version screening questionnaire (RBDSQ-J).A significantly higher frequency pRBD observed than...
Purpose: The Informing the Pathway of COPD Treatment (IMPACT) study demonstrated that single-inhaler triple therapy fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) reduces moderate/severe exacerbation rates and improves lung function health status versus FF/VI or UMEC/VI dual in patients with symptomatic a history exacerbations. This analysis evaluated efficacy safety FF/UMEC/VI enrolled Japan. Patients methods: IMPACT was 52-week, randomized, double-blind, multicenter comparing...
Noninvasive electrocardiographic (ECG) markers are promising arrhythmic risk stratification tools for identifying sudden cardiac death. However, little is known about the usefulness of noninvasive ECG derived from ambulatory ECGs (AECG) in patients with previous myocardial infarction (pMI). We aimed to determine whether AECG can predict serious events pMI.We prospectively analyzed 104 pMI (88 males, age 66 ± 11 years), evaluating late potentials (LPs), heart rate turbulence, and nonsustained...
Background There is evidence that some patients with Brugada syndrome (BS) exhibit atrial tachyarrhythmias including paroxysmal fibrillation. We investigated whether BS associated not only vulnerability to ventricular fibrillation, but also Methods and Results In 15 Brugada-type electrocardiogram (ECG) (14 men, 1 woman; age 52.8±12.9 years) age-matched control (12 3 women; 50.9±18.9 years), the P-wave signal-averaged ECG was recorded, filtered duration derived from vector magnitude obtained...
Hyperglycemic chorea-ballism is predominantly observed in older type 2 diabetic patients, and it rare 1 diabetes ketoacidosis (DKA). Huntington's disease (HD) one of several genetic syndromes associated with diabetes, although the reported prevalence association varies. There are few opportunities for most physicians to diagnose early-stage HD.We describe bilateral hyperglycemic a 40-yr-old female patient DKA HD.The study was conducted tertiary care referral hospital.On admission, exhibited...
Abstract Background Fluticasone propionate 50 μg/salmeterol xinafoate 25 μg (FP/SAL) is widely used in adults and children with asthma, but there sparse information on its use very young children. Methods This was a randomized, double‐blind, multicentre, controlled trial conducted aged 8 months to 4 years. During 2‐week run‐in period, they all received FP twice daily. At randomization, commenced FP/SAL or daily for weeks. All were then given only, 16‐week open‐label study continuation....
Key Clinical Message In a patient with anti‐aminoacyl tRNA synthetase antibody and anti‐OJ syndrome, interventions likes warming, prostaglandins, antiplatelets failed. However, prednisolone pulse treatment rapidly halted disease progression. Patients mild interstitial pneumonia, myositis, extremity necrosis should be promptly considered for anti‐synthetase syndrome receive immunosuppression after ruling out other causes. Abstract Anti‐aminoacyl (ARS) autoantibodies are myositis‐specific,...
Diesel exhaust (DE) is a major air pollutant in urban areas. To clarify the effects of DE on exacerbation asthma, guinea pigs were exposed 12 h daily to 3 mg/m(3) or for 8 wk with without sensitization ovalbumin (OVA). In DE-exposed sensitized animals, both immediate (IAR) and late (LAR) airway responses enhanced after inhalation challenge by OVA, compared DE-unexposed animals. Mucus was greatly accumulated airways animals during IAR. The number eosinophils level sialic acid concentration...
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), which is a ligand-dependent transcriptional factor, forms heterodimer with retinoid X receptor (RXR) and controls many genes that are relevant to the regulation of lipid metabolism insulin sensitization. Recent studies have shown stimulation PPAR-gamma inhibits production inflammatory cytokines in monocytes macrophages. Alcohol lipopolysaccharide (LPS) already been induce liver injury through activation cytokines. Thus, by its...
We have developed hemoglobin vesicles (HbVs) as a substitute for red blood cells (RBCs). investigated the efficacy of HbV transfusion in treatment massive hemorrhage rabbits setting thrombocytopenic coagulopathy, focusing on hemostasis by subsequent platelet transfusion.Thrombocytopenic coagulopathy was induced repeated withdrawal and isovolemic retransfusion autologous RBC (platelet counts <45,000/μL). A penetrating liver injury then made. For 30 min, bleeding volume measured every 10 after...
Introduction: Dual AV nodal physiology is the electrophysiologic substrate for reentrant tachycardia (AVNRT), but anatomic basis this arrhythmia remains to be elucidated. Atrial flutter (AFL) has been shown more frequently inducible in patients with AVNRT. Methods and Results: A 3.2‐French, 20‐MHz intracardiac ultrasound (ICUS) catheter was introduced into coronary sinus (CS), two‐dimensional ICUS images were recorded during transducer pullback 21 AVNRT 18 control patients. Three‐dimensional...