A5067364385- Lung Cancer Diagnosis and Treatment
- Innovations in Medical Education
- Cancer Diagnosis and Treatment
- Clay minerals and soil interactions
- Medical Imaging and Pathology Studies
- Reproductive Biology and Fertility
- Tracheal and airway disorders
- Acute Myeloid Leukemia Research
- Diabetes Management and Education
- Metastasis and carcinoma case studies
- Pleural and Pulmonary Diseases
- Interprofessional Education and Collaboration
- Lung Cancer Treatments and Mutations
- Effects and risks of endocrine disrupting chemicals
- Hypothalamic control of reproductive hormones
- Airway Management and Intubation Techniques
- Platelet Disorders and Treatments
- Aquaculture disease management and microbiota
- Growth Hormone and Insulin-like Growth Factors
- Aquaculture Nutrition and Growth
- Cancer, Hypoxia, and Metabolism
- DNA Repair Mechanisms
- Ovarian function and disorders
- Empathy and Medical Education
- Transplantation: Methods and Outcomes
Nagoya University
2013-2024
Showa University
2024
Nagoya University Hospital
2021-2023
Saku Central Hospital
2023
Muroran Institute of Technology
2014-2023
Tohoku University Hospital
2019-2022
Tokyo Medical and Dental University
2022
Aichi Medical University
2022
Gunma University
2011-2020
Musashi University
2020
Melatonin (N-acetyl-5-methoxytryptamine) is an indoleamine originally identified in the pineal gland, where it synthesised enzymatically from serotonin (5-hydroxytryptamine) by sequential action of arylalkylamine N-acetyltransferase (AANAT) and acetylserotonin O-methyltransferase (ASMT; also known as hydroxyindole O-methyltransferase). directly affects ovarian functions previous studies have suggested that melatonin ovary. In present study, we examined whether AANAT ASMT are expressed adult...
Regnase-1 (also known as Zc3h12a or MCPIP-1) is an endoribonuclease involved in mRNA degradation of inflammation-associated genes. inactivated response to external stimuli through post-translational modifications including phosphorylation, yet the precise role phosphorylation remains unknown. Here, we demonstrate that interleukin (IL)-17 induces Act1-TBK1/IKKi–dependent manner, especially nonhematopoietic cells. Phosphorylated released from endoplasmic reticulum (ER) into cytosol, thereby...
Abstract Objectives To efficiently detect somatic UBA1 variants and establish a clinical scoring system predicting patients with pathogenic in VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome. Methods Eighty-nine Japanese clinically suspected syndrome were recruited [81 males 8 females; median age of onset 69.3 years (interquartile range 62.1–77.6)]. Peptide nucleic acid–clamping PCR (PNA-PCR), regular targeting exon 3 clustering subsequent Sanger sequencing...
A chest tube is usually placed in the pleural cavity after wedge resection of lung, even thoracoscopic procedures. The aim this study was to determine validity and safety postoperative management without placement for patients undergoing lung.Between 1998 2002, 93 underwent lung. In January 2000, we established following criteria avoiding placement: (1) absence air leaks during intraoperative alternative sealing test, (2) bullous or emphysematous changes on inspection, (3) severe adhesions,...
T-helper cell type 1 (Th1) polarization in chronic immune thrombocytopenia (cITP) has been reported at the protein and mRNA levels. We evaluated impact of Th1/Th2 cytokine receptor functional polymorphisms on both susceptibility to, severity of, cITP. analysed IFN-γ + 874 T/A, IFN-γR -611G/A, IL-4 -590C/T, IL-4Rα Q576R 126 cITP patients (male/female: 34/92; median age: 47.7 years) 202 healthy control donors. Genotyping was determined by PCR direct sequencing. The ratio detected peripheral...
Dasatinib, an oral inhibitor of ABL and SRC family tyrosine kinases, is effective drug for patients with Philadelphia chromosome positive (Ph+) leukemia, especially those who develop resista...
The feasibility of systematic node dissection (SND) for stage I primary lung cancer by video-assisted thoracic surgery (VATS) remains controversial. aim this study was to assess the SND VATS.Four hundred and eleven patients with clinical were enrolled in study. Two twenty-one patients, VATS group, underwent a major pulmonary resection through minithoracotomy (30-70mm) two access ports; 190 open thoracotomy (OT) did so anterolateral thoracotomy. groups compared regarding data including number...
The effects of treatment with pitavastatin on inflammatory and platelet activation markers adiponectin in 117 patients hyperlipidemia were investigated to determine whether may prevent the progression atherosclerotic changes hyperlipidemic patients. Adiponectin levels prior without diabetes lower than normolipidemic controls. Both total cholesterol low-density lipoprotein decreased significantly after administration. Additionally, or type 2 exhibited a significant increase 6 months...
Abstract Aim: Taxanes are regarded as key chemotherapy agents for breast cancer and gynecologic malignancies; therefore the ovarian toxicity of paclitaxel (PTX) is a matter importance to younger women with malignancies. We examined PTX its influence on fertility in rats. Methods: Female Wistar rats aged 6–8 weeks received five doses at 3‐day intervals. Ovarian was assessed by counting follicles, corpora lutea atretic well detecting apoptosis measuring serum levels estradiol (E2) progesterone...
The purpose of the present study was to investigate an association between serum cholesterol levels and depressive state.Physical examinations mental assessments were performed for 13702 human dock visitors. We obtained 13571 sets complete data total cholesterol, scores state possible confounders such as sex, age, body weight, mass index (BMI), recent weight loss, protein concomitant medical diagnoses.Their varied significantly across after adjusting age gender. After controlling all above...
A prolactin cDNA was cloned from a expression library constructed total RNA of bullfrog (Rana catesbeiana) adenohypophyses by immunoscreening with antiserum against prolactin. The clone thus obtained contained 249 bp insert. Using this as probe, plaque hybridizations were performed and two additional clones obtained. These had polyadenylation site different that the first clone, suggesting 3'-untranslated sequence heterogeneous in length. longest 830 bp, which encoded part signal peptide...
Most of the previous studies on ovarian hyaluronan (HA) have focused mature antral follicles or corpora lutea, but scarcely small preantral follicles. Moreover, origin follicular HA is unknown. To clarify localization and its synthases in growing follicles, involvement follicle growth, gonadotropin regulation synthase ( Has ) gene expression, this study, perinatal, immature, adult ovaries Wistar-Imamichi rats were examined histologically biochemically by vitro culture. was detected...