A5023317309- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Fibroblast Growth Factor Research
- Platelet Disorders and Treatments
- Cancer therapeutics and mechanisms
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Advanced Sensor and Energy Harvesting Materials
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Neurogenesis and neuroplasticity mechanisms
- Immunodeficiency and Autoimmune Disorders
- Receptor Mechanisms and Signaling
- Blood groups and transfusion
- Tactile and Sensory Interactions
- Urticaria and Related Conditions
- Glycosylation and Glycoproteins Research
- Computational Drug Discovery Methods
- Genomics, phytochemicals, and oxidative stress
- Hereditary Neurological Disorders
- Immune cells in cancer
- Protein Kinase Regulation and GTPase Signaling
- Kruppel-like factors research
Hyogo University
2022-2025
Hyogo Medical University
2017-2021
Gunma University
2014-2020
Keio University
2003-2011
Pericytes (PCs) are vascular mural cells embedded in the basement membrane of micro blood vessels. It has been proposed using a C.B-17 mouse model stroke that normal brain PCs converted to ischemic (iPCs), some which express various stem cell markers. We previously reported nuclear factor erythroid-2-related 2 (Nrf2) protected against oxidative stress following ischemia and promoted PC reprogramming process. The present study examined molecular mechanisms underlying induction Nrf2. revealed...
T-helper cell type 1 (Th1) polarization in chronic immune thrombocytopenia (cITP) has been reported at the protein and mRNA levels. We evaluated impact of Th1/Th2 cytokine receptor functional polymorphisms on both susceptibility to, severity of, cITP. analysed IFN-γ + 874 T/A, IFN-γR -611G/A, IL-4 -590C/T, IL-4Rα Q576R 126 cITP patients (male/female: 34/92; median age: 47.7 years) 202 healthy control donors. Genotyping was determined by PCR direct sequencing. The ratio detected peripheral...
Predictions of interactions between target proteins and potential leads are great benefit in the drug discovery process. We present a comprehensively applicable statistical prediction method for any chemical compounds, which requires only protein sequence data structure utilizes learning support vector machines. In order to realize reasonable comprehensive predictions can involve many false positives, we propose two approaches reduction positives: (i) efficient use multiple models framework...
Immense previous efforts have elucidated the core machinery in cell migration, actin remodeling regulated by Rho family small GTPases including RhoA, Cdc42, and Rac1; however, spatiotemporal regulation of these molecules remains largely unknown. Here, we report that EGF induces biphasic Rac1 activation process UTKO1, a migration inhibitor, inhibits second EGF-induced wave but not first wave. To address mechanism role activation, identified 14-3-3ζ as target protein UTKO1 also showed...
Programmed death-1 (PD-1, PDCD1) and cytotoxic T lymphocyte-associated antigen-4 (CTLA-4, CTLA4) play central roles in immune checkpoint pathways. Single nucleotide polymorphisms (SNPs) of PDCD1 CTLA4 have been reported to be associated with susceptibility some autoimmune diseases. However, the potential association between SNPs these genes risk chronic thrombocytopenia (cITP) remain controversial obscure. The aims this study were clarify influence on developing cITP its clinical features....
Abstract Single nucleotide polymorphisms (SNPs) in interleukin 17 ( IL17A ) and IL‐23 receptor IL23R are involved the pathogenesis of many cancers autoimmune diseases. We investigated influence SNPs on risk developing multiple myeloma (MM) its clinical features. obtained genomic DNA from 120 patients with MM 201 healthy controls detected −197 G/A (rs2275913) H3Q (rs1884444) genotypes using polymerase chain reaction‐restriction fragment length polymorphism method. There were no significant...
We previously demonstrated that neural stem/progenitor cells (NSPCs) were induced within and around the ischemic areas in a mouse model of stroke. These injury/ischemia-induced NSPCs (iNSPCs) differentiated to electrophysiologically functional neurons vitro, indicating presence self-repair system following injury. However, during healing process after stroke, gradually occupied by inflammatory cells, mainly microglial cells/macrophages (MGs/MΦs), neurogenesis rarely occurred areas....
Pacinian corpuscles are vibration-sensing mechanoreceptors that densely distributed in the dermis of human hand. Although they also known to occur various other regions/structures throughout body, including adventitia large vessels, their precise distribution and function arteries remain unclear. In present study, we identified Pacini-like lamellar (LCs) adjacent femoral artery, investigated with respect structure via a histological analysis. We nine LCs were localized connective tissue...
Polymorphisms of the interleukin-10 (IL-10) gene, which alter production IL-10, have been implicated in many cancers. We investigated association between gene polymorphisms promoter region IL-10 (-1082 G/A, IL-10-819 C/T, and -592 C/A) risk to develop myelodysplastic syndrome (MDS) clinical features MDS. Genomic DNA was extracted from 119 patients with MDS or chronic myelomonocytic leukemia 202 healthy controls. Genotypes were determined by PCR-restriction fragment length polymorphism. There...
Stem cell therapy is used to restore neurological function in stroke patients. We have previously reported that ischemia-induced multipotent stem cells (iSCs), which are likely derived from brain pericytes, develop poststroke human and mouse brains. Although we demonstrated iSCs can differentiate into neural lineage cells, the factors responsible for inducing this differentiation remain unclear. In study, found LDN193189, a bone morphogenetic protein (BMP) inhibitor, caused irreversible...
Abstract Objective Myelodysplastic syndromes (MDS), caused by various genetic mutations in hematopoietic stem cells, are associated with highly variable outcomes. Poly (ADP‐ribose) polymerase‐1 (PARP1) plays an important role DNA damage repair and contributes to the progression of several types cancer. Here, we investigated impact PARP1 V762A polymorphism on susceptibility prognosis MDS. Methods Samples collected from 105 MDS patients 202 race‐matched healthy controls were subjected...
A network of myelinated nerve fibers in the peritoneum covers abdominal wall. We studied topographic distribution this network, explored fibers' destination central nervous system, and examined markers these order to identify nature sensation conveyed by rats. used Sihler's method, which stains whole mount materials, observed a dense endings toward peritoneal cavity that abdomen's lateral bulge. axonal transport cholera toxin subunit B investigate projections its function. After applying...
The renal nerve plexus comprises efferent and afferent fibers. It controls urine production bodily fluid homeostasis. Efferent fibers to the kidney include sympathetic from their main ganglia, prevertebral suprarenal ganglia (SrG), paravertebral chain (ChG). In present study, we examined topological innervation these parenchymal segments of left rat. Fluoro-Gold was injected into rostral or caudal poles kidney. Approximately 50% cells in SrG rats pole were labeled, while 60% ChG T13 labeled....
Backgrounds & Aims: X-ray repair cross-complementing group 1 (XRCC1) plays an important role in base excision (BER) system, which is critical for genome maintenance. Polymorphisms XRCC1 that result alteration of DNA capacity are reportedly associated with cancer risk and treatment response. However, whether these polymorphisms alter the susceptibility clinical outcomes patients myelodysplastic syndromes (MDS) unknown. The aim this study was to evaluate association two polymorphisms,...
Recently, we identified a novel human platelet-derived growth factor (PDGF) receptor α mRNA (type II) that differs from the known PDGF I) only in its 5′-untranslated region and is regulated by E2F-1. In this study, determined nucleotide sequence of mouse type II found expression transcript was E2F-1 through an E2F-1-responsive located +711/+718 downstream transcription start site I transcript. Furthermore, observed embryo-predominant
Nerves in the renal parenchyma comprise sympathetic nerves that act on arteries and tubules to decrease blood flow increase primary urine reabsorption, respectively. Synaptic vesicles release neurotransmitters activate their effector tissues. However, mechanisms by which exert individual responses cells remain unknown. Here, we investigated spatial molecular compositional associations of Schwann (SC) supporting nerve terminals male rats. The vascular smooth muscle (SMCs) enclosed SC...