A5013650859- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Kruppel-like factors research
- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- Eosinophilic Disorders and Syndromes
- Diabetes Treatment and Management
- Immunotherapy and Immune Responses
- Chronic Myeloid Leukemia Treatments
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Pancreatic function and diabetes
- Platelet Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Silkworms and Sericulture Research
- Complement system in diseases
- Blood groups and transfusion
- Viral-associated cancers and disorders
- T-cell and Retrovirus Studies
- Otitis Media and Relapsing Polychondritis
- Bone and Joint Diseases
- Rangeland Management and Livestock Ecology
- Hematopoietic Stem Cell Transplantation
- Optimal Power Flow Distribution
- Herpesvirus Infections and Treatments
- Electrolyte and hormonal disorders
Memorial Sloan Kettering Cancer Center
2023-2024
Jichi Medical University
2023-2024
Kettering University
2024
Juntendo University Shizuoka Hospital
2021-2023
Juntendo University
2016-2022
Boston University
2019
Seattle University
2019
Hudson Institute
2019
Merck Institute for Science Education
2019
John Wiley & Sons (United States)
2019
Abstract Objectives To efficiently detect somatic UBA1 variants and establish a clinical scoring system predicting patients with pathogenic in VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome. Methods Eighty-nine Japanese clinically suspected syndrome were recruited [81 males 8 females; median age of onset 69.3 years (interquartile range 62.1–77.6)]. Peptide nucleic acid–clamping PCR (PNA-PCR), regular targeting exon 3 clustering subsequent Sanger sequencing...
Background Tumor immune microenvironment (TIME) and cancer antigen expression, key factors for the development of immunotherapies, are usually based on data from primary tumors due to availability tissue analysis; metastatic sites their concordance with tumor lacking. Although same origin tumor, organ-specific differences in TIME metastases may contribute discordant responses checkpoint inhibitor agents. In immunologically ‘cold’ tumors, antigen-targeted chimeric receptor (CAR) T-cell...
We previously reported that sodium–glucose cotransporter 2 (SGLT2) inhibitors exert sustained fluid homeostatic actions through compensatory increases in osmotic diuresis-induced vasopressin secretion and intake. However, SGLT2 alone do not produce durable amelioration of retention. In this study, we examined the comparative effects inhibitor dapagliflozin (SGLT2i group, n = 53) combined use conventional diuretics, including loop diuretics and/or thiazides + diuretic 23), on serum copeptin,...
Summary Somatic mutations in the calreticulin ( CALR ) gene have been found most patients with JAK 2 ‐ and MPL ‐unmutated Philadelphia chromosome‐negative myeloproliferative neoplasms MPN s). It has recently shown that mutant constitutively activates thrombopoietin receptor and, thus, plays a causal role development of s. However, roles human haematopoietic cell differentiation remain predominantly elusive. To examine impact 5‐base insertion (Ins5) on differentiation, we generated induced...
Sodium glucose cotransporter 2 (SGLT2) inhibitors have both glucose-lowering and diuretic effects. We recently reported that the SGLT2 inhibitor dapagliflozin exerts short-term fluid homeostatic action in patients with chronic kidney disease (CKD). However, long-term effects of on body status CKD remain unclear. This was a prospective, non-randomized, open-label study included treatment group ( n = 73) control 24) who were followed for 6 months. Body volume measured using bioimpedance...
There are currently 2 representative diagnostic criteria for essential thrombocythemia (ET), the 2014 British Committee Standards in Hematology Guidelines (BCSH) and 2016 World Health Organization (WHO) criteria. We compare discuss advantages disadvantages of criteria.We applied to 403 patients with thrombocytosis suspected myeloproliferative neoplasms (MPN) compared patient populations.The BCSH diagnosed ET 279 (BCSH-ET) whereas WHO 203 (WHO-ET). were 83 diagnosable only by (BCSH-only-ET),...
Abstract Objective Prefibrotic/early primary myelofibrosis (pre‐PMF) and essential thrombocythemia (ET) exhibited different features of bone marrow; however, this is not always easy to judge objectively, making pathologists’ distinction often suboptimal. In the WHO 2008 criteria, pre‐PMF was defined as a subgroup PMF; therefore, affected patients were at higher risk misdiagnosis with ET. study, we examined prevalence among those previously diagnosed ET in Japan. Method We reviewed marrow...
In myelodysplastic/myeloproliferative neoplasms (MDS/MPN) with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T), somatic mutation in the Splicing Factor 3B subunit 1 gene (SF3B1) at rate of approximately 85% was concurrently found one MPN driver mutations, such as JAK2 V617F (50%), calreticulin (CALR) exon 9 (1–3%) MPL W515 (0–3%) mutations (Patnaik Tefferi 2017). Impaired erythropoiesis induced by mutant SF3B1 (Mupo et al, 2017, Obeng 2016), an increase or more lineages blood cells...
Abstract A subset of essential thrombocythemia (ET) cases are negative for disease-defining mutations on JAK2 , MPL and CALR defined as triple (TN). The lack recurrent in TN-ET patients makes its pathogenesis ambiguous. Here, we screened 483 with suspected ET a single institution, centrally reviewed bone marrow specimens, identified 23 patients. Analysis clinical records revealed that were mostly young female, without history thrombosis or progression to secondary myelofibrosis leukemia....
Immune checkpoint inhibitors (ICIs) are widely used for the treatment of various cancers. However, paradoxical exacerbation neoplasms, referred to as "hyperprogressive disease," has been reported in a proportion patients treated with anti-programmed cell death-1 (PD-1)/PD-1 ligand (PD-L1) blockade. We herein report case acute adult T-cell leukemia (ATL) that developed shortly after administration nivolumab, PD-1 inhibitor, treat non-small-cell lung cancer. There were no signs ATL before and...
Paroxysmal cold hemoglobinuria (PCH) is an extremely rare subtype of autoimmune hemolytic anemia (AIHA) in adults. PCH caused by the biphasic Donath-Landsteiner (DL) antibody which fixes complement to red blood cells at low temperatures and dissociates warmer temperatures, leading complement-mediated intravascular hemolysis. Autoimmune hematological disorders including AIHA immune thrombocytopenia have been reported develop following mRNA COVID-19 vaccination. However, developing subsequent...
Abstract On-target off-tumor toxicity, cytokine release syndrome (CRS), and immune effector cell-associated neurotoxicity (ICANS) are severe immune-related adverse events (irAEs) that frequently associated with Chimeric Antigen Receptor (CAR) T-cell therapy. Current efforts to manage such therapy-related toxicities involve incorporation of an inducible suicide agent within CAR constructs, as iCaspase-9 or herpes simplex virus type 1 thymidine kinase can be selectively activated produce toxic...
Femoral marrow magnetic resonance imaging (MRI) is a non-invasive, non-irradiated and useful modality for evaluating bone (BM) conditions. Human adult femoral BM almost uniformly fatty has the largest volume of single bone. MRI an extremely high resolution fat water, which allows high-contrast cellular infiltration into tissue. In hematological diseases, can clearly detect cell infiltration, symmetrically imaged from proximal to distal direction abnormal signal areas. Thus, we investigated...
Bendamustine-rituximab (BR) therapy has been established as a highly effective regimen for indolent non-Hodgkin lymphoma (NHL). However, patients who receive BR exhibit persistent hypogammaglobulinemia and lymphopenia, resulting in an increased incidence of infections. As sustained immunosuppressive state is risk factor infections, early predictive biomarkers infections related to need be identified. We retrospectively analyzed 61 with NHL were followed up 2 years after the end therapy....
The prognosis of Philadelphia chromosome-negative myeloproliferative neoplasms is relatively favorable, but the quality life can be severely affected by neoplasm-related symptoms such as fatigue, pruritus, night sweats, bone pain, fever and weight loss. In this study, we administered hochuekkito, a traditional herbal medicine, to patients with investigated whether there was reduction in symptoms.We conducted randomized parallel-group pilot study. Patients were assigned hochuekkito...