A5005889408- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Kruppel-like factors research
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Fungal Infections and Studies
- Hemoglobinopathies and Related Disorders
- Eosinophilic Disorders and Syndromes
- Cancer Mechanisms and Therapy
- Antifungal resistance and susceptibility
- Macrophage Migration Inhibitory Factor
- Galectins and Cancer Biology
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Hereditary Neurological Disorders
- Peripheral Neuropathies and Disorders
- Infectious Diseases and Mycology
- Renal Diseases and Glomerulopathies
- CNS Lymphoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Actinomycetales infections and treatment
- Virus-based gene therapy research
- Pneumocystis jirovecii pneumonia detection and treatment
Juntendo University
2014-2024
Tokyo Metropolitan Komagome Hospital
2017-2024
Juntendo University Hospital
2023
Deleted Institution
2021
Centre National pour la Recherche Scientifique et Technique (CNRST)
2021
The Japanese Data Center for Hematopoietic Cell Transplantation
2020
Persistent COVID-19 is a well recognized issue of concern in patients with hematological malignancies. Such are not only at risk mortality due to the infection itself, but also suboptimal malignancy-related outcomes because delays and terminations chemotherapy. We report two lymphoma heavily pretreated persistent which ensitrelvir brought about radical changes clinical course leading rapid remissions. Patient 1 was on ibrutinib treatment for mantle cell when he developed pneumonia severe...
Since MPL mutation is a rare driver gene found in small number of essential thrombocythemia (ET) patients, the clinical characteristics patients with mutations and their association thrombotic events have not yet been elucidated Japan.We enrolled 579 Japanese ET based on diagnostic criteria WHO classification 2017 compared MPL-mutated (n = 22; 3.8%) to JAK2V617F-mutated 299; 51.6%), CALR-mutated 144; 24.9%), triple-negative (TN) 114; 19.7%) patients.Thrombosis during follow up was observed 4...
There are currently 2 representative diagnostic criteria for essential thrombocythemia (ET), the 2014 British Committee Standards in Hematology Guidelines (BCSH) and 2016 World Health Organization (WHO) criteria. We compare discuss advantages disadvantages of criteria.We applied to 403 patients with thrombocytosis suspected myeloproliferative neoplasms (MPN) compared patient populations.The BCSH diagnosed ET 279 (BCSH-ET) whereas WHO 203 (WHO-ET). were 83 diagnosable only by (BCSH-only-ET),...
Summary Risk‐adapted therapy is recommended to prevent major clinical complications, such as thrombo‐haemorrhagic events, in patients with essential thrombocythaemia (ET). In this study, we analysed the association between non‐driver gene mutations and events 579 ET. ASXL1 TP53 were frequently identified ET complicated by thrombosis (22.7% 23.1%, respectively), DNMT3A mutation was who experienced haemorrhage (15.2%). Multivariate analyses of thrombosis‐free survival (TFS) revealed that are...
Background The etiology of POEMS syndrome and its associated polyneuropathy have not been fully elucidated. clinical picture POEMS-associated nutritional due to vitamin B6 (VB6) deficiency are strikingly similar, both being typically sensorimotor, symmetrical, stocking glove distribution, more severe in the lower extremities.Case presentation We report two consecutive patients with VB6 who showed unusual rapid drastic recovery polyneuropathies within 6–8 weeks after oral supplementation....
Exophiala dermatitidis infections in patients with hematological malignancies are very rare. Our patient had a blood stream infection caused by E. following the second umbilical cord transplantation (UCBT) after graft failure during first UCBT. To our knowledge, this is report describing breakthrough fungal prophylactic administration of micafungin (MCFG). Therefore, MCFG-treated should be monitored for hematopoietic stem cell transplantation.
Neurological symptoms induced by the infiltration of malignant lymphoma into nervous systems are subsumed under term neurolymphomatosis (NL). Here, we report case a 30-year-old Japanese man with primary testicular complicated, as seen in various neurological findings, secondary NL prior to swelling. Painless right scrotal enlargement was noticed more than 1 month after appearance complications such upper extremity numbness, dysarthria, facial palsy, and diplopia. Proactive investigation...
A proportion of patients with polycythemia vera (PV) and essential thrombocythemia (ET) harbor non-driver mutations associated poor prognosis. In this study, we analyzed the frequency in a large Japanese PV ET cohort. Furthermore, studied relationship these prognosis patients.We enrolled 843 or ET. Non-driver were by target resequencing using next-generation sequencing. The association was estimated multivariable logistic regression analysis log-rank test.Non-driver detected 31.1% 24.5% ET,...