A5090470146- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Eosinophilic Disorders and Syndromes
- Kruppel-like factors research
- Chronic Lymphocytic Leukemia Research
- Platelet Disorders and Treatments
- Cytokine Signaling Pathways and Interactions
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Hemoglobinopathies and Related Disorders
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- Lipid metabolism and disorders
- FOXO transcription factor regulation
- Signaling Pathways in Disease
- Blood groups and transfusion
- Viral-associated cancers and disorders
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Protein Degradation and Inhibitors
- Erythrocyte Function and Pathophysiology
- Hematopoietic Stem Cell Transplantation
- Cell death mechanisms and regulation
University of Yamanashi
2016-2025
University of Yamanashi Hospital
2007-2024
Ministry of Health Labour and Welfare
2021
Weatherford College
2021
Jichi Medical University
1996-2004
University of California, San Diego
2003-2004
Osaka University
1998-2002
Kirin (Japan)
2002
Hokkaido University
2000-2002
University of Tsukuba
1997-2002
RESPONSE is an open-label phase 3 study evaluating the Janus kinase 1/Janus 2 inhibitor ruxolitinib versus best available therapy for efficacy/safety in hydroxyurea-resistant or intolerant patients with polycythemia vera. This preplanned analysis occurred when all completed Week 80 visit discontinued. Objectives included durability of primary response (Week 32 phlebotomy-independent hematocrit control plus ≥35% spleen volume reduction), its components, and that complete hematologic...
A member of the Forkhead transcription factor family, FKHRL1, lies downstream phosphatidylinositol 3-kinase-Akt activation pathway in cytokine signaling. Because is required for BCR-ABL-mediated transformation and survival signaling chronic myelogenous leukemia (CML), this study we examined involvement FKHRL1 pathway. was constitutively phosphorylated BCR-ABL-expressing cell lines KCL22 KU812, its phosphorylation inhibited by treatment with STI571, a specific inhibitor BCR-ABL tyrosine...
Neolacto-series gangliosides having linear poly-N-acetyl-lactosaminyl oligosaccharide structure have been demonstrated to be increased characteristically during granulocytic differentiation of human promyelocytic leukemia cell line HL-60 cells induced by dimethyl sulfoxide or retinoic acid (Nojiri, H., Takaku, F., Tetsuka, T., Motoyoshi, K., Miura, Y., and Saito, M. (1984) Blood 64, 534-541). When were cultured in the presence neolacto-series prepared from mature granulocytes, found...
Thrombopoietin (TPO), an essential factor for megakaryopoiesis and thrombopoiesis, works as a survival megakaryocytic lineage cells. However, little is known about the molecular mechanism in detail. We show here that TPO supports of TPO-dependent leukemia cell line UT-7/TPO normal progenitors via induction Bcl-xL, anti-apoptotic member Bcl-2 family. further analyzed signal transduction pathways required TPO-induced Bcl-xL gene expression. A reporter assay with various lengths Bcl-x promoter...
Abstract Polycythemia vera (PV) is a myeloproliferative neoplasm associated with high symptom and psychological burden, resulting in decreased quality of life (QoL). Patients PV have an increased risk cardiovascular (CV) complications, making regular monitoring crucial. The Landmark 2.0 survey was conducted worldwide among patients their treating physicians to identify any potential gaps perceptions regarding management. Data were collected between April 2021 2022 from across 11 countries....
Excessive reactive oxygen species (ROS) are toxic to hematopoietic cells. The majority of cellular ROS derived from mitochondria and glucose metabolism, cytokines stimulate this process. During hypoxia, hypoxia inducible factor-1 (HIF-1) attenuates hypoxia-induced mitochondrial production through the induction pyruvate dehydrogenase kinase-1 (PDK-1). Previously, we found that thrombopoietin (TPO) induces generation ROS. Interestingly, TPO-induced promotes activation HIF-1. Based on these...
Members of the homeobox family transcription factors are major regulators hematopoiesis. Overexpression either HOXB4 or HOXA9 in primitive marrow cells enhances expansion hematopoietic stem (HSCs). However, little is known how expression function these proteins regulated during hematopoiesis under physiological conditions. In our previous studies we demonstrated that thrombopoietin (TPO) levels mRNA (K. Kirito, N. Fox, and K. Kaushansky, Blood 102:3172-3178, 2003). To extend studies,...
Abstract Erythropoietin (EPO) can rescue erythroid cells from apoptosis during development, leading to red cell production. However, the detailed mechanism of how EPO protects is still open question. To address this problem, we used a human EPO‐dependent leukemia line UT‐7/EPO and normal progenitor cells. After deprivation EPO, underwent apoptosis, accompanied by down‐regulation Bcl‐xL protein. In addition, cleaved products caspase‐3, p11 p21, few forms inhibitor caspase‐activated DNase...
The Janus kinase (JAK)-signal transducers and activators of transcription (STAT) pathway is an important signaling interferons cytokines. We examined the activation STAT proteins induced by interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), or erythropoietin (EPO) using human leukemia cell line, UT-7, which requires these cytokines for growth. IL-3, GM-CSF, EPO DNA-binding activity to oligonucleotides corresponding sis-inducible elements (SIE) c-fos, in addition...
FKHRL1 (also called FOXO3a) is a member of the Forkhead Box, class O (FOXO) subfamily forkhead transcription factors and functions downstream Bcr–Abl tyrosine kinase as phosphorylated inactive form in chronic myelogenous leukemia (CML). The inhibitor imatinib induces cell cycle arrest subsequent apoptosis via conversion from to dephosphorylated active CML‐derived lines. In present study, we examined whether can overcome resistance imatinib. To this end, generated 4‐hydroxytamoxifen‐inducible...
Abnormal activation of hypoxia-inducible factor-1 (HIF-1), one the most important transcription factors for adaptation cells to hypoxia, is frequently observed in numerous types solid tumors. Dysregulation HIF-1 induces tumor angiogenesis and enhances expression anti-apoptotic proteins glycolysis-associated enzymes cancer cells, which turn leads promotion growth. In present study, we examined pathophysiologic role multiple myeloma. Furthermore, explored possibility that may be a molecular...