A5011340584- Acute Myeloid Leukemia Research
- Cardiac Imaging and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- Biochemical and Molecular Research
- Cancer therapeutics and mechanisms
- Cardiovascular Function and Risk Factors
- Gout, Hyperuricemia, Uric Acid
- DNA Repair Mechanisms
- Neutropenia and Cancer Infections
- Protease and Inhibitor Mechanisms
- HIV/AIDS drug development and treatment
- Cardiac Fibrosis and Remodeling
- Retinoids in leukemia and cellular processes
- Cell death mechanisms and regulation
- Cancer Treatment and Pharmacology
- RNA Interference and Gene Delivery
- Eosinophilic Disorders and Syndromes
- Advanced MRI Techniques and Applications
- DNA and Nucleic Acid Chemistry
- Hematological disorders and diagnostics
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
University of Fukui
2015-2024
IBM (United States)
2023
Tsukuba Medical Center Hospital
2012-2021
Tokyo Metropolitan Bokutoh Hospital
2021
Matsunami General Hospital
2021
Tohoku University
2019-2021
IBM Research - Tokyo
2016-2018
Hiroshima General Hospital
2017
Iwate Medical University
2013-2016
Aichi Human Service Center
2015
The microservice architecture is a new framework to construct Web service as collection of small services that communicate with each other. It becoming increasingly popular because it can accelerate agile software development, deployment, and operation practices. As result, cloud providers are expected host an increasing number microservices generate significant resource pressure on the infrastructure. We want understand characteristics workloads design infrastructure optimized for...
Computing, since its inception, has been processor-centric, with memory separated from compute. Inspired by the organic brain and optimized for inorganic silicon, NorthPole is a neural inference architecture that blurs this boundary eliminating off-chip memory, intertwining compute on-chip, appearing externally as an active chip. low-precision, massively parallel, densely interconnected, energy-efficient, spatial computing co-optimized, high-utilization programming model. On ResNet50...
Recent molecular analyses in several plant species revealed that TERMINAL FLOWER1 (TFL1) and CENTRORADIALIS (CEN) homologs are involved regulating the flowering time and/or maintaining inflorescence meristem. In apple (Malusxdomestica Borkh.), four TFL1/CEN-like genes, MdTFL1, MdTFL1a, MdCENa MdCENb, were found mapped by a similar position on putatively homoeologous linkage groups. Apple genes functioned equivalently to TFL1 when expressed constitutively transgenic Arabidopsis plants,...
1 Laboratory for Applied Biological Regulation Technology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyusyu University, 6-10-1 Hakozaki, Higashiku, Fukuoka 812-8581, Japan 2 Institute Basic Medical University Tsukuba, 1-1-1 Tennodai, Ibaraki 305-8575, 3 Bioscience Division, Mitsui Knowledge Industry Co., Ltd, Harmony tower 21th Floor, 1-32-2 Honcho, Nakano-ku, Tokyo 164-8721,
Background: Allopurinol has been widely used for treatment of hyperuricemia, however, it may be associated with various adverse effects. Febuxostat is potentially a safe and efficacious alternative. Objectives: or allopurinol was administered to patients hyperuricemia including gout 8 weeks compare the efficacy safety these drugs. Methods: Doses febuxostat were 10 100 mg/d, respectively, during 12-day introduction period increased 40 200 mg/d subsequent 44 days. Results: The percent changes...
Aims: Circulating endothelial progenitor cells (EPCs) were mobilized in cardiac ischemia, heart failure and vascular injuries associated with damage. Despite the occurrence of dysfunction peripheral artery disease (PAD), few data are available on EPC mobilization this setting.Methods: We investigated correlations between severity also other biomarkers PAD. EPCs assessed as CD34+ co-expressing CD45dim, CD133 growth factor receptor-2 studied PAD (n =48) non-PAD =22) patients. Membrane type-1...
Abstract Reflecting the increasing risk in elderly patients with diffuse large B cell lymphoma (DLBCL), prognostic predictors other than International Prognostic Index have attracted more attention. This study presents first analysis of utility Geriatric Nutritional Risk (GNRI) combination Charlson Comorbidity (CCI) for overall survival (OS) DLBCL patients. A multicentre retrospective was conducted on a cohort 451 (≥65 years). The GNRI and CCI were independent multivariate Cox proportional...
BackgroundPatients with tsutsugamushi disease sometimes die if they do not receive appropriate chemotherapy. This study measured the concentration of several cytokines both before and after administration tetracyclines, evaluated changes in cytokine levels patient serum to investigate relationship between severity.MethodsA total nine patients were infected Orientia tsutsugamushi. The diagnosis was made using an indirect immunoperoxidase antibody test. concentrations enzyme-linked...
Allopurinol has been widely used for the treatment of hyperuricemia, however, it may be associated with various adverse effects. Febuxostat identified as a potentially safe and efficacious alternative.Febuxostat was administered to patients hyperuricemia including gout in Japan compare its efficacy safety those allopurinol.The starting dose febuxostat allopurinol 10 100 mg/d, respectively, increased fixed maintenance 40 or 60 mg/d 300 16 weeks.: The percent change serum uric acid level at...
Tumor lysis syndrome (TLS) is a life-threatening complication associated with cancer chemotherapy. We retrospectively evaluated the risk of developing TLS in patients symptomatic multiple myeloma undergoing chemotherapy.Sixty-four (median age=71 years, range=48-87 35 males/29 females) who were treated at our Institution between April 2006 and December 2015 evaluated.A total 124 chemotherapy courses administered, which 63 bortezomib-based regimens 34 immunomodulatory drug (IMiD)-based...
Camptothecin (CPT) has heen recognized as a topoisomerase I (Topo I) inhibitor. However, the mechanism of cytotoxicity this agent remains unknown. In present study, we analyzed kinetics Topo I‐mediated DNA single‐strand breaks and internucleosomal cleavage produced by CPT its derivative, 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), in HL‐60 cells. single‐ strand were detected using alkaline sucrose gradient centrifugation when cells incubated with 10 μM or SN‐38 for 30 min. These rapidly repaired...
Recent reports have shown that antibiotics such as macrolide, aminoglycoside, and tetracyclines immunomodulatory effects in addition to essential antibiotic effects. These agents may important on the regulation of cytokine chemokine production. However, precise mechanism is unknown. This time, we used Multi Plex measure production cytokines chemokines following tetracycline treatment lipopolysaccharide (LPS)-induced THP-1 cells. The signaling pathways were investigated with Western blotting...