A5053201407- Systemic Lupus Erythematosus Research
- Otitis Media and Relapsing Polychondritis
- Vascular Anomalies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Congenital Ear and Nasal Anomalies
- Ocular Diseases and Behçet’s Syndrome
- Musculoskeletal synovial abnormalities and treatments
- Sarcoidosis and Beryllium Toxicity Research
- Patient-Provider Communication in Healthcare
- Peripheral Neuropathies and Disorders
- Sodium Intake and Health
- Healthcare Systems and Technology
- Immunodeficiency and Autoimmune Disorders
- Vasculitis and related conditions
- Cardiac electrophysiology and arrhythmias
- Peptidase Inhibition and Analysis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Histone Deacetylase Inhibitors Research
- Pregnancy-related medical research
- Chronic Lymphocytic Leukemia Research
- Pregnancy and preeclampsia studies
- Biosimilars and Bioanalytical Methods
- Reproductive System and Pregnancy
Yokohama City University
2015-2024
Duke-NUS Medical School
2021-2024
Yokohama City University Medical Center
2016-2018
To determine clinical and genetic features of individuals with relapsing polychondritis (RP) likely caused by pathogenic somatic variants in ubiquitin-like modifier activating enzyme 1 (UBA1).Fourteen patients RP who met the Damiani Levine criteria were recruited (12 men, 2 women; median onset age (IQR) 72.1 years (67.1-78.0)). Sanger sequencing UBA1 was performed using genomic DNA from peripheral blood leukocytes or bone marrow tissue. Droplet digital PCR (ddPCR) peptide nucleic acid...
Interstitial lung disease (ILD) is the principal cause of death in polymyositis/dermatomyositis (PM/DM). Here we investigated prognostic factors for and serious infection PM/DM-ILD using multicenter database. We retrospectively reviewed baseline demographic, clinical laboratory findings, treatment regimens outcomes patients with PM/DM-ILD. The distribution ILD lesions was evaluated four divided zones high-resolution computed tomography images. Of 116 PM/DM-ILD, 14 died within 6 months from...
We have reported earlier that a high salt intake triggered an aestivation-like natriuretic-ureotelic body water conservation response lowered muscle mass and increased blood pressure. Here, we tested the hypothesis similar adaptive occurs in experimental chronic renal failure.In four subsequent experiments Sprague Dawley rats, used surgical 5/6 reduction (5/6 Nx) to induce failure. studied solute excretion 24-hour metabolic cage experiments, pressure by radiotelemetry, adjustment liver...
Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is an autoinflammatory disease caused by variants in the UBA1 gene that lead to severe systemic inflammation and myelodysplastic syndrome. Although no standard therapy has been established yet, azacitidine bone marrow transplantation have reported be promising possibilities; however, indications for these treatments are problematic not necessarily applicable all patients. We previously results of short-term treatment...
It has been suggested that the phenotypes of Behçet's disease (BD) in Japan are changing. To ask whether evolution BD holds true recent-onset cases Japan, we performed a retrospective study. We reviewed records 578 patients with who met 1987 revised diagnostic criteria research committee Japan. The were divided into three groups based on date onset. compared demography, clinical features, and treatments among them or without adjustment for observation period. Patients having oral ulcers,...
Abstract Objectives To efficiently detect somatic UBA1 variants and establish a clinical scoring system predicting patients with pathogenic in VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome. Methods Eighty-nine Japanese clinically suspected syndrome were recruited [81 males 8 females; median age of onset 69.3 years (interquartile range 62.1–77.6)]. Peptide nucleic acid–clamping PCR (PNA-PCR), regular targeting exon 3 clustering subsequent Sanger sequencing...
Innate immunity including macrophages (Mϕ) in lupus nephritis (LN) has been gaining attention, but roles of Mϕ LN remain uncertain. Immunohistochemical staining was performed to determine CD68, CD163, heme oxygenase (HO)-1 (a stress-inducible heme-degrading enzyme with anti-inflammatory property), pSTAT1, and CMAF-expressing the glomeruli patients LN. Effects type I interferons on expression levels HO-1, BTB CNC homology 1 (Bach1; a transcriptional HO-1 repressor), interleukin (IL)-6, IL-10...
To compare the findings in rheumatoid arthritis (RA)-affected joints between (18)F-fluorodeoxyglucose (FDG) and (18)F-fluoride (NaF) positron emission tomography (PET)/computed (CT).We enrolled twelve RA patients who started a new biologic agent (naïve 9 switch 3). At entry, both hands were examined by (18)F-FDG PET/CT, (18)F-NaF X-ray. Intensity of PET signals was determined standardized uptake value max (SUVmax) metacarpophalangeal (MCP), proximal interphalangeal (PIP), ulnar, medial,...
Patients with adult-onset Still's disease (AOSD) are at risk of developing macrophage activation syndrome (MAS), a life-threatening condition. Some cases MAS have been reported following the use biological agents, highlighting need to identify contributing factors. This study aims examine characteristics in patients AOSD treated anakinra (ANA) or tocilizumab (TCZ). A systematic search was conducted across four online databases studies reporting incidence rates ANA TCZ. Meta-analysis...
Infection is a leading cause of death in patients with systemic lupus erythematosus (SLE). Alt hough hydroxychloroquine (HCQ) has been reported to inhibit infection, evidence from Asian populations remains insufficient. We investigated this effect Japanese SLE patients.Data the Lupus Registry Nationwide Institutions were used study. The ≥20 years old and met American College Rheumatology (ACR) classification criteria revised 1997. defined "severe infections" as those requiring...
TRIM21 is a member of the tripartite motif family proteins and one autoantigens which react with anti-SS-A antibody (Ab) present in sera patients systemic lupus erythematosus (SLE) Sjögren's syndrome. Previous studies have shown that dysfunction promotes aberrant B-cell differentiation Ab production SLE, anti-TRIM21 may be related to human SLE pathogenesis. Here, we examined relationship between clinical immunological characteristics patients.Twenty-seven (23 women four men) before...
To determine combined evaluation of musculoskeletal ultrasonography (MSUS) and power Doppler (PD) signals, anti-citrullinated peptide antibody (ACPA), other clinical findings improve the prediction joint destruction in rheumatoid arthritis (RA).We performed a retrospective study 331 RA patients (female n = 280 male 51, mean age: 57.9 ± 13.2 years) who underwent MSUS from 2002 to 2012. Correlations with progression destructions 1,308 2nd 3rd metacarpophalangeal (MCP) joints various factors...
Few studies have explored whether the involvement of patients in shared decision-making (SDM) is beneficial to management systemic lupus erythematosus (SLE). Therefore, this study investigated relationship between patient participation SDM and their trust physicians using data from Trust Measurement Physicians Patients With SLE (TRUMP2-SLE) study.
ABSTRACT Objectives Few studies have explored whether the involvement of patients in shared decision-making (SDM) is beneficial to management systemic lupus erythematosus (SLE). Therefore, this study investigated relationship between patient participation SDM and their trust physicians using data from TRUMP2-SLE study. Methods Data regarding nine-item Shared Decision-Making Questionnaire (SDM-Q-9 scores), Trust Physician Scale (TIPS) scores, Abbreviated Wake Forest (A-WFPTS) scores for...
Background: Pre-clinical evidence suggests that blood pressure (BP) increase is part of an adaptive physiological body response designed to prevent under-hydration. This idea challenges established thinking hypertension caused by initial salt-driven over-hydration. We tested the hypothesis this alternative view also holds true in humans. Methods: In a mechanistic study, we investigated interrelation between daily Na + and water intake, renal solute excretion, conservation, balance with BP 6...
Background: Textbook teaching pretends that Na + -driven extracellular fluid and blood volume expansion may cause hypertension. We tested the alternative hypothesis, namely K loss-driven intracellular contraction causes Methods: effect of deoxycorticosterone acetate (DOCA; 25 mg pellet) in mice on low diet (0.02-0.03%) without (tap water), or with their drinking water (1% NaCl 1.44% NaHCO 3 ). measured BP radio-telemetry, analysed body , content 2, 6, 12 days after initiation DOCA treatment....
<h3>Background:</h3> Recently, shared decision-making (SDM) has become an important process in medical care, extending its significance to the management of systemic lupus erythematosus (SLE)<sup>1</sup>. However, there are still few reports on relationship between SDM and improvement quality life (QoL) patients with SLE. <h3>Objectives:</h3> This study aimed analyze data from a multi-institutional SLE cohort Japan examine potential contribution QoL. <h3>Methods:</h3> The employed...