A5036460159- Reproductive Biology and Fertility
- Ovarian function and disorders
- Reproductive Health and Technologies
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Maternal and fetal healthcare
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and preeclampsia studies
- Sperm and Testicular Function
- Renal and related cancers
- Childhood Cancer Survivors' Quality of Life
- Family Support in Illness
- Glycosylation and Glycoproteins Research
- Cancer Risks and Factors
- Galectins and Cancer Biology
- Ectopic Pregnancy Diagnosis and Management
- Endometriosis Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Reproductive System and Pregnancy
- Gestational Trophoblastic Disease Studies
- Uterine Myomas and Treatments
- Lung Cancer Research Studies
- Maternal and Perinatal Health Interventions
- Cancer survivorship and care
- Cancer Research and Treatments
St. Marianna University School of Medicine
2016-2025
Creative Commons
2018
Yale University
2018
Tokyo Metropolitan Police Hospital
2016
Suzuki (Japan)
2016
Kitasato University
2016
Juntendo University
2016
Iwate Medical University
2016
Northwestern University
2015
Merck Serono (Switzerland)
2015
Significance Human ovaries hold follicles containing oocytes. When mature, they release eggs for fertilization. Patients with primary ovarian insufficiency develop menopausal symptoms at less than 40 y of age. They have few remaining and their only chance bearing a baby is through egg donation. Kawamura et al. demonstrated that Hippo Akt signaling pathways regulate follicle growth. Using an in vitro activation approach, first removed from infertile patients, followed by fragmentation to...
STUDY QUESTIONIs ovarian tissue cryopreservation using vitrification followed by in vitro activation (IVA) of dormant follicles a potential approach for infertility treatment patients with primary insufficiency (POI)?
Fertility preservation (FP) is an important quality of life issue for cancer survivors reproductive age. Despite the existence broad international guidelines, delivery oncofertility care, particularly amongst paediatric, adolescent and young adult patients, remains a challenge healthcare professionals (HCPs). The care variable uptake utilization FP low. Available guidelines fall short in providing adequate detail on how models (MOC) allow real-world application by HCPs.
Clear cell carcinoma (CCC) is a rare histologic subtype that demonstrates poor outcomes in epithelial ovarian cancer. The Japanese Gynecologic Oncology Group conducted the first randomized phase III, CCC-specific clinical trial compared irinotecan and cisplatin (CPT-P) with paclitaxel plus carboplatin (TC) patients CCC.Six hundred sixty-seven stage I to IV CCC of ovary were randomly assigned receive 60 mg/m(2) on days 1, 8, 15 day 1 (CPT-P group) every 4 weeks for six cycles or 175 area...
Despite recent advances in diagnosis and treatment of lung cancers, the 5-year survival rate remains unsatisfactory, which necessitates identification novel factors that associates with disease progression malignant degree for improving diagnostic therapeutic strategies. Recent progress cancer immunology research has unveiled critical roles colony stimulating factor 1 receptor (CSF1R) multiple aspects tumor microenvironment. CSF1R is expressed on tumor-associated macrophages (TAMs), mediates...
This phase III, multicenter, randomized, open-label study investigated the efficacy and safety of nivolumab versus chemotherapy (gemcitabine [GEM] or pegylated liposomal doxorubicin [PLD]) in patients with platinum-resistant ovarian cancer.
Oncofertility focuses on providing fertility and endocrine-sparing options to patients who undergo life-preserving but gonadotoxic cancer treatment. The resources needed meet patient demand often are fragmented along disciplinary lines. We quantify assets gaps in oncofertility care a global scale.Survey-based questionnaires were provided 191 members of the Consortium Global Partners Network, National Institutes Health-funded organization. Responses analyzed measure trends regional subtleties...
Fertility preservation in the cancer setting, known as oncofertility, is a field that requires cross-disciplinary interaction between physicians, basic scientists, clinical researchers, ethicists, lawyers, educators, and religious leaders. Funded by National Institutes of Health, Oncofertility Consortium (OC) was formed to be scientifically grounded, transparent, altruistic resource, both intellectual monetary, for building this new practice capable addressing unique needs young patients...
PEGL-DOX is an excellent treatment for recurrent ovarian cancer that rarely causes side-effects like cardiotoxicity or hair loss, but frequently results in Hand-Foot Syndrome (HFS). In severe cases, it can become necessary to reduce the concentration duration of drug therapy, sometimes making difficult continue treatment. this study, we prepared animal model compare effects DOX versus PEGL-DOX, and noticed only with resulted HFS, which led us conclude extravasation due long-term circulation...
In 2017, the Japan Society of Clinical Oncology (JSCO) published JSCO Practice Guidelines 2017 for Fertility Preservation in Childhood, Adolescent, and Young Adult Cancer Patients. These were first Japanese guidelines to address issues oncofertility. this field medicine, sustained close cooperation between oncologists reproductive specialists is essential from diagnosis cancer until many years after completion treatment. intended guide multidisciplinary medical staff considering availability...
Trophinin and tastin form a cell adhesion molecule complex that potentially mediates an initial attachment of the blastocyst to uterine epithelial cells at time implantation. tastin, however, do not directly bind each other, suggesting presence intermediary protein. The present study identifies cytoplasmic protein, named bystin, binds trophinin tastin. Bystin consists 306 amino acid residues is predicted contain tyrosine, serine, threonine in contexts conforming motifs for phosphorylation by...
Ovarian tissue cryopreservation by rapid cooling (vitrification) is a convenient fertility preservation option. However, the progress of vitrified ovarian after transplantation not well understood in primates. For tissues from cynomolgus monkeys, we used closed straw vitrification and open cryosupport which are immersed directly into liquid nitrogen. Following warming, cortical pieces were autotransplanted their function was monitored computed tomography (CT), hormone assays oocyte recovery,...
BLM and WRN are RecQ DNA helicasesessential for genomic stability. Here, we demonstrate that HERC2, a HECT E3 ligase, is critical their functions to suppress G-quadruplex (G4) DNA. HERC2 interacted with BLM, WRN, replication protein A (RPA) complexes during the S-phase of cell cycle. Depletion dissociated RPA from significantly increased G4 formation. Triple depletion revealed has an epistatic relationship in G4-suppressing function. In vitro, released onto single-stranded (ssDNA) rather...
Significance A unique characteristic of invariant natural killer T ( i NKT) cells is their ability to immediately produce large amounts interferon-gamma (IFN-γ) upon activation, which enables these play critical roles in initiating immune responses various pathological conditions. In this study, we demonstrate a previously unidentified mechanism mediated by basic helix–loop–helix transcription factor family, member e40 (Bhlhe40) for accelerating IFN-γ production NKT cells. Bhlhe40 required...
Abstract Aim This study aimed to assess the awareness of concept “cardio‐oncology” and cardiovascular disease (CVD) in patients with endometrial cancer (EC) among Japanese Gynecologic Oncology Group members. Methods An online anonymous survey, which consisted questions about respondent attributes cardio‐oncology, was conducted twice, 2022 2024. During these surveys, guidelines for treatment uterine body neoplasm were published July 2023. Results In 2022, significantly numerous physicians...
Abstract Purpose: Of the various microtubule-associated molecules, β-tubulin III has been reported to be closely associated with therapeutic efficacy of taxane-based chemotherapy against ovarian cancer. Stathmin and protein 4 (MAP4) have play an important role in microtubule stabilization. In this study, we investigated whether expression these factors affects clear cell adenocarcinoma. Experimental Design: Drug sensitivity paclitaxel or cisplatin was assessed cancer lines treated small...