A5049923413- Ovarian cancer diagnosis and treatment
- Cancer Treatment and Pharmacology
- Intraperitoneal and Appendiceal Malignancies
- Endometrial and Cervical Cancer Treatments
- Cancer, Lipids, and Metabolism
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Drug Transport and Resistance Mechanisms
- Metal complexes synthesis and properties
- PI3K/AKT/mTOR signaling in cancer
- Chemotherapy-induced organ toxicity mitigation
- Endometriosis Research and Treatment
- Cervical Cancer and HPV Research
- Microtubule and mitosis dynamics
- Cell death mechanisms and regulation
- Testicular diseases and treatments
- Cancer therapeutics and mechanisms
- Colorectal Cancer Treatments and Studies
- Cancer, Hypoxia, and Metabolism
- Estrogen and related hormone effects
- Uterine Myomas and Treatments
- Protein Kinase Regulation and GTPase Signaling
- Genomics, phytochemicals, and oxidative stress
- Chromatin Remodeling and Cancer
- Chemotherapy-related skin toxicity
Jikei University School of Medicine
2012-2022
The Jikei University Hospital
2009-2018
Kitasato University
2016
Juntendo University
2016
Iwate Medical University
2009-2016
Suzuki (Japan)
2016
Research Institute of Radiology
2015
Tokai University
2012
St. Marianna University School of Medicine
2012
Keio University
2012
Abstract Purpose: We aimed to find key molecules associated with chemoresistance in ovarian cancer using gene expression profiling as a screening tool. Experimental Design: Using two newly established paclitaxel-resistant cell lines from an original paclitaxel-sensitive line and four supersensitive refractory surgical specimens paclitaxel-based chemotherapy, were screened arrays containing 39,000 genes. further analyzed 44 genes that showed significantly different expressions between samples...
Clear cell carcinoma (CCC) is a rare histologic subtype that demonstrates poor outcomes in epithelial ovarian cancer. The Japanese Gynecologic Oncology Group conducted the first randomized phase III, CCC-specific clinical trial compared irinotecan and cisplatin (CPT-P) with paclitaxel plus carboplatin (TC) patients CCC.Six hundred sixty-seven stage I to IV CCC of ovary were randomly assigned receive 60 mg/m(2) on days 1, 8, 15 day 1 (CPT-P group) every 4 weeks for six cycles or 175 area...
The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) enhanced sensitivity to cis-diamminedichloroplatinum(II) (DPP) in human ovarina carcinoma 2008 cells by a factor of 2.53 +/- 0.74 fold (S.D.). Sensitization was maximum 3 h after 1-h exposure TPA and had disappeared completely 7 treatment. An equivalent degree sensitization produced variant selected for 10-fold resistance DDP. neither increased nor decreased cellular accumulation Phorbol, analog which does not activate protein...
Abstract Purpose: Although ovarian clear cell carcinomas (OCCC) are commonly resistant to platinum-based chemotherapy, good clinical outcomes observed in a subset of patients. The explanation for this is unknown but may be due misclassification high-grade serous cancer (HGSOC) as OCCC or mixed histology. Experimental Design: To discover potential biomarkers survival benefit following we ascertained cohort 68 Japanese and Australian patients whom progression-free (PFS) overall (OS) could...
The PTEN/MMAC1/TEP1 tumor-suppressor gene, which maps to chromosome 10q23.3, is mutated and homozygously deleted in a variety of human tumors, including endometrioid-type ovarian tumors. We examined 33 primary cancers 3 borderline tumors for allelic imbalance (AI) the 10q23.3 region using 5 polymorphic markers, an insertion/deletion-type marker identified intron 4 PTEN gene. AI at one or more loci was detected 12 31 (39%) informative none commonly mapped between D10S215 D10S541 loci, locus....
The PTEN/MMAC1/TEP1 tumor-suppressor gene, which maps to chromosome 10q23.3, is mutated and homozygously deleted in a variety of human tumors, including endometrioid-type ovarian tumors. We examined 33 primary cancers 3 borderline tumors for allelic imbalance (AI) the 10q23.3 region using 5 polymorphic markers, an insertion/deletion-type marker identified intron 4 PTEN gene. AI at one or more loci was detected 12 31 (39%) informative none commonly mapped between D10S215 D10S541 loci, locus....
5506 Background: Tri-weekly administration with paclitaxel and carboplatin (c-TC) is considered the standard of care for treatment ovarian carcinoma. We compared c-TC dose dense weekly TC (dd-TC) as first-line chemotherapy stage II-IV epithelial ovarian, fallopian tube or primary peritoneal cancer. Methods: randomly assigned patients to receive an area under plasma concentration-time curve 6 either at 180 mg/m2 on day 1 80 days 1, 8, 15. The treatments were repeated every 3 weeks six cycles;...
5003 Background: The primary analysis of the JGOG3016 trial (Lancet 2009, 374:1331) showed that dose-dense weekly administration with paclitaxel and carboplatin (dd-TC) demonstrated statistically significant efficiency over tri-weekly withTC (c-TC) as first-line chemotherapy in patients stage II-IV epithelial ovarian, fallopian tube or peritoneal cancer. We report long-term follow-up results on progression-free survival (PFS) overall (OS). Methods: Patients II to IV ovarian cancer were...
The aim of the study is to investigate recurrence stage I epithelial ovarian cancer.Six hundred two patients diagnosed with cancer at 4 hospitals between 2000 and 2013 were retrospectively analyzed. Age, surgical procedure, substage, histologic type, adjuvant chemotherapy, recurrence, initial site (peritoneal dissemination [P], hematogenous [H], lymphogenous [L], others [O]), frequency each investigated retrospectively.Median age was 54 years median follow-up 60 months. IA in 180 cases...
The objective of this study was to ascertain the evidence on ovarian cancer during pregnancy and compile recommendations derived from information. This a retrospective study, based clinical histories patients diagnosed treated at 4 independent hospitals for pregnancy, between 1992 2009. median age diagnosis 30 years (range, 24-41). Out 10 cases cancer, 2 showed either bleeding or abdominal pain, while 8 were asymptomatic. All via ultrasound, masses detected in first trimester 7 second...
Since there have been few large series studies to date, we investigated the relationship between Trousseau's syndrome associated with cerebral infarction and its clinical associations ovarian cancer.In this study, association onset cancer. Eight-hundred twenty-seven consecutive cancer patients from 4 affiliated academic institutions were included in study over a 12 years period. All histopathologically diagnosed as epithelial analyzed retrospectively.The 27 (3.2%) presented during period, 14...
The effect of an aureolic acid, mithramycin (MTM) on multidrug resistance (MDR) was investigated. At a concentration 0.02--0.1 mg/ml (about 20--90 microM), MTM repressed MDR1 gene transcription SBC-3/ADM, MDR-phenotype subline derived from human small cell lung tumor. Under the same conditions, another chromomycin A3, showed potent cytotoxicity. FACS analysis revealed that 5 microm depleted P-glycoprotein (Pgp) and lowered efflux activity SBC-3/ADM cells. Furthermore, sensitized cells...
5507 Background: CCC is a histologic subtype of epithelial ovarian cancer showing different clinical and biological characteristics. has become well known for its resistance to current standard chemotherapy (PC). Our previous trial demonstrated the potential benefit CPT-P regimen on CCC. Methods: Patients (pts) with Stage I-IV were randomized receive paclitaxel 175mg/m2 plus carboplatin AUC6 IV q3wk or irinotecan 60mg/m2 (days 1, 8, 15) cisplatin (day 1) q4wk 6 cycles. International central...
Struma ovarii exhibiting malignant histology are uncommon, and aggressive clinical courses with initial extraovarian spread even more rare. This report describes a case of struma predominant anaplastic carcinoma component. A 65-yr-old, gravida 2, para female presented lower abdominal discomfort pain. She had 12×10×7.5 cm tumor in the right ovary. Intraoperative diagnosis was high-grade spindle cell tumor. Right salpingo-oophorectomy hysterectomy were performed. Macroscopically, invading tube...