A5007238339- Growth Hormone and Insulin-like Growth Factors
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Cancer Cells and Metastasis
- Pluripotent Stem Cells Research
- Pancreatic function and diabetes
- Mitochondrial Function and Pathology
- Inclusion and Disability in Education and Sport
- Cancer, Hypoxia, and Metabolism
- Protein Kinase Regulation and GTPase Signaling
- PI3K/AKT/mTOR signaling in cancer
- Animal Behavior and Welfare Studies
- Ovarian cancer diagnosis and treatment
- Monoclonal and Polyclonal Antibodies Research
- Liver physiology and pathology
- Neuroendocrine Tumor Research Advances
- HER2/EGFR in Cancer Research
- Behavioral and Psychological Studies
- Animal Nutrition and Physiology
- Disability Rights and Representation
- Animal Behavior and Reproduction
- Molecular Biology Techniques and Applications
- Stress Responses and Cortisol
- Melanoma and MAPK Pathways
- 3D Printing in Biomedical Research
Jikei University School of Medicine
2015-2024
Nippon Dental University Hospital
2013
The Jikei University Hospital
2010
Nihon University
2004
Aichi Human Service Center
2003-2004
Niigata University
2000-2003
Behavioral Pharma (United States)
2002
Aichi Developmental Disability Center
1984-2000
Kyoto University
1996
Tokyo Metropolitan Institute of Medical Science
1982-1985
Abstract To clarify the role of ghrelin in bone metabolism, we examined effect vitro and vivo. Ghrelin its receptor, GHS-R1a, were identified osteoblasts, promoted both proliferation differentiation. Furthermore, increased BMD rats. Our results show that directly affects formation. Introduction: is a gut peptide involved growth hormone (GH) secretion energy homeostasis. Recently, it has been reported adipocyte-derived leptin, which also regulates homeostasis opposes ghrelin's actions...
Elderly people insidiously manifest the symptoms of heart failure, such as dyspnea and/or physical disabilities in an age-dependent manner. Although previous studies suggested that oxidative stress plays a pathological role development no direct evidence has been documented so far. In order to investigate significance heart, we generated heart/muscle-specific manganese superoxide dismutase-deficient mice. The mutant mice developed progressive congestive failure with specific molecular...
Animal fetuses may be used for the regeneration of human organs. We have previously generated a transgenic mouse model that allows diphtheria toxin (DT)-induced ablation Six2-positive nephron progenitor cells (NPCs). Elimination existing native host NPCs enables their replacement with donor NPCs, which can generate neo-nephrons. However, this system cannot applied to because DT induces apoptosis in cells. Therefore, present study presents using tamoxifen, does not affect Using system, we...
Atrophy or hypofunction of the salivary gland because aging disease causes hyposalivation and has an effect on quality life patients, for example not only dry mouth but deterioration in mastication/deglutition disorder status oral hygiene. Currently conducted therapies atrophy clinical practice are symptomatic treatments with drugs artificial saliva, therefore it is preferable to establish a radical therapy. At this time, as fundamental investigation, by co-culturing mouse early ES (mEES-6)...
The effects of dexamethasone (DEX) on the onset GH expression in fetal rat pituitary gland were studied. Pregnant rats received oral administration DEX dissolved drinking water (25 mg/liter) for 40 h before killing days 16-19 pregnancy. number immunoreactive cells control fetus day 18 was very small, whereas it remarkably increased by to a compatible value obtained from fetuses 19. effect induction found be less potent 17 and not evident 16. population 19 doubled, they stained more intensely...
Expression of human protein kinase C delta (PKCδ) has been linked to many types cancers. PKCδ is known be a multifunctional PKC family member and rigorously studied as an intracellular signaling molecule. Here we show that secretory regulates cell growth liver cancer. Full-length was secreted the extracellular space in living cancer cells under normal culture conditions xenograft mouse models. Patients with showed higher levels serum than patients chronic hepatitis or cirrhosis healthy...
The regulation of growth hormone (GH) cell development by thyroid and glucocorticoid hormones in the fetal rat pituitary gland was examined. Dexamethasone (Dex) treatment dams induced GH mRNA accumulation on day 17 or 18 gestation when substantial expression has not yet occurred control fetus. additional thyroxine injections apparently enhanced effect Dex, whereas it exhibited no given alone. reduction level methimazole suppressed either Dex induction spontaneous onset 19 gestation. results...
Abstract Background Biallelic CLN3 gene variants have been found in either juvenile‐onset neuronal ceroid lipofuscinosis (JNCL) or isolated retinal dystrophy. It has reported that most JNCL patients carry a common 1.02‐kb deletion variant homozygously. Clinical characteristics of with biallelic missense are not well elucidated. Methods We described 26‐year‐old Japanese male patient Whole‐exome sequencing (WES) and transmission electron microscopy (TEM) were performed. Results identified...
Mucopolysaccharidosis type II is a disease caused by organ accumulation of glycosaminoglycans due to iduronate 2-sulfatase deficiency. This study investigated the pathophysiology bone complications associated with mucopolysaccharidosis and effect lentivirus-mediated gene therapy hematopoietic stem cells on lesions mouse models in comparison enzyme replacement therapy. Bone volume, density, strength, trabecular number were significantly higher untreated mice than wild-type mice. Accumulation...
Protein secretion in cancer cells defines tumor survival and progression by orchestrating the microenvironment. Studies suggest occurrence of active cytosolic proteins liver their involvement tumorigenesis. Here, we investigated identification extended-synaptotagmin 1 (E-Syt1), an endoplasmic reticulum (ER)-bound protein, as a key mediator for protein at ER-plasma membrane (PM) contact sites. Cytosolic interacted with E-Syt1 on ER, then localized spatially inside SEC22B+ vesicles cells....
We found that treatment with thiamine can have a protective effect on myocardial ischemia. Thiamine likely mediates mitochondrial fission through the inhibition of DRP1 phosphorylation and preservation larger-sized mitochondria ATP concentration, leading to higher cardiac contractility performance during subsequent reperfusion state.
96 male rats were tested in open field dim-light condition or bright-light for 3 min. per day 5 days. The validity of 7 open-field test measures was assessed on the basis concept which defined operationally using situation as external criterion. Ambulation first 1 and rearing showed not only but also some generality. An interactive measure (ambulation defecation) proposed a new significant measure. Larger intercorrelations among obtained less stressful situation. In view results, an...
Loss of podocytes is a common feature diabetic renal injury and key contributor to the development albuminuria. We found that podocyte Rho associated coiled-coil containing protein kinase 2 (ROCK2) activated in rodent models patients with diabetes. Mice lacked ROCK2 only (PR2KO) were resistant albuminuria, glomerular fibrosis, loss multiple animal diabetes (i.e., streptozotocin injection, db/db, high-fat diet feeding). RNA-sequencing ROCK2-null provided initial evidence suggesting as...
Increasing evidence suggests natriuretic peptides (NPs) coordinate interorgan metabolic crosstalk. We recently reported exogenous ANP treatment ameliorated systemic insulin resistance by inducing adipose tissue browning and attenuating hepatic steatosis in diet-induced obesity (DIO). herein investigated whether also ameliorates myocardial resistance, leading to cardioprotection during ischemia–reperfusion injury (IRI) DIO. Mice fed a high-fat diet (HFD) or normal-fat for 13 weeks were...