A5031050928- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Urologic and reproductive health conditions
- Urological Disorders and Treatments
- Renal and related cancers
- Testicular diseases and treatments
- Hormonal and reproductive studies
- MRI in cancer diagnosis
- Cancer, Lipids, and Metabolism
- Urinary Bladder and Prostate Research
- Radiopharmaceutical Chemistry and Applications
- Pediatric Urology and Nephrology Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- Multiple and Secondary Primary Cancers
- Urinary Tract Infections Management
- Colorectal Cancer Screening and Detection
- Cancer Immunotherapy and Biomarkers
- Neuroblastoma Research and Treatments
Saitama Medical University
2016-2025
Social Insurance Saitama Chuo Hospital
2016-2025
Kyushu Rosai Hospital
2023-2024
Kyushu Hospital
2013-2022
Kitakyushu Municipal Medical Center
2021
Asahi Kasei (Japan)
2012-2019
Hara Eye Hospital
2017-2018
Fukuda Denshi (Japan)
2016
Tokyo Metropolitan Institute of Gerontology
2003-2015
Tokyo Medical and Dental University
2004-2014
Elderly people insidiously manifest the symptoms of heart failure, such as dyspnea and/or physical disabilities in an age-dependent manner. Although previous studies suggested that oxidative stress plays a pathological role development no direct evidence has been documented so far. In order to investigate significance heart, we generated heart/muscle-specific manganese superoxide dismutase-deficient mice. The mutant mice developed progressive congestive failure with specific molecular...
Abstract Purpose: To determine the incidence of Xp11 translocation renal cell carcinoma (RCC) in adult patients using cytogenetics and immunohistochemstry. Experimental Design: Cytogenetic studies were prospectively done tumor samples from 443 consecutive Japanese (ages 15-89 years) who underwent nephrectomy for RCC. TFE3 immunohistochemistry was cases which cytogenetic results not obtained. Clinicopathologic characteristics RCC examined. Results: Mitotic cells suitable analysis obtained 244...
C-reactive protein has been shown to be a prognostic factor for renal cell carcinoma. We developed new prediction model including in patients with clear carcinoma.This study is based on 2 cohorts of Japanese carcinoma, 249 evaluating factors and developing the model, 290 external validation. Analyzed included TNM classification, tumor size, Fuhrman nuclear grade, necrosis preoperative serum (cutoff 0.5 mg/dl). scoring multivariate analysis predict cancer specific survival. Predictive ability...
No AccessJournal of UrologyAdult Urology1 Sep 2013High Diagnostic Ability Multiparametric Magnetic Resonance Imaging to Detect Anterior Prostate Cancer Missed by Transrectal 12-Core Biopsy Yoshinobu Komai, Noboru Numao, Soichiro Yoshida, Yoh Matsuoka, Yasukazu Nakanishi, Chikako Ishii, Fumitaka Koga, Kazutaka Saito, Hitoshi Masuda, Yasuhisa Fujii, Satoru Kawakami, and Kazunori Kihara KomaiYoshinobu Komai More articles this author , NumaoNoboru Numao YoshidaSoichiro Yoshida MatsuokaYoh...
The repeated-dose liver micronucleus (RDLMN) assay using young adult rats has the potential to detect hepatocarcinogens. We conducted a collaborative study assess performance of this and evaluate possibility integrating it into general toxicological studies. Twenty-four testing laboratories belonging Mammalian Mutagenicity Study Group, subgroup Japanese Environmental Mutagen Society, participated in trial. Twenty-two model chemicals, including some hepatocarcinogens, were tested 14- and/or...
We evaluated the usefulness of pre-biopsy multiparametric magnetic resonance imaging and clinical variables to decrease initial prostate biopsies.We prospectively 351 consecutive men with specific antigen between 2.5 20 ng/ml, and/or digital rectal examination suspicious for clinically localized disease. All underwent 14 29-core biopsy, including anterior sampling. Three definitions significant cancer were defined based on Gleason score volume (percent positive core maximum length). The...
To evaluate the accuracy of transvaginal ultrasound (US) and gadolinium-enhanced magnetic resonance (MR) imaging in assessment intratumoral structure an adnexal mass.The population comprised 82 patients with mass who underwent both US MR had surgical confirmation. The findings from modalities were compared retrospectively those surgery.The sensitivity, specificity, 100%, 98%, 99% 97%, 46%, 68% for identification solid tissue masses. Transvaginal exhibited many (n = 25) false-positive...
To assess the impact of preoperative C-reactive protein (CRP) levels on prognosis in patients with upper urinary tract (UUT) urothelial carcinoma (UC) primarily treated surgically, as it is increasingly recognized that a systemic inflammatory response associated for various malignancies.The clinical records 130 surgically UUT-UC were reviewed retrospectively. An elevated CRP was defined >0.5 mg/dL. Actuarial survival curves calculated by Kaplan-Meier method, difference between evaluated...
For metastatic bladder cancer patients, systemic cisplatin (CDDP)-based combination chemotherapy is the first-line choice of treatment. Although up to 70% advanced patients initially show good tumor response this form chemotherapy, over 90% responders relapse and eventually die disease. According stem cell theory, phenomenon attributable re-growth cancer-initiating cells (BCICs) that have survived chemotherapy. In study, authors isolated BCICs from cultured human analyze their sensitivity...
The aim of the present study was to evaluate diffusion-weighted (DW) magnetic resonance imaging (MRI) in differentiating between minimal fat angiomyolipoma (MFAML) and clear cell renal carcinoma (CCRCC). Forty-one solid tumors without visible macroscopic on unenhanced computed tomography images were evaluated by MRI, including DW-MRI, diagnosed pathologically as CCRCC (n = 36) or MFAML 5). To heterogeneity diffusion each tumor, signals DW-MRI analyzed subjectively apparent coefficient (ADC)...
To evaluate oncological outcomes of muscle-invasive bladder cancer (MIBC) patients who were treated with a selective bladder-sparing protocol consisting induction low-dose chemoradiotherapy (LCRT) plus partial cystectomy (PC) pelvic lymph node dissection.From 1997-2010, 183 consecutive cT2-4aN0M0 (median age 70 years, women/men = 46/137, T2/3/4a 100/69/14) underwent debulking transurethral resection followed by LCRT (radiation at 40 Gy to the small pelvis concurrently two cycles i.v....
Abstract Purpose: The phase III PROfound study (NCT02987543) evaluated olaparib versus abiraterone or enzalutamide (control) in metastatic castration-resistant prostate cancer (mCRPC) with tumor homologous recombination repair (HRR) gene alterations. We present exploratory analyses on the use of circulating DNA (ctDNA) testing as an additional method to identify patients mCRPC HRR alterations who may be eligible for treatment. Patients and Methods: Plasma samples collected during screening...
We have previously reported the expression of aquaporin-7 (AQP7) in rat testis and cloned human AQP7 from testicular cDNA library. However, to our knowledge spatial pattern biological roles remain be elucidated humans.We investigated ejaculated sperm fertile men infertile patients.AQP7 was expressed at tail spermatids spermatozoa testis. protein also detected middle piece anterior tale portion sperm. some patients lacked sperm, although all protein. The motility rate negative significantly...