A5031031334- Neutrino Physics Research
- Particle physics theoretical and experimental studies
- Radiation Detection and Scintillator Technologies
- Atomic and Subatomic Physics Research
- Astrophysics and Cosmic Phenomena
- Dark Matter and Cosmic Phenomena
- Particle Detector Development and Performance
- Medical Imaging Techniques and Applications
- Carcinogens and Genotoxicity Assessment
- Pregnancy and preeclampsia studies
- Radiation Effects in Electronics
- Effects and risks of endocrine disrupting chemicals
- Nuclear physics research studies
- Reproductive System and Pregnancy
- Nuclear Physics and Applications
- DNA Repair Mechanisms
- Radiation Therapy and Dosimetry
- Birth, Development, and Health
- Astronomical Observations and Instrumentation
- Laser Design and Applications
- Prenatal Substance Exposure Effects
- Advanced Memory and Neural Computing
- Cancer Risks and Factors
- Genetically Modified Organisms Research
- Acute Lymphoblastic Leukemia research
University of Fukui
2015-2024
Fukui University of Technology
2013-2024
Osaka University
2007-2022
Tohoku University
2008-2020
Tokyo University of Science
2020
The University of Tokyo
2020
Miyagi University of Education
2020
Nissan Chemical Corporation (Japan)
2006-2015
Tokushima University
2011
Saga University
2002-2011
The placenta grows rapidly for a short period with high blood flow during pregnancy and has multifaceted functions, such as its barrier function, nutritional transport, drug metabolizing activity endocrine action. Consequently, the is highly susceptible target organ drug- or chemical-induced adverse effects, many placenta-toxic agents have been reported. However, histopathological examination of not generally performed, placental toxicity index only weight change in rat reproductive studies....
The repeated-dose liver micronucleus (RDLMN) assay using young adult rats has the potential to detect hepatocarcinogens. We conducted a collaborative study assess performance of this and evaluate possibility integrating it into general toxicological studies. Twenty-four testing laboratories belonging Mammalian Mutagenicity Study Group, subgroup Japanese Environmental Mutagen Society, participated in trial. Twenty-two model chemicals, including some hepatocarcinogens, were tested 14- and/or...
The partial hepatectomy method, co-treatment method with mitogens and an in vivo/in vitro assay have been reported as vivo liver micronucleus (MN) assays. These methods disadvantages respect to widespread use assay, i.e. they are time consuming, labour intensive there is the possibility of interaction used. Therefore, we attempted develop a new overcome these disadvantages. described herein utilises autonomous proliferation hepatocytes young rats. Nine chemicals evaluated using this thus...
We searched for the neutrino-less double-$\ensuremath{\beta}$ decay($0\ensuremath{\nu}\ensuremath{\beta}\ensuremath{\beta}$) of $^{48}\mathrm{Ca}$ by using ${\mathrm{CaF}}_{2}$(Eu) scintillators. Analysis their pulse shapes was effective to reduce backgrounds. No events are observed in ${Q}_{\ensuremath{\beta}\ensuremath{\beta}}$ value region data 3394 kg \ifmmode\cdot\else\textperiodcentered\fi{} day. It gives a lower limit (90% confidence level)...
Achieving direct imaging of the annihilation position a positron on an event-by-event basis using ultrafast detector would have great impact field nuclear medicine. Cherenkov emission is most attractive physical phenomenon for realizing such timing performance. Moreover, microchannel-plate photomultiplier tube (MCP-PMT) one promising photodetectors fully exploiting fast properties owing to its excellent single photon time resolution 25 ps full width at half maximum (FWHM). However, as MCP...
We developed a CANDLES-III system to study the neutrino-less double beta (0$\nu\beta\beta$) decay of $^{48}$Ca. The proposed employs 96 CaF$_{2}$ scintillation crystals (305 kg) with natural Ca ($^{\rm nat.}$Ca) isotope which corresponds 350\,g External backgrounds were rejected using 4$\pi$ active shield liquid scintillator surrounding CaF$_2$ crystals. internal caused by radioactive impurities within can be reduced effectively through analysis signal pulse shape. analyzed data obtained in...
Indole-3-acetic acid (IAA), known as natural auxin, induces cleft palate in rodents. However, there has been no report about the neurodevelopmental toxicity of IAA rats. In present study, we found microencephaly fetuses from rats exposed to IAA. The purpose this work was examine effects administration pregnant on neuroepithelial cells embryos/fetuses. administered at 500 and 1,000 mg/kg gestation days (days) 12, 13, 14, then embryos/fetuses were harvested 14.5, 15, 16, 21. Cleft induced...
The observation of neutrino-less double beta decay (0vßß) would be the most practical way to prove Majorana nature neutrino and lepton number violation. CANDLES studies 48Ca using CaF2 scintillator. main advantage is that it has highest Q-value (4.27 MeV) among all isotope candidates for 0vßß.
Abstract CANDLES(CAlcium fluoride for the study of Neutrinos and Dark matters by Low Energy Spectrometer) is experiment to search neutrino-less double beta decay(0 vββ ) 48 Ca with CaF 2 scintillator. has highest Q ββ -value (4.3 MeV) among all isotope candidates 0 . It enables us measure signals very low background condition. After rejection analysis 131 days × 86 kg data events from radioactive contaminations in scintillators, no are observed region. As a result, half-life greater than 6.2...
In order to investigate the morphological effects of ketoconazole on hypertrophied placentas, we examined sequential histopathological changes in placenta from rats exposed ketoconazole. Ketoconazole was administered orally at 0 and 25 mg/kg/day during gestation days (GDs) 12 14, placentas were sampled GDs 15, 17 21. All dams showed neither effect body weight nor any abnormal clinical signs experimental period. treated group, appeared more hypertrophic with increases weight, diameter...
CANDLES is the project to search for neutrinoless double beta(0νββ) decay of 48Ca by using CaF2 scintillators. The observation 0νββ will prove existence a massive Majorana neutrino. expected performances system lightsignal detection and background rejection are presented here. current status development detector also described.
In order to investigate the toxic effects of 6-mercaptopurine (6-MP) on placental development, we examined sequential morphology in placentas from rats exposed 6-MP. 6-MP was intraperitoneally administered at 60 mg/kg during gestation days (GDs) 11 12, and were sampled GD 13, 15 or 21. 6-MP-treated group, maternal body weight suppression, increased death embryo/fetus ratio some malformations observed. The placenta weights decreased GDs Macroscopically, 21 small, brittle thin with a white...