A5064683515- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Enzyme function and inhibition
- Lung Cancer Treatments and Mutations
- Urinary and Genital Oncology Studies
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Heat shock proteins research
- Urological Disorders and Treatments
- Multiple and Secondary Primary Cancers
- Renal and related cancers
- Cancer, Lipids, and Metabolism
- Chemical Reactions and Isotopes
- Urinary Tract Infections Management
- Radiomics and Machine Learning in Medical Imaging
- Surgical Simulation and Training
- Ferroptosis and cancer prognosis
- Urologic and reproductive health conditions
- Surgical site infection prevention
- MRI in cancer diagnosis
- Biochemical and Molecular Research
- ATP Synthase and ATPases Research
- Colorectal Cancer Surgical Treatments
- Urinary Bladder and Prostate Research
- Palliative Care and End-of-Life Issues
Saiseikai Utsunomiya hospital
2023
Tokyo Medical and Dental University
2008-2015
Center for Cancer Research
2013-2015
National Cancer Institute
2013-2015
National Institutes of Health
2015
SUNY Upstate Medical University
2013
Cancer Research Institute
2013
Hokkaido University
2013
Vanderbilt University
2013
Tsuchiura Kyodo General Hospital
2008
Significance TNF receptor-associated protein (TRAP1) is found predominantly in mitochondria. A possible direct impact of TRAP1 on mitochondrial metabolism remains unexplored. We used TRAP1-null cells and transient silencing/overexpression to show that regulates a metabolic switch between oxidative phosphorylation aerobic glycolysis immortalized mouse fibroblasts human tumor cells. deficiency promotes increased respiration, fatty acid oxidation, tricarboxylic cycle intermediates, ATP reactive...
For metastatic bladder cancer patients, systemic cisplatin (CDDP)-based combination chemotherapy is the first-line choice of treatment. Although up to 70% advanced patients initially show good tumor response this form chemotherapy, over 90% responders relapse and eventually die disease. According stem cell theory, phenomenon attributable re-growth cancer-initiating cells (BCICs) that have survived chemotherapy. In study, authors isolated BCICs from cultured human analyze their sensitivity...
The proto-oncogene MET is aberrantly activated via overexpression or mutation in numerous cancers, making it a prime anticancer molecular target. However, the clinical success of MET-directed tyrosine kinase inhibitors (TKI) has been limited due, part, to mutations domain that confer therapeutic resistance. Circumventing this problem remains key challenge improving durable responses patients receiving MET-targeted therapy. an HSP90-dependent kinase, and report we show HSP90 preferentially...
The two cytosolic/nuclear isoforms of the molecular chaperone HSP90, stress-inducible HSP90α and constitutively expressed HSP90β, fold, assemble maintain three-dimensional structure numerous client proteins. Because many HSP90 clients are important in cancer, several inhibitors have been evaluated clinic. However, little is known concerning possible unique isoform or conformational preferences either individual inhibitors. In this report, we compare relative interaction strength both HSP90β...
No AccessJournal of UrologyAdult Urology1 Aug 2008Prognostic Impact Postoperative C-Reactive Protein Level in Patients With Metastatic Renal Cell Carcinoma Undergoing Cytoreductive Nephrectomyis accompanied byRenal Masses—To Treat or Not to Treat? If That is the Question are Contemporary Biomarkers Answer?Allelic Loss Analysis Tumor Suppressor Genes Regardless Heterozygosity: von Hippel-Lindau Gene CarcinomaPharmacological Inhibitor Fatty Acid Synthase Suppresses Growth and Invasiveness...
Radical cystectomy for muscle-invasive bladder cancer (MIBC) patients frequently impairs their quality of life (QOL) due to urinary diversion. To improve QOL, a bladder-sparing alternative strategy using chemoradiation has been developed. In protocols, complete response (CR) induction is prerequisite preservation and favorable survival. Thus predicting resistance overcoming it would increase individual MIBC patients' chances preservation. The aim this study investigate putative molecular...
Objectives To describe the technical aspects of gasless laparoendoscopic single‐port clampless sutureless partial nephrectomy for peripheral renal tumors, and to evaluate its outcomes, including surgical, pathological, short‐term oncological functional outcomes. Methods Between January 2010 June 2013, 103 patients with tumors suggestive cell carcinoma underwent nephrectomy. In all cases, an attempt was made accomplish without vascular clamping using ultrasonic coagulating bipolar sealing...
We have recently reported favorable responses to a combination treatment comprising cimetidine, cyclooxygenase-2 inhibitor and renin-angiotensin-system in metastatic renal cell carcinoma (RCC). In view of the potential synergistic effects these three agents interferon-α (I-CCA therapy), we conducted phase-II trial examine efficacy toxicity I-CCA as first-line treatment. Fifty-one patients with advanced RCC received natural (3-6 million U thrice/week) cimetidine (800 mg), meloxicam (10...
Although radical cystectomy with urinary diversion is the standard treatment for muscle-invasive bladder cancer (MIBC), loss of native frequently impairs patient's quality life (QOL). Bladder-sparing approach incorporating chemoradiotherapy (CRT) improves QOL while not compromising survival outcomes in MIBC patients. In this approach, complete response to induction CRT a prerequisite preservation and favorable oncological outcomes. We investigated strategy potentiate cells by using Hsp90...
Abstract: We report a case of man with testicular cancer metastatic to the lung and retroperitoneal lymph node, significant elevation serum levels human chorionic gonadotropin, 534 000 mIU/mL. Just after initiation chemotherapy, life‐threatening hemothorax occurred hemorrhagic shock ensued. The pulmonary tumor had broken off, lower lobectomy was carried out. Pathologic examination specimen revealed choriocarcinoma yolk sac tumor. Through multimodal treatments he achieved complete remission....
Zoledronic acid (ZOL), a third-generation bisphosphonate that strongly inhibits osteoclast activity, is widely used for the treatment of bone metastasis from variety malignancies, including renal cell carcinoma (RCC). We previously reported zoledronic (ZOL) clinically potentiates antitumor effects radiotherapy (RT) on metastases RCC. To date, however, it remains unknown whether ZOL radiosensitizes RCC and if does, how. Here, we demonstrated directly cells independent activity by potentiating...
ObjectiveTo investigate the associations of diabetes mellitus with recurrence and prognosis after surgery for non-metastatic renal cell carcinoma effect modification obesity on above relationships.
Abstract Background To eradicate hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) using a stepwise infection control strategy that includes an avoidance of antimicrobial prophylaxis (AMP) based on surgical wound classification and improvement in operative procedures gasless single-port urologic surgery. Methods The study was conducted at 801-bed university hospital. Since 2001, the urology ward, we have introduced strategy. In 2007, surveillance cultures for MRSA all...
We report the effectiveness of a combination chemotherapy consisting ifosfamide, 5-fluorouracil, etoposide and cisplatin (IFEP chemotherapy) against metastatic adenocarcinoma urachus. From April 1995 to November 2004, four patients with urachus who developed metastases after definitive surgery were treated IFEP followed by consolidative radiotherapy or salvage in good responders. During median follow-up period 26 months, three responded regimen (75%). In one patient pulmonary metastases,...
As a result of the dramatic improvements in resolution, wearability, and weight head-mounted displays (HMDs), they have become increasingly applied medical field as personal imaging monitors. The combined use multiplexer with an HMD allows wearer to simultaneously seamlessly monitor multiple streams information through HMD. We developed multitask for surgical navigation by combining touchless control system This is composed standard color digital video camera mounted on computer software...
Objectives: To examine whether history of malignancy adds any significant information to the prediction positive prostate biopsy in referred men with moderately elevated prostate‐specific antigen (PSA) and develop a predicting nomogram that does not require extra examinations other than PSA. Methods: A total 1767 consecutive Japanese PSA less 10 ng/mL who underwent were included study cohort. Age, digital rectal examination (DRE), PSA, body mass index, family cancer number previous...
Abstract: We report three cases of metastatic renal cell carcinoma (RCC) in which combination treatment cimetidine, cyclooxygenase‐2 inhibitor and renin‐angiotensin system (angiotensin converting enzyme or angiotensin II type 1 receptor antagonist) (CCA therapy) was effective. Case 1: A 47‐year‐old man who had a 12‐cm right tumor with multiple pulmonary hepatic metastases refused cytokine therapy for economic reasons received CCA therapy. All the showed partial remission, continued 12...