A5080083665- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Adipose Tissue and Metabolism
- Cardiac Structural Anomalies and Repair
- Gout, Hyperuricemia, Uric Acid
- Diabetes Treatment and Management
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Cardiovascular Disease and Adiposity
- Cardiac Ischemia and Reperfusion
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Liver Disease Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Atrial Fibrillation Management and Outcomes
- Nitric Oxide and Endothelin Effects
- Cardiac Imaging and Diagnostics
- Alcohol Consumption and Health Effects
- Cardiac Arrest and Resuscitation
- Diet and metabolism studies
- Esophageal and GI Pathology
- Neuropeptides and Animal Physiology
- GDF15 and Related Biomarkers
- Metabolism, Diabetes, and Cancer
Jikei University School of Medicine
2010-2024
Toho University
2015-2023
Toho University Medical Center Sakura Hospital
2015-2023
Nihon University
1961-2016
Jikei University Kashiwa hospital
2010-2015
National Hospital Organization
2012-2013
National Disaster Medical Center
2012-2013
Kennesaw State University
2012
Recent large-scale clinical trials have shown that SGLT2-inhibitors reduce cardiovascular events in diabetic patients. However, the regulation and functional role of cardiac sodium–glucose cotransporter (SGLT1 is dominant isoform) compared with those other glucose transporters (insulin-dependent GLUT4 major remain incompletely understood. Given an important preferential substrate for myocardial energy metabolism under conditions ischemia–reperfusion injury (IRI), we hypothesized SGLT1...
Abstract Increasing evidence suggests natriuretic peptides (NPs) coordinate inter-organ metabolic crosstalk with adipose tissues and play a critical role in energy metabolism. We recently reported A-type NP (ANP) raises intracellular temperature cultured adipocytes low-temperature-sensitive manner. herein investigated whether exogenous ANP-treatment exerts significant impact on vivo. Mice fed high-fat-diet (HFD) or normal-fat-diet (NFD) for 13 weeks were treated without ANP infusion...
Accumulating evidence indicates that high uric acid (UA) is strongly associated with obesity and metabolic syndrome drives the development of nonalcoholic fatty liver disease (NAFLD) insulin resistance. Although urate transporter-1 (URAT1), which primarily expressed in kidneys, plays a critical role hyperuricemia, its pathophysiological implication NAFLD resistance remains unclear. We herein investigated functional significance URAT1 diet-induced obese mice. Mice fed high-fat diet (HFD) for...
Abstract In addition to the various effects of natriuretic peptides (NPs) on cardiovascular systems, increasing attention is being paid possibility that NPs induce adipose tissue browning and activate thermogenic program. We herein established a direct intracellular temperature measurement system using fluorescent thermoprobe investigated A-type NP (ANP) brown adipocytes. The was successfully introduced into rat adipocytes, dependent change in fluorescence intensity ratio measured...
High serum uric acid (UA) level has been assumed to be a risk factor for left ventricular (LV) dysfunction; however, the precise relationship between these conditions not fully examined because many confounding factors are associated with UA level. We herein by proposing structural equation models. The study population consisted of 1432 cases ischemic heart disease who underwent cardiac catheterization. Multiple regression analyses and covariance structure were performed elucidate...
Background: The aim of the present study was to assess long-term graft patency rate radial artery (RA), in comparison saphenous vein (SV) patients harvested for both vessels. Methods and Results: RA SV were concomitantly used coronary bypass grafting 318 an 8-year period from January 2002 March 2010. During follow-up, assessed on angiography or multi-slice computed tomography 192 these patients. Cumulative rates compared between SV. Independent predictors failure examined at 8 years 74.3%...
In patients with cardiovascular disorders, blood total ketone body (TKB) levels increase worsening heart failure and are consumed as an alternative fuel to fatty acid glucose. We investigated factors contributing the in TKB disorders. The study population consisted of 1030 consecutive who underwent cardiac catheterization. Covariance structure analyses were performed clarify direct contribution hemodynamic parameters, including left ventricular end-diastolic pressure (LVEDP), end-systolic...
We recently reported that the selective inhibition of urate transporter-1 (URAT1), which is primarily expressed in kidneys, ameliorates insulin resistance by attenuating hepatic steatosis and improving brown adipose tissue function diet-induced obesity. In this study, we evaluated effects dotinurad, a URAT1-selective inhibitor, on hearts high-fat diet (HFD)-fed obese mice for 16-20 weeks neonatal rat cardiomyocytes (NRCMs) exposed to palmitic acid. Outside URAT1 was also indeed worked as...
The US Food and Drug Administration has suggested that proton pump inhibitors (PPIs) increase the international normalized ratio (INR) when used concomitantly with warfarin (WF) because of being metabolized by cytochrome P450 2C19 (CYP2C19). We assessed whether CYP2C19 genotypes type PPI accentuated drug interaction.The study group was 82 patients who needed WF after surgery had their analyzed in advance. randomly divided them into two groups: I (n = 41) included lansoprazole 15 mg/day II...
Increasing evidence suggests natriuretic peptides (NPs) coordinate interorgan metabolic crosstalk. We recently reported exogenous ANP treatment ameliorated systemic insulin resistance by inducing adipose tissue browning and attenuating hepatic steatosis in diet-induced obesity (DIO). herein investigated whether also ameliorates myocardial resistance, leading to cardioprotection during ischemia–reperfusion injury (IRI) DIO. Mice fed a high-fat diet (HFD) or normal-fat for 13 weeks were...
Although glucose-insulin-potassium (GIK) therapy ought to be beneficial for ischemic heart disease in general, variable outcomes many clinical trials of GIK acute coronary syndrome (ACS) had a controversial impact. This study was designed examine whether "insulin resistance" is involved ACS and clarify other potential intrinsic compensatory mechanisms tolerance through highly statistical procedure.We compared the degree insulin resistance during attack remission phase after treatment...
Abstract Aims Although the haemodynamic effects of angiotensin receptor‐neprilysin inhibitor (ARNI) on patients with heart failure have been demonstrated, effect glucose metabolism has not fully elucidated. We retrospectively investigated ARNI abnormal in stable chronic using an additional structural equation model (SEM) analysis. Methods analysed 34 who regularly visited to outpatient department our institute from October 2021 and July 2022 were taking angiotensin‐converting enzyme (ACE)...
Abstract Glucose is an important preferential substrate for energy metabolism during acute coronary syndrome (ACS) attack, although insulin resistance (IR) increases ACS. Increasing evidence indicates that natriuretic peptides (NP) regulate glucose homeostasis. We investigated possible compensatory actions of NP in collaboration with other neurohumoral factors facilitate utilization The study population consisted 1072 consecutive cases ischemic heart disease who underwent cardiac...
In the emergency department, it is sometimes difficult to differentiate heart failure (HF) from other diseases (e.g., respiratory diseases) in patients who develop dyspnea. The plasma B-type natriuretic peptide (BNP) levels increase with HF, and various are associated specific New York Heart Association classes. Although diagnosis of HF should not be made based only on BNP levels, identification a cut-off value for diagnose would helpful.Patients admitted department our hospital dyspnea...
This study aims to measure the solid−liquid equilibria (SLE) of systems containing diphenyl carbonate (DPC) for production high-purity DPC as required a nonphosgene-based polycarbonate process. SLE data three binary systems: methanol + DPC, dimethyl (DMC) and phenol were determined at atmospheric pressure by visually observing melting points wide range compositions. An experimental apparatus allow both accurate control temperature visual observation was designed this study, procedure...
Abstract Natriuretic peptides (NPs) regulate blood pressure and fluid homeostasis exert various effects on the cardiovascular system. Recently, relationship between NPs energy metabolism has been reported, using a cell culture experiment system, we previously showed that NP activated brown cells in low temperature environment while also suppressing decrease temperature. However, few reports have described secretion of cold environments, there almost no studies B-type natriuretic peptide...
Thyroid hormone metabolism can be closely associated with cardiovascular disorders. We examined the relationship between low triiodothyronine (T3) levels and heart failure status, including B-type natriuretic peptide (BNP) levels, in 625 patients disorders who underwent cardiac catheterization. A multiple regression analysis revealed that left ventricular ejection fraction (LVEF), hemoglobin (Hb) sex (male), free T3 (FT3) estimated glomerular filtration rate (eGFR) were significantly...
We present a case of an aortocaval fistula without bleeding because clot was covering the fistula. A 60-year-old man diagnosed as having ruptured abdominal aortic aneurysm and fistula, by enhanced computed tomography. After had been opened, detected, but there no it covered with clot. graft repair, from occurred when removed suction. Direct closure achieved after controlled digital compression.
A 54-year-old man presented with neck pain and hoarseness. Angiography showed a rare right subclavian artery aneurysm, enlargement of the ascending aortic axillary stenosis. These aneurysms would normally be treated end-to-end anastomosis, but due to complexity lesion in this case, we performed more extensive surgery. This consisted successful reconstruction replacement aorta arch.