A5081476802- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Renal cell carcinoma treatment
- Genomic variations and chromosomal abnormalities
- RNA modifications and cancer
- Endometriosis Research and Treatment
- Cancer Genomics and Diagnostics
- Intraperitoneal and Appendiceal Malignancies
- Cervical Cancer and HPV Research
- Radiomics and Machine Learning in Medical Imaging
- PARP inhibition in cancer therapy
- Cancer-related Molecular Pathways
- Colorectal and Anal Carcinomas
- Uterine Myomas and Treatments
- Nutrition, Genetics, and Disease
- Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Chromatin Remodeling and Cancer
- Cancer, Lipids, and Metabolism
- Microtubule and mitosis dynamics
- Lung Cancer Research Studies
- Galectins and Cancer Biology
- Lymphatic System and Diseases
- Reproductive Biology and Fertility
- Cholangiocarcinoma and Gallbladder Cancer Studies
Jikei University School of Medicine
2015-2025
Jikei University Kashiwa hospital
2016-2025
University of California, San Francisco
2023
UCSF Helen Diller Family Comprehensive Cancer Center
2023
Katsushika Medical Center
2022
Abstract Purpose: This study was designed to elucidate the role of amplification at 8q24 in pathophysiology ovarian and breast cancer because increased copy number this locus is one most frequent genomic abnormalities these cancers. Experimental Design: To accomplish this, we assessed association with outcome cancers using fluorescence situ hybridization tissue microarrays measured responses cell lines specific small interfering RNAs against oncogene MYC a putative noncoding RNA, PVT1, both...
We aimed to develop an ovarian cancer-specific predictive framework for clinical stage, histotype, residual tumor burden, and prognosis using machine learning methods based on multiple biomarkers.Overall, 334 patients with epithelial cancer (EOC) 101 benign tumors were randomly assigned "training" "test" cohorts. Seven supervised classifiers, including Gradient Boosting Machine (GBM), Support Vector Machine, Random Forest (RF), Conditional RF (CRF), Naïve Bayes, Neural Network, Elastic Net,...
This phase III, multicenter, randomized, open-label study investigated the efficacy and safety of nivolumab versus chemotherapy (gemcitabine [GEM] or pegylated liposomal doxorubicin [PLD]) in patients with platinum-resistant ovarian cancer.
This was the first large-scale prospective observational Japanese study evaluating safety and efficacy of bevacizumab combined with paclitaxel carboplatin for newly diagnosed advanced ovarian cancer. Patients were prospectively enrolled in primary analysis cohort if they had Stage III or IV epithelial ovarian/fallopian tube/primary peritoneal cancer scheduled to receive plus every 3 weeks Cycles 1–6 2–22. Primary endpoints bevacizumab-specific adverse events ≥ Grade 3. Secondary...
Advanced ovarian clear cell carcinoma (OCCC) is associated with poor outcomes owing to chemoresistance. Bevacizumab (Bev) increasingly being used treat advanced cancer; however, its efficacy in OCCC remains unclear. This study evaluated the treatment of frontline bevacizumab chemotherapy patients OCCC. retrospective multi-institutional included diagnosed at eight institutions Japan between 2008 and 2018. Patients were categorized into pre post-market groups based on Bev approval dates....
Human epididymis protein 4 (HE4) levels and the Risk of Ovarian Malignancy Algorithm (ROMA) have recently been shown to improve sensitivity specificity epithelial ovarian cancer (EOC) diagnosis. We evaluated HE4 ROMA as diagnostic tools type I II EOC in Japanese women. Women who had a pelvic mass on imaging were scheduled undergo surgery enrolled patients. Serum carbohydrate antigen 125 (CA125) tested 319 women (131 benign, 19 borderline, 75 malignant, 94 healthy controls). CA125, HE4, for...
Abstract Purpose: Although ovarian clear cell carcinomas (OCCC) are commonly resistant to platinum-based chemotherapy, good clinical outcomes observed in a subset of patients. The explanation for this is unknown but may be due misclassification high-grade serous cancer (HGSOC) as OCCC or mixed histology. Experimental Design: To discover potential biomarkers survival benefit following we ascertained cohort 68 Japanese and Australian patients whom progression-free (PFS) overall (OS) could...
The aim of the study is to investigate recurrence stage I epithelial ovarian cancer.Six hundred two patients diagnosed with cancer at 4 hospitals between 2000 and 2013 were retrospectively analyzed. Age, surgical procedure, substage, histologic type, adjuvant chemotherapy, recurrence, initial site (peritoneal dissemination [P], hematogenous [H], lymphogenous [L], others [O]), frequency each investigated retrospectively.Median age was 54 years median follow-up 60 months. IA in 180 cases...
This study compared the effectiveness, safety, and tolerability of dose-dense paclitaxel carboplatin plus bevacizumab (ddTC+Bev) with ddTC for advanced ovarian cancer.
// Asuka Morikawa 1, 2 , Tomoatsu Hayashi 1 Naomi Shimizu Mana Kobayashi Kenzui Taniue Akiko Takahashi Kota Tachibana Misato Saito Ayako Kawabata Yasushi Iida Kazu Ueda Motoaki Nozomu Yanaihara Hiroshi Tanabe 3 Kyosuke Yamada Hirokuni Takano Osamu Nureki 4 Aikou Okamoto and Tetsu Akiyama Laboratory of Molecular Genetic Information, Institute Cellular Biosciences, The University Tokyo, Japan Department Obstetrics Gynecology, Jikei School Medicine, University, Kashiwa Hospital, Chiba,...
5502 Background: Advanced ovarian clear cell carcinoma (ACCC, stage III/IV disease) is a rare tumor characterized by chemoresistance. Bevacizumab (Bev) was approved in November 2013 Japan and became incorporated the treatment of advanced cancer. However, efficacy Bev against ACCC remain unknown. We investigated survival outcomes for ACCC, following first-line chemotherapy with or without Bev. Methods: Patients diagnosed at seven institutions between 2008 2018 were enrolled this study....
Liquid-based cytology (LBC) and conventional (CS) are routine diagnostic techniques in cervical cytology, but few studies have compared their performances with each other histologic diagnosis. This study aimed to compare the of these subjects abnormal atypical cells undetermined significance (ASC-US) or worse.A total 312 patients diagnosed ASC-US worse were enrolled this prospective Japan from 2013 2014. LBC CS samples prepared by a split-sampling technique evaluated blindly. The results...
Since there have been few large series studies to date, we investigated the relationship between Trousseau's syndrome associated with cerebral infarction and its clinical associations ovarian cancer.In this study, association onset cancer. Eight-hundred twenty-seven consecutive cancer patients from 4 affiliated academic institutions were included in study over a 12 years period. All histopathologically diagnosed as epithelial analyzed retrospectively.The 27 (3.2%) presented during period, 14...
Patients with adeno/adenosquamous carcinoma may have a poorer prognosis than patients squamous cell carcinoma. Radiotherapy and concurrent chemoradiotherapy are used as adjuvant therapies for cervical cancer, regardless of the histological subtype. The aim this study was to investigate prognostic outcome therapy pathological risk factors. medical records 135 stage IB–IIB cancer or who underwent primary surgery followed by were retrospectively reviewed. pathologically confirmed bulky tumor...
Background: Endometriosis-associated ovarian cancer (EAOC) is a well-known type of that arises from endometrioma (OE). OE contains iron-rich fluid in its cysts due to repeated hemorrhages the ovaries. However, distinguishing between benign and malignant tumors can be challenging. We conducted retrospective study on magnetic resonance (MR) relaxometry cyst distinguish EAOC reported this method showed good accuracy. The purpose evaluate accuracy non-invasive re-evaluating pre-surgical...
Background Adult-type granulosa cell tumors of the ovary (aGCTs) are rare that represent 2–5% ovarian malignancies. The prognosis this tumor is favorable, and it characterized by slow progression. 10–30% these recur after 4–7 years primary surgery 5-year survival rate from first recurrence 55%, for incompletely resected patients. At time, complete resection only prognostic factor better outcome, establishing a novel strategy identification and/or treatment recurrent crucial. After discovery...
Lymphedema in lower limb is one of major postoperative complications followed by a total hysterectomy with lymph node dissection. The objective this report to examine long-term result lymphaticovenous anastomosis procedure as preventive surgery.Sixteen patients endometrial cancer underwent an abdominal bilateral salpingo-oophorectomy. Just after pelvic dissection, either end-to-end or sleeve utilizing venules and suprainguinal vessels was performed. During the observation period from 4 13...
5532 Background: The standard surgery for Stage IB1 uterine cervical cancer is radical hysterectomy (RH, Piver class III hysterectomy). However, RH highly invasive, and there a need to establish less invasive techniques. We conducted single-arm confirmatory trial (JCOG1101) evaluate the efficacy safety of modified (MRH) in patients with tumor diameter ≤ 2 cm (jRCT: jRCTs031180167). Methods: From January 2013 August 2017, 240 were enrolled from 40 institutions Japan. Eligibility criteria...
Hypersensitivity reactions (HSRs) to carboplatin, a key drug for ovarian cancer patients, are problematic. The aim of this study was evaluate the efficacy and safety readministration platinum agents (PTs) in recurrent patients who developed HSRs carboplatin.Thirty-one with carboplatin were divided into those continued receive PTs following cycle (continuation group, n=24) whom either switched non-platinum (non-PTs) or chemotherapy ended (discontinuation n=7). Outcomes evaluated based on...