A5066806706- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Colorectal and Anal Carcinomas
- Endometriosis Research and Treatment
- Genital Health and Disease
- Cancer Risks and Factors
- Cancer and Skin Lesions
- Sarcoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Ectopic Pregnancy Diagnosis and Management
- Cancer Cells and Metastasis
- Gynecological conditions and treatments
- Hepatitis B Virus Studies
- Reproductive tract infections research
- Cancer Immunotherapy and Biomarkers
- Maternal and fetal healthcare
- Nausea and vomiting management
- MicroRNA in disease regulation
- Breast Lesions and Carcinomas
- Pregnancy-related medical research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
Kyushu University
2016-2025
Kyushu University Hospital
2003-2025
Qilu Hospital of Shandong University
2023
Tottori University
2023
University of Ulsan
2023
Asan Medical Center
2023
Ulsan College
2023
Keio University
2023
Jichi Medical University
2023
University College London
2023
To assess the efficacy of fertility-sparing treatment using medroxyprogesterone acetate (MPA) for endometrial carcinoma (EC) and atypical hyperplasia (AH) in young women.This multicenter prospective study was carried out at 16 institutions Japan. Twenty-eight patients having EC presumed stage IA 17 with AH younger than 40 years age were enrolled. All given a daily oral dose 600 mg MPA low-dose aspirin. This continued 26 weeks, as long responded. Histologic change tissue assessed 8 weeks...
Clear cell carcinoma of the uterine cervix is a rare subtype. We report case 14-year-old girl who presented with abnormal genital bleeding, 7 cm mass arising from cervix, and swollen right inguinal lymph nodes. Histological immunohistochemical examinations showed clear carcinoma. performed modified-radical hysterectomy, bilateral salpingo-oophorectomy, node biopsy, pelvic para-aortic diagnosed cervical cancer stage IVB (clear carcinoma, pT2bN2M1). administered...
BACKGROUND Nuclear expression of Y box-binding protein (YB-1), a member the DNA binding family, has been reported to be much more highly concentrated in cisplatin-resistant cell lines than their parental counterparts, suggesting an ability limit cisplatin sensitivity. Moreover, YB-1 plays key role P-glycoprotein expression. Because ovarian carcinoma traditionally treated with cisplatin-based chemotherapy, sensitivity tumors chemotherapy could reflect particular prognosis patients carcinoma....
This study examined factors that affected sentinel lymph node (SLN) identification of patients with endometrial cancer having a preoperative estimation low recurrent risk.
Background: A molecular classification of endometrial cancer was developed based on an analysis The Cancer Genome Atlas. In this classification, the group characterized by abnormal p53 immunohistochemical expression showed poorest prognosis. However, there may be no need to apply a in low-grade cancer. study, we investigated clinical significance Methods: We obtained nine frozen samples [low-grade with wild-type (EClop53wt group): n = 3, (EClop53ab and high-grade (EChi 3]. RNA sequencing...
This multi-center retrospective study aimed to clarify the characteristics, diagnostic accuracy, treatment outcomes, and prognostic factors of uterine serous carcinoma (USC) in Japanese women. The medical records 193 patients who were treated between 2006 2008 at 24 participating institutions Clinical Oncology Group examined, pathological slides 188 re-checked through central pathology review (CPR), hematoxylin-eosin staining, immunohistochemistry. USC was confirmed 144 (76.6%) using CPR,...
Abstract Aim Clear cell carcinoma of the uterine cervix (CCCUC) is a rare disease, accounting for 4% to 9% cervical adenocarcinomas. Because it so rare, its pathogenesis largely unknown, and standard treatment unclear due lack prospective studies. Our aim investigate clinical features, treatment, prognosis CCCUC. Methods We retrospectively evaluated characteristics, choices, outcomes 12 patients with CCCUC treated at our institution between January 2009 July 2024. Results The median patient...
The objective of our study was to evaluate the technical and clinical outcomes uterine artery embolization (UAE) along with administration methotrexate (MTX) for cervical ectopic pregnancy vaginal bleeding as an alternative nonsurgical treatment control preserve fertility.Eight patients (age range, 24-37 years; mean age, 30.1 years) were treated UAE using gelatin sponge particles bleeding. In seven patients, MTX performed before, after, or before after UAE. follow-up periods ranged from 4 46...
Abstract Background Although many human papillomavirus (HPV)–targeted therapeutic vaccines have been examined for efficacy in clinical trials, none translated into use. These previous agents were mostly administered by intramuscular or subcutaneous injection to induce systemic immunity. We investigated the safety and of an HPV-16 E7-expressing lacticaseibacillus-based oral vaccine. Methods In a double-blind, placebo-controlled, randomized trial, total 165 patients with HPV-16–positive...
Aims p16 is a sensitive surrogate marker for transcriptionally active high‐risk human papillomavirus (HR‐HPV) infection in endocervical adenocarcinoma (ECA); however, its specificity not perfect. Methods and results We examined Rb expressions by immunohistochemistry (IHC) the HR‐HPV mRNA in‐situ hybridisation (ISH) with histological review 108 ECA cases. Thirteen adenocarcinomas of endometrial or equivocal origin (six endometrioid seven serous carcinomas) were compared as control group. was...
Despite numerous reports on pregnancy outcomes after trachelectomy, there are few descriptions of fertility treatment trachelectomy. Moreover, little is known about the differences in between various radical trachelectomy procedures. The purpose this report was to clarify infertility problems that occur patients who have previously undergone an abdominal trachelectomy.We retrospectively investigated medical records 37 received treatments or were evaluated for menstrual disorders...
To obtain baseline data for cervical cancer prevention in Japan, we analyzed human papillomavirus (HPV) from 5045 Japanese women aged less than 40 years and diagnosed with abnormalities at 21 hospitals during 2012-2017. These included intraepithelial neoplasia grade 1 (CIN1, n = 573), CIN2-3 (n 3219), adenocarcinoma situ (AIS, 123), invasive (ICC, 1130). The Roche Linear Array was used HPV genotyping. type-specific relative contributions (RCs) were estimated by adding multiple infections to...
<b><i>Background and Objectives:</i></b> Trachelectomy, a fertility-sparing surgery for early-stage cervical cancer, can be performed only when there is no extrauterine extension present. Therefore, identifying the sentinel lymph nodes (SLNs) using them to obtain an intraoperative pathologic diagnosis provide information on feasibility safety of trachelectomy. Our aim was assess value SLN diagnosis. <b><i>Methods:</i></b> We retrospectively...
The prognosis of patients with high-grade or advanced-stage endometrial cancer remains poor. As stem-like cells (CSCs) are thought to be associated cancers, it is essential investigate the molecular mechanisms that regulate CSCs. Dual-specificity phosphatase 6 (DUSP6) functions as a negative-feedback regulator MAPK-ERK1/2 signaling, but its role in unknown. We investigated whether DUSP6 involved cell stemness using lines and specimens from patients. induced expression CSC-related genes...
Abstract Background Matricellular glycoprotein, SPARC is a secreted molecule, that mediates the interaction between cells and extracellular matrix. functions as regulator of matrix organization modulates cell behavior. In various kinds cancer, strong expression was observed in stromal tissues well cancer epithelial cells. The function somewhat controversial its impact on peritumoral remains to be resolved. Methods We investigated effects endometrial surrounding fibroblasts using vitro...
This is a concept paper of multicenter, placebo-controlled, double-blind randomized phase I/II trial to test the safety and efficacy IGMKK16E7 for patients with HPV16-positive high-grade squamous intraepithelial lesion.