A5075158215- Nitric Oxide and Endothelin Effects
- Uterine Myomas and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Agricultural Systems and Practices
- Gynecological conditions and treatments
- Clay minerals and soil interactions
- Atherosclerosis and Cardiovascular Diseases
- Renin-Angiotensin System Studies
- Geochemistry and Elemental Analysis
- Receptor Mechanisms and Signaling
- Protease and Inhibitor Mechanisms
- Ectopic Pregnancy Diagnosis and Management
- Endometrial and Cervical Cancer Treatments
- Cardiac Ischemia and Reperfusion
- Cardiac Imaging and Diagnostics
- Cardiovascular Effects of Exercise
- Signaling Pathways in Disease
- Cell Adhesion Molecules Research
- Female Genital Mutilation/Cutting Issues
- Cardiac Arrest and Resuscitation
- Lipoproteins and Cardiovascular Health
- Pancreatitis Pathology and Treatment
Kyushu University
2006-2024
Hamanomachi Hospital
2008-2024
Kyushu University Hospital
2019
Leiden University
2006
Amsterdam UMC Location University of Amsterdam
2006
Osaka University
2003
Dana (United States)
1991
Experimental Station
1990
BACKGROUND It has been suggested that endothelium-related vasomotion is important in the control of coronary circulation. Our goal was to determine if endothelium-dependent dilation vasculature altered with aging 18 patients atypical chest pain (age, 23-70 years) who had angiographically normal arteries and no risk factors. METHODS AND RESULTS We infused an vasodilator acetylcholine (1, 3, 10, 30 micrograms/min) endothelium-independent papaverine (10 mg) into left artery. The large diameter...
We examined whether coronary risk factors and atherosclerotic lesions in the study artery were associated with impaired endothelium-dependent dilation of resistance arteries. Acetylcholine (ACH) at graded doses (1, 3, 10 30 micrograms/min) papaverine (10 mg) selectively infused into left anterior descending 28 patients, whom was angiographically normal (n = 16) or mild stenosis < 40% 12). Coronary blood flow (CBF) estimated from product mean CBF velocity measured by an intracoronary Doppler...
The long-term administration of N(omega)-nitro-L-arginine methyl ester (L-NAME), an inhibitor nitric oxide synthesis, produces coronary vascular remodeling and myocardial hypertrophy in animals. This study used a rat model to investigate the role angiotensin I converting enzyme (ACE) pathogenesis such changes. We studied following groups, all which received drug treatment their drinking water: untreated controls, those administered L-NAME, ACE (ACEI), L-NAME hydralazine. Cardiovascular...
Studies in vitro have suggested that inflammatory cytokines may play an important role the pathogenesis of atherosclerosis. However, little is known about their effects vivo. Thus, present study was designed to determine vivo what histological and functional changes be induced by chronic treatment with IL-1 beta, one major cytokines, also clarify mechanisms are involved those changes. Under aseptic conditions, proximal segments left porcine coronary arteries were gently wrapped cotton mesh...
There is no effective treatment for women with unexplained recurrent pregnancy loss (RPL). We aimed to investigate whether a high dose of intravenous immunoglobulin (IVIG) in early can improve outcomes RPL.In double-blind, randomised, placebo-controlled trial, primary RPL aetiology received 400 mg/kg IVIG daily or placebo five consecutive days starting at 4-6 weeks gestation. They had experienced four more miscarriages except biochemical and least one miscarriage normal chromosome karyotype....
Because late vein graft failure is caused by intimal hyperplasia (IH) and accelerated atherosclerosis, these processes are thought to be inflammation driven, influx of monocytes one the first phenomena seen in IH, we would like provide direct evidence for a role MCP-1 pathway development disease.MCP-1 expression demonstrated various stages disease murine model which venous interpositions placed carotid arteries hypercholesterolemic ApoE3Leiden mice cultured human saphenous (HSV) segments IH...
Studies in vitro suggested that inflammatory cytokines could cause myocardial dysfunction. However, the detailed mechanism for cytokine-induced dysfunction vivo remains to be examined. We thus examined this point our new canine model vivo, which microspheres with and without IL-1beta were injected into left main coronary artery. Left ventricular ejection fraction (LVEF) was evaluated by echocardiography 1 wk. Immediately after microsphere injection, LVEF decreased approximately 30% both...
Endothelial dysfunction has been implicated as a cause of coronary vasospasm in patients with variant angina. This study aimed to determine if endothelium-dependent vasodilation evoked substance P (SP) was altered at the spastic site where induced by acetylcholine (ACH) It shown that SP evokes no direct effect on vascular smooth muscle excised human arteries. and ACH were infused into arteries nine angina whom arteriograms showed normal or mild atherosclerotic lesions. The vasomotor...
The pathogenesis of histamine-induced coronary spasm was examined angiographically and morphometrically in Göttingen miniature pigs. In five 36 consecutive pigs that were 4 to 5 months age, provoked by the intracoronary administration histamine, left arteries histologically without endothelial denudation (group 1). Endothelial balloon major branch artery performed 31 died during procedure. remaining 26 randomly allotted one two groups, fed a cholesterol-supplemented 2, n = 13) regular...
The mineralogy, geochemistry and geotechnical properties of clay samples in Ariake Bay, Japan are presented. mineralogy discussed terms depositional post-depositional processes, the correlations with were examined by multiple regression analysis. most predominant mineral deposits was found to be smectite. vertical distribution trace elements indicative periodical changes parent materials involved processes. chloride concentration pore water varied, according a change sea level, from brackish...
Mechanism of coronary spasm was examined regarding endothelium-related relaxation and contraction produced by smooth muscle cells spastic vessels isolated from Göttingen miniature pigs. In these pigs, artery documented angiographically in vivo three months after endothelial denudation, control segments the were suspended organ chambers at their optimal length for generating tension. Applications KCl (118 mM), acetylcholine(10(-9) to 10(-4) M), PGF2 alpha (10(-8) 3 X 10(-5) M) similar...
Abstract Successful assisted reproductive technology pregnancy depends on the viability of embryos and endometrial receptivity. However, literature has neglected effects environment during proliferative phase implantation success or failure. Human stromal cells (hESCs) were isolated from tissues sampled at oocyte retrieval women undergoing infertility treatment. Primary hESC cultures used to investigate relationship between stemness senescence induction in this population embryo Patients...
The aim was to evaluate whether natural killer (NK) cells and regulatory T (Treg) were involved in mechanisms underlying beneficial effects of a high dose intravenous immunoglobulin (IVIG) on recurrent pregnancy losses (RPL) unexplained etiology. In double-blind, randomized, placebo-controlled trial IVIG (400 mg/kg, for 5 days 4–6 weeks gestation) women with RPL, blood samples collected pre-infusion, one week after infusion (1 w), eight gestation/when miscarried (8 w). Levels NK Treg...
We tested the hypothesis that ATP-sensitive K+ channels are involved in mechanism mediating coronary autoregulation open-chest dogs. perfused left anterior descending artery with arterial blood from an extracorporeal circuit and measured steady-state flow (CBF) stepwise changes perfusion pressure (CPP) between 50 150 mm Hg during intracoronary infusion of vehicle or glibenclamide (a putative blocker channels). CBF was relatively stable over CPP 110 infusion, indicating presence at range....
Monocyte chemoattractant protein 1 (MCP-1) is a member of the C-C chemokine family and exerts strong activity in monocytes, macrophages, lymphocytes. Rat pancreatic fibrosis induced by dibutyltin dichloride (DBTC) considered to be an appropriate chronic pancreatitis model histologically enzymatically, as has demonstrated previous study.We examined effect human dominant negative inhibitor MCP-1 (mutant MCP-1) on progression DBTC rat model.We used experimental rats. Mutant or empty plasmid at...
The gap junction protein connexin45-deficient (Cx45-KO) mice die shortly after the hearts begin to beat. In addition heart defect, they also show defective vascular development which may be closely related with cardiac phenotype. Therefore, we created whose floxed-Cx45 locus could removed conditionally. We utilized α-actin-Cre transgenic investigate specific muscular function of Cx45 in vivo. resultant conditional mutants were lethal, showing conduction block similar that Cx45-KO mice....
Despite numerous reports on pregnancy outcomes after trachelectomy, there are few descriptions of fertility treatment trachelectomy. Moreover, little is known about the differences in between various radical trachelectomy procedures. The purpose this report was to clarify infertility problems that occur patients who have previously undergone an abdominal trachelectomy.We retrospectively investigated medical records 37 received treatments or were evaluated for menstrual disorders...
Pathogenesis of coronary artery spasm induced by histamine in miniature pigs was studied angiographically vivo and vitro conditions. Endothelial balloon denudation performed the animals were fed laboratory chow for 3 months, after which repeatedly provoked given intracoronarily. Regional hypercontraction documented selective arteriography, resulting myocardial ischemia confirmed ECG-ST changes. To evaluate without influence blood constituents neural control to quantitate...
This study aimed to determine whether a putative ATP-sensitive K(+)-channel blocker, glibenclamide (Glb), prevents metabolic coronary vasodilation associated with increased myocardial oxygen consumption (MVO2) caused by beta 1-adrenoceptor stimulation in anesthetized open-chest dogs. Isoproterenol (Iso) was infused selectively into the left circumflex artery before and after Glb. Coronary blood flow (CBF) an electromagnetic flowmeter, regional function sonomicrometers, ventricular arterial...
We recently demonstrated that chronic treatment with IL-1 beta induces coronary arteriosclerotic changes and vasospastic responses to autacoids in pigs vivo those are importantly mediated by PDGF. The receptors for PDGF other major growth factors known have tyrosine kinase activity. therefore investigated the effects of a selective inhibitor, ST 638, on induced our swine model. Intimal thickening serotonin histamine were at site artery where was chronically locally applied. These...