A5103066571- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Ion Transport and Channel Regulation
- Renal and related cancers
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Genetic and Kidney Cyst Diseases
- Renin-Angiotensin System Studies
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Complement system in diseases
- Platelet Disorders and Treatments
- Biomedical Research and Pathophysiology
- Wnt/β-catenin signaling in development and cancer
- Inflammatory Bowel Disease
- Reproductive System and Pregnancy
- Immunodeficiency and Autoimmune Disorders
- Pancreatic function and diabetes
- Tuberous Sclerosis Complex Research
- Systemic Lupus Erythematosus Research
- Microscopic Colitis
- TGF-β signaling in diseases
- Advanced Glycation End Products research
- Diabetes and associated disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Metabolism and Genetic Disorders
Japanese Foundation For Cancer Research
2024
Niigata University
2014-2023
Niigata University Medical and Dental Hospital
2006-2020
Ogaki Municipal Hospital
2020
Fujita Health University
2017
Niigata University of Health and Welfare
2015
Nishi Niigata Chuo National Hospital
2015
Eneos (Japan)
2014
The University of Tokyo
2007
Boston Medical Center
1995-2005
Accumulating evidence suggests that mineralocorticoid receptor blockade effectively reduces proteinuria in hypertensive patients. However, the mechanism of antiproteinuric effect remains elusive. In this study, we investigated effects aldosterone on podocyte, a key player glomerular filtration barrier. Uninephrectomized rats were continuously infused with and fed high-salt diet. Aldosterone induced progressively, associated blood pressure elevation. Notably, gene expressions...
Proteinuria is a poorly understood feature of many acquired renal diseases. Recent studies concerning congenital nephrotic syndromes and findings in genetically modified mice have demonstrated that podocyte molecules make pivotal contribution to the maintenance selective filtration barrier normal glomerulus. However, it unclear what role play proteinuria This study investigated mRNA protein expression several podocyte-associated Forty-eight patients with various diseases were studied,...
Abstract Background Chronic inflammation plays an important role in the progression of diabetic nephropathy (DN) and that infiltration macrophages glomerulus has been implicated development glomerular injury. We hypothesized plant polyphenolic compound curcumin, which is known to exert potent anti-inflammatory effect, would ameliorate macrophage streptozotocin (STZ)-induced rats. Methods Diabetes was induced with STZ (55 mg/kg) by intraperitoneal injection Three weeks after injection, rats...
We hypothesized that curcumin, by increasing the expression of nuclear factor-erythroid-2-related factor 2 (Nrf2), could reduce oxidative stress, inflammation, and renal fibrosis in remnant kidney.Sprague-Dawley rats were subjected to 5/6 nephrectomy randomly assigned untreated (Nx), curcumin-treated (75 mg/kg/day, orally), telmisartan-treated groups (10 orally; as positive control). Sham-operated also served controls. Five/sixth caused dysfunction, evidenced elevated proteinuria, blood urea...
Podocytes play an important role in maintaining normal glomerular function and structure, podocyte injury leads to proteinuria glomerulosclerosis. The family of mitogen-activated protein kinases (MAPK; extracellular signal-regulated kinase [ERK], c-Jun N-terminal kinase, p38) may be implicated the progression various glomerulopathies, but MAPK remains elusive. This study examined phosphorylation p38 clinical glomerulopathies with injury, as well rat puromycin aminonucleoside (PAN)...
mAb 5-1-6 identifies an antigen on rat podocyte slit-diaphragms and induces severe proteinuria when injected into rats. Nephrin, Ig-like transmembrane protein that is mutated in congenital nephrotic syndrome of the Finnish type, has been localized to slit-diaphragm human podocytes. Here we document nephrin. After incubation glomeruli with this mAb, antibody/antigen complex was chemically cross-linked, extracted, immunoprecipitated, prior Western analysis. By mass spectrometry 2D gel...
Visceral glomerular epithelial cells (GEC) are critical for normal permselectivity of the kidney. Nephrin is a molecule that expressed specifically in GEC structure called slit diaphragm and required morphology GEC. However, mechanisms action nephrin not understood precisely. The intracellular domain has six conserved tyrosine residues. It was hypothesized these residues phosphorylated by Src-family kinases this phosphorylation modulates function nephrin. A transient transfection system used...
Abstract. Glomerular mesangial cell proliferation and/or matrix accumulation characterizes many progressive renal diseases. Rats with mesangioproliferative glomerulonephritis were treated from day 3 to 7 after disease induction a high-affinity oligonucleotide aptamerantagonist against platelet-derived growth factor-B chain (PDGF-B). In comparison nephritic rats that received vehicle or scrambled aptamer, treatment the PDGF-B aptamer led significant reduction of changes, glomerular...
ABSTRACT. The role of the angiotensin type 2 (AT2) receptor in pathogenesis progressive renal injury has not been previously elucidated. expression AT1 and AT2 receptors subtotally nephrectomized rats (STNx) effects blockade on were explored. Reduced but was observed STNx by reverse transcription–PCR, vitro autoradiography, immunohistochemical staining. randomly assigned to antagonist valsartan, PD123319, or combination both for 4 wk. Increased proteinuria reduced PD123319 a lesser degree...
Crypt cell renewal is essential for normal intestinal homeostasis as well mucosal regeneration following injury. However, the factors regulating crypt growth in pathological conditions are not fully understood. We report here that endogenously produced chemokine CXCL10 regulates proliferation. was constitutively expressed by basal crypts mouse colon, but expression of CXCR3 enhanced epithelium proliferative zone after oral administration dextran sulfate sodium. Neutralization protected mice...
Loss of glomerular endothelial cells has been suggested to contribute the progression injury. Although therapeutic angiogenesis induced by administration bone marrow-derived progenitor observed in disease models injury, effects on renal have not clarified. Whether culture-modified marrow mononuclear would mitigate injury anti-Thy1.1 nephritis was investigated. After cultivation under conditions that promote cell growth, were labeled with CM-DiI, a fluorescence marker, and injected into left...