A5039067165- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Cervical Cancer and HPV Research
- Cancer Immunotherapy and Biomarkers
- Sperm and Testicular Function
- Cancer-related molecular mechanisms research
- Lipid metabolism and biosynthesis
- Reproductive Biology and Fertility
- CAR-T cell therapy research
- Reproductive tract infections research
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Gastric Cancer Management and Outcomes
- Bioactive Natural Diterpenoids Research
- Metallurgy and Material Forming
- Diabetic Foot Ulcer Assessment and Management
- Lower Extremity Biomechanics and Pathologies
- Endometrial and Cervical Cancer Treatments
- Biomimetic flight and propulsion mechanisms
- Immune Response and Inflammation
- Radiomics and Machine Learning in Medical Imaging
- Synthetic Organic Chemistry Methods
- Gastrointestinal Tumor Research and Treatment
Keio University
2018-2024
Nihon University
2020-2024
Morpho (United States)
2024
Nihon University Itabashi Hospital
2021
Keio University Hospital
2021
Institute for Advanced Medical Research
2020
University of Tsukuba
2016-2018
The University of Tokyo
2015-2016
Kansai University
2015-2016
Ibaraki Prefectural University of Health Sciences
2016
Background Understanding the mechanisms of non-T cell inflamed tumor microenvironment (TME) and their modulation are important to improve cancer immunotherapies such as immune checkpoint inhibitors. The involvement various immunometabolisms has recently been indicated in formation immunosuppressive TME. In this study, we investigated immunological roles stearoyl-CoA desaturase 1 (SCD1), which is essential for fatty acid metabolism, response. Methods We SCD1 by inhibition with chemical...
Temporal and distance gait factors, foot-switch contact patterns, ankle/subtalar joint motion, center of foot pressure distribution have been used to evaluate normal abnormal mechanics. A control group selected patients with well defined pathologic conditions were studied examine the effectiveness this method. Biomechanical observations reflect clinical condition. Abnormalities involving forefoot, midfoot, hindfoot are most suitable for analyzing pressure. Ankle subtalar problems by motion...
Abstract The complex ABC‐tricyclic structure of crotophorbolone, a derivative the tigliane diterpenoids, was assembled by coupling simple fragments. six‐membered C‐ring fragment, having five contiguous stereocenters, stereoselectively constructed from ( R )‐carvone. After attachment five‐membered A‐ring through π‐allyl Stille reaction, α‐alkoxy bridgehead radical reaction effected endo ‐cyclization seven‐membered B‐ring forming sterically congested bond at C9 and C10 stereospecifically...
Current xenogeneic mouse models cannot evaluate on-target off-tumor adverse effect, hindering the development of chimeric antigen receptor (CAR) T cell therapies for solid tumors, due to limited human/mouse cross-reactivity antibodies used in CAR and sever graft-versus-host disease induced by administered human cells. We have evaluated safety antitumor efficacy CAR-T cells targeting glypican-1 (GPC1) overexpressed various tumors. GPC1-specific murine generated from our original...
The biomechanical evaluation of patients with painful heels has received only limited attention although the potential morbidity and disability associated such an ailment can be severe. An objective analysis patient's foot function during gait produce useful information to assess underlying pathology. This method also help evaluate efficacy various existing treatment protocols. impulse distribution based on foot-floor vertical reaction force time under hind-, mid-, forefoot was determined in...
We previously reported that the inhibition of stearoyl-CoA desaturase 1 (SCD1) enhances antitumor function CD8
Abstract Background Although many human papillomavirus (HPV)–targeted therapeutic vaccines have been examined for efficacy in clinical trials, none translated into use. These previous agents were mostly administered by intramuscular or subcutaneous injection to induce systemic immunity. We investigated the safety and of an HPV-16 E7-expressing lacticaseibacillus-based oral vaccine. Methods In a double-blind, placebo-controlled, randomized trial, total 165 patients with HPV-16–positive...
In a clinical setting, the number of organ systems involved is crucial for differential diagnosis congenital genetic disorders. When more than one system involved, syndromic suspected. this report, we describe three patients with apparently features. Exome sequencing identified non-syndromic gene mutations as potential cause part their phenotype. The first patient (Patient 1) girl cleft lip/palate, meningoencephalocele, tetralogy Fallot, and developmental delay. second third (Patients 2 3)...
We measured the plasma 5-HT, 5-hydroxytryptophan (5-HTP), and tryptophan levels in controls, migraine patients with aura (MWA), without (MWoA) during an attack-free period.Serotonin (5-hydroxytryptamine, 5-HT) has been implicated pathophysiology of migraine. The precise relationship between 5-HT migraine, however, remains unclear.Blood samples MWA, MWoA period were collected from brachial arteries analyzed using HPLC.The 5-HTP not significantly different controls (either MWA or MWoA)....
Mammalian sperm must be activated in the tubal isthmus through capacitation to induce acrosome reaction and subsequent fertilization. Although molecular mechanisms involved have yet fully elucidated, increased concentrations of reactive oxygen species (ROS) extent tyrosine phosphorylation proteins been suggested play central roles completion capacitation. In this study, aldose reductase was for first time identified as one tyrosine-phosphorylated porcine cauda epididymal sperm. Both activity...
Previously, we have identified a calcium-binding protein that is specifically expressed in spermatids and localized to the flagella of mature sperm mouse, so-called mCABS1. However, physiological roles CABS1 male reproductive system not been fully elucidated yet. In current study, aimed localize clarify role porcine (pCABS1). We determined for first time full nucleotides sequence pCABS1 mRNA. was detected on SDS-PAGE gel as two bands at 75 kDa 70 adult testis, whereas one band epididymal...
Aims : The causal relationship of H. pylori gastric colonization with cancer development has not as yet been fully elucidated. prevalence infection increases age in the asymptomatic population Japan, and reaches a high plateau those older than 40 years. objective this study was to assess link between carcinomas patients younger Methods results Detection assessment background mucosa based on Sydney system performed histopathologically for Japanese cases years compared age‐ sex‐matched...
Abstract The complex ABC‐tricyclic structure of crotophorbolone, a derivative the tigliane diterpenoids, was assembled by coupling simple fragments. six‐membered C‐ring fragment, having five contiguous stereocenters, stereoselectively constructed from ( R )‐carvone. After attachment five‐membered A‐ring through π‐allyl Stille reaction, α‐alkoxy bridgehead radical reaction effected endo ‐cyclization seven‐membered B‐ring forming sterically congested bond at C9 and C10 stereospecifically...
Calcium-binding proteins regulate ion metabolism and the necessary signaling pathways for maturational events of sperm. Our aim is to identify novel calcium-binding in testis. The gene EFCAB2 (GenBank NM_026626.3, NP_080902.1) was not previously examined, its properties exact mechanisms action are unknown. In this study, we performed phylogenetic structure prediction analyses EFCAB2, which displays definitive structural features. Additionally, distribution, localization, calcium binding...
Abstract Stearoyl-CoA desaturase 1 (SCD1) is an attractive target for cancer therapy. However, the clinical efficacy of SCD1 inhibitor monotherapy limited. There thus a need to elucidate mechanisms resistance inhibition and develop new therapeutic strategies combination In this study, we investigated molecular by which cells acquire endoplasmic reticulum (ER) stress-dependent cell death induced inhibition. inhibitor-sensitive -resistant were treated with inhibitors in vitro, accumulated...
Ovarian cancer has a poor prognosis and is difficult to detect in early stages. Therefore, developing new diagnostic markers for early-stage ovarian critical. Here, we developed marker on the basis of fatty acid metabolism characteristics cells. The expression various metabolizing enzymes such as stearoyl-CoA desaturase 1 (SCD1) was altered tissue compared with that normal tissue. Changes enzymes, particularly SCD1, tissues were found alter concentrations multiple free acids (FFA) serum. We...
SUMMARY The gene 1700040L02Rik (GenBank accession number NM_028491, NP_082767.1) was selected by in silico screening as candidate that encodes a calcium‐binding protein sperm from database of predicted mouse cilia‐related genes. amino acid sequence revealed the presence coiled‐coil domain at C‐terminus and CLAMP motif containing leucine zipper middle protein. Assessment recombinant version this Stains‐all ruthenium red staining direct measurement terbium binding its activities. We therefore...
Early diagnosis of malignant melanoma is critical for effective treatment and reduced patient mortality. However, current clinical histological variables show limited accuracy in diagnosis. Serum or urine level 5-S-cysteinyldopa (5-S-CD) a commonly used biomarker Japan owing to its increased sensitivity compared with other markers. use as diagnostic marker has shown some limitations. Therefore, here we examined the combination 5-S-CD inhibitory activity, which showed detecting comparable...
Persistent infections with two types of human papillomaviruses (HPV), HPV16 and HPV18, are the most common cause cervical cancer (CC). Two viral early genes, E6 E7, associated tumor development, expressions E7 primarily regulated by a single promoter: P97 in P105 HPV18. We previously demonstrated that homeobox D9 (HOXD9) transcription factor is responsible for malignancy HPV16-positive CC cell lines via binding to promoter. Here, we investigated whether HOXD9 also involved regulation...