A5101912438- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- HER2/EGFR in Cancer Research
- Cardiac electrophysiology and arrhythmias
- Pancreatic and Hepatic Oncology Research
- Cardiac Arrhythmias and Treatments
- Cardiac Ischemia and Reperfusion
- Monoclonal and Polyclonal Antibodies Research
- Reproductive System and Pregnancy
- Cervical Cancer and HPV Research
- Atrial Fibrillation Management and Outcomes
- Lung Cancer Treatments and Mutations
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Epigenetics and DNA Methylation
- Neuroendocrine Tumor Research Advances
- Glycosylation and Glycoproteins Research
- Hippo pathway signaling and YAP/TAZ
- Cardiovascular Syncope and Autonomic Disorders
- Peripheral Artery Disease Management
- Endometriosis Research and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Diabetic Foot Ulcer Assessment and Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiac pacing and defibrillation studies
Kyushu University
2016-2025
Keio University
2006-2025
Kyushu University Hospital
2019-2025
Dokkyo Medical University
2008-2024
Qilu Hospital of Shandong University
2023
Tottori University
2023
Ulsan College
2023
Jichi Medical University
2023
University College London
2023
Hiroshima University
2023
Neoadjuvant therapy is recommended for treating resectable pancreatic ductal adenocarcinoma (PDAC); however, its appropriate use in patients with PDAC remains debatable. This study aimed to identify independent poor prognostic factors and evaluate the clinical significance of neoadjuvant PDAC. We retrospectively reviewed consecutive diagnosed at our institute between January 2003 December 2022. analyzed time diagnosis who underwent upfront surgery using Cox proportional hazards model overall...
Abstract Ovarian cancer is the most frequent cause of death among all gynecologic cancers. We demonstrate here that lysophosphatidic acid (LPA)-induced ectodomain shedding heparin-binding EGF-like growth factor (HB-EGF) a critical to tumor formation in ovarian cancer. found epidermal receptor (EGFR) family factors, HB-EGF gene expression cancerous tissues and protein levels patients’ ascites fluid were significantly elevated. The human cell lines SKOV3 RMG-1 form tumors nude mice. Tumor...
Chronic wounds are associated with poor epidermal and dermal remodeling. Previous work has shown the efficacy of keratinocyte growth factor (KGF) in reepithelialization elastin wound healing. Here we demonstrate fabrication a fusion protein comprising elastin-like peptides KGF. This retains performance characteristics KGF as evidenced by its enhancement fibroblast proliferation. It also preserved characteristic inverse phase transitioning allowing recombinant to be expressed bacterial hosts...
Recent studies revealed that a class III semaphorin, semaphorin 3E (Sema3E), acts through single-pass transmembrane receptor, plexin D1, to provide repulsive cue for D1-expressing endothelial cells, thus providing highly conserved and developmentally regulated signaling system guiding the growth of blood vessels. We show here Sema3E as potent inhibitor adult tumor-induced angiogenesis. Activation D1 by causes rapid disassembly integrin-mediated adhesive structures, thereby inhibiting cell...
The abundant flavonoid aglycone, naringenin, which is responsible for the bitter taste in grapefruits, has been shown to possess hypolipidemic and anti-inflammatory effects both vitro vivo. Recently, our group demonstrated that naringenin inhibits hepatitis C virus (HCV) production, while others its potential treatment of hyperlipidemia diabetes. However, suffers from low oral bioavailability critically limiting clinical potential. In this study, we demonstrate solubility enhanced by...
Interfering with a specific G protein–coupled receptor pathway may provide therapeutic approach to blocking metastasis of some forms breast cancer.
Abstract Purpose: Lysophosphatidic acid, which is enriched in the peritoneal fluid of ovarian cancer patients, plays a key role progression cancer. acid can generate epidermal growth factor receptor (EGFR) signal transactivation involving processing EGFR ligands by ADAM (a disintegrin and metalloprotease) family metalloproteases. We aimed to investigate clinical significance lysophosphatidic acid–induced pathogenesis Experimental Design: examined expression members 108 patients with normal...
Abstract Heparin-binding epidermal growth factor–like factor (HB-EGF) is involved in several biological processes including cell adhesion, invasion, and angiogenesis. HB-EGF also plays a pivotal role the progression of ovarian cancer. To investigate significance peritoneal dissemination, we examined roles angiogenesis Through suppression focal adhesion kinase EGF receptor activation, adhesive properties mediated by integrin β1 were diminished inhibition expression. The reduction expression...
Nicorandil has cardioprotective effects in the ischemic myocardium, mimicking preconditioning, and is thus expected to improve prognosis of heart disease (IHD). As part Japanese Coronary Artery Disease (JCAD) Study, a multicenter collaborative prospective observational study large cohort coronary artery patients, effect nicorandil on outcome was examined.In total, 2,558 patients with treatment controls subjected propensity score matching were eligible among 13,812 registered JCAD study. The...
<title>Abstract</title> Background Chemotherapeutic advances have increased opportunities for conversion surgery (CS) of unresectable locally advanced (UR-LA) pancreatic cancer (PC). However, the optimal indications CS remain unclear. We aimed to identify predictive factors prognosis in UR-LA PC, and evaluate indication using these including sarcopenia. Methods In this retrospective study, we reviewed consecutive patients with PC who had received chemo(radio)therapy as an initial treatment...
This study examined factors that affected sentinel lymph node (SLN) identification of patients with endometrial cancer having a preoperative estimation low recurrent risk.
Clear cell carcinoma of the uterine cervix is a rare subtype. We report case 14-year-old girl who presented with abnormal genital bleeding, 7 cm mass arising from cervix, and swollen right inguinal lymph nodes. Histological immunohistochemical examinations showed clear carcinoma. performed modified-radical hysterectomy, bilateral salpingo-oophorectomy, node biopsy, pelvic para-aortic diagnosed cervical cancer stage IVB (clear carcinoma, pT2bN2M1). administered...
Background: A molecular classification of endometrial cancer was developed based on an analysis The Cancer Genome Atlas. In this classification, the group characterized by abnormal p53 immunohistochemical expression showed poorest prognosis. However, there may be no need to apply a in low-grade cancer. study, we investigated clinical significance Methods: We obtained nine frozen samples [low-grade with wild-type (EClop53wt group): n = 3, (EClop53ab and high-grade (EChi 3]. RNA sequencing...
Background Aortic pulse wave velocity has been used for evaluating atherosclerosis. Recently, the development of volume plethysmographic method made it possible to easily measure index velocity. The brachial ankle and cardio vascular are estimating extent diagnostic usefulness these indexes in predicting coronary artery disease was examined. Methods velocity, index, high-sensitivity C-reactive protein were measured 696 patients who had chest pain underwent angiography. Measurement values...
Heparin-binding EGF-like growth factor (HB-EGF) plays a pivotal role in tumor and clinical outcomes patients with ovarian cancer, leading to the validation of HB-EGF as target for cancer therapy. In this study, we investigated anti-tumor effects paclitaxel, an anti-cancer agent, CRM197, specific inhibitor off HB-EGF, cancer. Paclitaxel induced transient ERK activation sustained JNK p38 MAPK through ectodomain shedding SKOV3 cells. addition, overexpression paclitaxel-treated cells resulted...
BHLHE40 and BHLHE41 (BHLHE40/41) are basic helix-loop-helix type transcription factors that play key roles in multiple cell behaviors. BHLHE40/41 were recently shown to be involved an epithelial-to-mesenchymal transition (EMT). However, the precise mechanism of EMT control by remains unclear. In present study, we demonstrated expression was controlled a pathological stage-dependent manner human endometrial cancer (HEC). Our vitro assays showed suppressed tumor invasion. also effectors SNAI1,...
FBXW 7 is a ubiquitin ligase that mediates ubiquitylation of oncoproteins, such as c‐Myc, cyclin E, Notch and c‐Jun. known tumor‐suppressor gene, mutations in have been reported various human malignancies. In this study, we examined the sequences p53 genes 57 ovarian cancer clinical samples. Interestingly, found no associated with amino acid changes. We also investigated expression levels 126 epithelial tumors. was negatively correlated malignant potential That to say, samples were...