A5043800120- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Urinary Bladder and Prostate Research
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Hormonal and reproductive studies
- Pelvic floor disorders treatments
- Nitric Oxide and Endothelin Effects
- Hormonal Regulation and Hypertension
- PARP inhibition in cancer therapy
- Venous Thromboembolism Diagnosis and Management
- Sexual function and dysfunction studies
- Stress Responses and Cortisol
- Prostate Cancer Diagnosis and Treatment
- Gynecological conditions and treatments
- Lymphoma Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Birth, Development, and Health
- Urinary Tract Infections Management
- Anesthesia and Neurotoxicity Research
- Cancer Treatment and Pharmacology
- Urologic and reproductive health conditions
- Bladder and Urothelial Cancer Treatments
- Pregnancy and preeclampsia studies
Jikei University School of Medicine
2015-2024
Noguchi Hospital
2024
Kōchi University
2014-2023
National Cancer Research Institute
2022
Jikei University Kashiwa hospital
2022
National Cancer Center Hospital East
2022
Mita Hospital
2021
Katsushika Medical Center
2020
Shikoku (Japan)
2019
University of Ioannina
2016
We aimed to develop an ovarian cancer-specific predictive framework for clinical stage, histotype, residual tumor burden, and prognosis using machine learning methods based on multiple biomarkers.Overall, 334 patients with epithelial cancer (EOC) 101 benign tumors were randomly assigned "training" "test" cohorts. Seven supervised classifiers, including Gradient Boosting Machine (GBM), Support Vector Machine, Random Forest (RF), Conditional RF (CRF), Naïve Bayes, Neural Network, Elastic Net,...
Gastric-type mucinous carcinoma (GAS) is a novel variant of the uterine cervix. As shown in original Japanese group description, recent studies, GAS represents more aggressive disease than usual-type endocervical adenocarcinoma (UEA). Detailed clinicopathological features this remain to be elucidated larger series patients.Patients were enrolled by Gynecologic Cancer Study Group Japan Clinical Oncology after receiving approval each Institutional Review Board. The study population comprised...
The efficacy of taxane plus platinum regimens has been demonstrated for advanced or recurrent endometrial cancer; however, it not assessed in postoperative adjuvant chemotherapy cancer.To evaluate the clinical benefit compared with standard doxorubicin cisplatin as cancer.In this multicenter, open-label, phase 3 randomized trial, patients cancer at high-risk stage I II III IV that did extend beyond abdominal cavity and had 2 cm greater residual tumor were included from 118 institutions Japan...
BACKGROUND: Intraperitoneal chemotherapy has been shown to be effective at reducing mortality for patients with advanced epithelial ovarian cancer but is not widely used in practice. METHODS: We performed the Therapy Ovarian Cancer Carboplatin (iPocc) trial as an open-label, international, multi-institutional, randomized phase 2/3 clinical women newly diagnosed who underwent laparotomy or laparoscopy. All received intravenous paclitaxel (80 mg/m2 on days 1, 8, and 15 of a 21-day cycle). In...
Abstract Aim The aim of this study was to compare the efficacy and safety enoxaparin intermittent pneumatic compression (IPC) for venous thromboembolism (VTE) prevention in Japanese surgical patients with gynecologic malignancy. Material Methods Patients ≥40 years old undergoing major surgery malignancy without preoperative VTE were included. Written informed consent obtained. Enrolled received IPC immediately before surgery. After surgery, they randomly assigned either an group or IPC‐alone...
Epithelial ovarian cancer (EOC) is the most common cause of gynecological malignancy-related mortality. Ovarian clear cell carcinoma (CCC) has unique clinical characteristics and behaviors that differ from other histological types EOC, including a frequent association with endometriosis highly chemoresistant nature, resulting in poor prognosis. However, factors underlying its malignant behavior are still poorly understood. Aberrant expression microRNAs been shown to be involved oncogenesis,...
This study compared the effectiveness, safety, and tolerability of dose-dense paclitaxel carboplatin plus bevacizumab (ddTC+Bev) with ddTC for advanced ovarian cancer.
// Asuka Morikawa 1, 2 , Tomoatsu Hayashi 1 Naomi Shimizu Mana Kobayashi Kenzui Taniue Akiko Takahashi Kota Tachibana Misato Saito Ayako Kawabata Yasushi Iida Kazu Ueda Motoaki Nozomu Yanaihara Hiroshi Tanabe 3 Kyosuke Yamada Hirokuni Takano Osamu Nureki 4 Aikou Okamoto and Tetsu Akiyama Laboratory of Molecular Genetic Information, Institute Cellular Biosciences, The University Tokyo, Japan Department Obstetrics Gynecology, Jikei School Medicine, University, Kashiwa Hospital, Chiba,...
Aim The aim of this study was to evaluate the impact surgical staging in stage I clear cell adenocarcinoma ovary (CCC). Methods We performed a retrospective review 165 patients with CCC treated optimal or nonoptimal surgery. Results median follow-up period 67 months. No significant difference detected recurrence-free survival (RFS) overall (OS) between optimally and nonoptimally staged (RFS: P = 0.434; OS: 0.759). estimated 5-year RFS OS rates were 92.1% 95.3% stages IA/IC1 81.0% 83.7%...
Brain concussions are a serious public concern and associated with neuropsychiatric disorders, such as depression. Patients concussion who suffer from depression often experience distress. Nevertheless, few pre-clinical studies have examined concussion-induced depression, there is little information regarding its pharmacological management. Edaravone, free radical scavenger, can exert neuroprotective effects in several animal models of neurological disorders. However, the effectiveness...
Dedifferentiated endometrial carcinoma, which is defined microscopically as the co-existence of undifferentiated carcinoma and grade 1 or 2 endometrioid adenocarcinoma, an aggressive type cancer regardless percentage components. It reported that comprises 9% carcinoma. The dedifferentiated has been hypothesized to be 40% A precise pathological diagnosis essential for defining appropriate therapeutic approach prognosis. Furthermore, since there association between Lynch syndrome, it important...
We studied the properties of endothelin receptors in prostate 8-week streptozotocin-diabetic and control rats. The density receptors, as determined by saturation experiments with [125I]endothelin-1, were 95.8 ± 5.4 171.3 16.7 fmol/mg protein diabetic rat prostates, respectively. pharmacological profile was similar both groups consistent predominance ETA receptor subtype prostate. Thus, induction diabetes upregulates expression prostate, but does not alter these tissues.
Objective: The treatment effects of vibegron have not previously been evaluated in a prospective, non-interventional observational study elderly Japanese patients, particularly those ≥ 80 years old. In addition, no reports referred to residual urine volume switching cases. We therefore grouped patients by condition and investigated the on Overactive Bladder Symptom Score (OABSS), Questionnaire Short Form (OAB-q SF), each group. Methods: This multicenter, non-interventional, consecutively...
5503 Background: The superiority of chemotherapy regimens employing a taxane plus platinum agent over standard therapy with doxorubicin cisplatin (AP) was recently demonstrated for advanced or recurrent endometrial cancer. This multicenter phase III trial evaluated the clinical benefit as adjuvant compared AP cancer patients at high risk recurrence after surgery. Methods: Endometrial having and postoperative residual disease < 2 cm were randomly assigned (1:1:1) stratification by FIGO...
You have accessJournal of UrologyInfections/Inflammation the Genitourinary Tract: Kidney & Bladder1 Apr 2012907 EFFECT OF INTRAVESICAL BOTULINUM TOXIN A DELIVERY (USING DMSO) IN RAT OVERACTIVE BLADDER MODEL Shogo Shimizu, Marcia Wheeler, Motoaki Saito, Robert Weiss, and Adam Hittelman ShimizuShogo Shimizu New Haven, CT , WheelerMarcia Wheeler SaitoMotoaki Saito Yonago, Japan WeissRobert Weiss HittelmanAdam View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1003AboutPDF...
The object of this study is to evaluate the clinical safety and efficacy total parietal peritonectomy (TPP) in primary debulking surgery (PDS) for advanced ovarian cancer. This retrospective single-center analyzed 16 patients with FIGO stages IIIC-IVB epithelial cancer who underwent TPP PDS achieved macroscopically complete resection between April 2015 June 2016. median age was 52.5 years old. 12 were stage IIIC 4 IV. Regarding intraoperative complications, unintended diaphragm perforation...
We investigated the predictive value of scoring systems peritoneal disseminations for complete surgery (CS) at primary debulking (PDS) in advanced ovarian cancer.We retrospectively enrolled eligible patients with clinical stages III or IVA selected PDS from January 2015 to December 2019. Concern variables were index (PIV) and cancer (PCI) operative pathological reports. Primary endpoints cutoffs predict completeness using receiver operating characteristic curve.Among 111 patients, PIV ≥8 PCI...