A5056157068- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Sexual Differentiation and Disorders
- Urologic and reproductive health conditions
- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Tissue Engineering and Regenerative Medicine
- Estrogen and related hormone effects
- Genital Health and Disease
- Testicular diseases and treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Bladder and Urothelial Cancer Treatments
- Urinary Tract Infections Management
- Prostate Cancer Treatment and Research
- Diversity and Career in Medicine
- Healthcare Policy and Management
- Renal and related cancers
- Global Health Workforce Issues
- Kidney Stones and Urolithiasis Treatments
- Sexual function and dysfunction studies
- Renal cell carcinoma treatment
- Effects and risks of endocrine disrupting chemicals
- Hormonal Regulation and Hypertension
- Prostate Cancer Diagnosis and Treatment
- Educational Robotics and Engineering
Yale University
2014-2024
Yale New Haven Hospital
2017-2024
Children's Healthcare of Atlanta
2020
Emory University
2020
University of New Haven
2010-2018
University of California, San Francisco
2004-2010
Johns Hopkins University
2010
UCSF Helen Diller Family Comprehensive Cancer Center
2007
New York University
1999-2002
Neurological Surgery
1995
The glucocorticoid receptor (GR) is phosphorylated at multiple sites within its N terminus (S203, S211, S226), yet the role of phosphorylation in function not understood. Using a range agonists and GR site-specific antibodies, we demonstrated that transcriptional activation greatest when relative S211 exceeds S226. Consistent with this finding, replacement S226 an alanine enhances response. battery compounds perturb different signaling pathways, found BAPTA-AM, chelator intracellular...
We determined the relationship between clinical variables and testicular histopathological changes associated with decreased fertility potential in children cryptorchidism.Testis biopsies of 274 who underwent orchiopexy concurrent biopsy 1991 2001 were analyzed for germ Leydig cell loss, fibrosis. Multivariable logistic regression was used to determine if age at (analyzed as continuous ordinal variables), preoperative testis palpability, unilateral vs bilateral disease and/or side...
BACKGROUNDAnimal models of endocrine dysfunction have associated male genital defects with reduced anogenital distance (AGD). Human studies correlated shorter AGD exposure to putative disruptors in the environment but not examined hypospadiac boys. We measured boys hypospadias and those normal genitals.
Abstract Penetration of the bladder permeability barrier (BPB) is a major challenge when treating diseases via intravesical delivery. To increase transurothelial migration and tissue tumor cell uptake, poly(lactic-co-glycolic acid; PLGA) nanoparticles (NP) were modified by addition low molecular weight (2.5 or 20 kDa) positively charged mucoadhesive polysaccharide, chitosan, to NP surface. In designing these NPs, we balanced adhesive properties chitosan with release bioactivity siRNA....
Glucocorticoids act through the glucocorticoid receptor (GR), which can function as a transcriptional activator or repressor, to elicit cytostatic and cytotoxic effects in variety of cells. The molecular mechanisms regulating these events target genes affected by activated remain largely undefined. Using cultured human osteosarcoma cells model for GR antiproliferative effect, we demonstrate that U20S cells, activation leads irreversible growth inhibition, apoptosis, repression Bcl2. This...
The androgen receptor (AR) is a ligand-regulated transcription factor that stimulates cell growth and differentiation in androgen-responsive tissues. AR N terminus contains two activation functions (AF-1a AF-1b) are necessary for maximal transcriptional enhancement by the receptor; however, mechanisms components regulating not fully understood. We sought to identify novel factors interact with from an androgen-stimulated human prostate cancer library using yeast two-hybrid approach designed...
To quantitatively assess the effect of radical prostatectomy (RP) on specific domains that comprise overall sexual function (SF), focusing relationships among these and SF, to identify predictors for recovery SF over time, as a decline in bother (SB) are known potential complications treatment prostate cancer.Within Cancer Prostate Strategic Urologic Research Endeavor database, we identified men diagnosed between 1995 2001 with localized cancer treated RP. SB outcomes, measured using...
Abstract Background A positive urine culture often drives initiation of antimicrobials even in the absence symptoms. Our objectives were to evaluate knowledge and practice patterns related ordering cultures patients with indwelling urinary catheters. Methods We performed chart reviews catheter-associated tract infections (CAUTIs) at our academic health care system between October 1, 2015, September 30, 2017, assess assessment potential CAUTIs. Following this, we surveyed physicians nurses...
Rare earth metal magnets (Buckyballs and similar products) remain an important public health risk for children. We report the presentation, course, treatment of a boy who inserted string 30 through his urethra into bladder review diagnostic as well therapeutic options foreign bodies pediatric urogenital tract.
Renal cell carcinoma (RCC) represents a small proportion of renal malignancies early in life. Distinguishing RCC from other is important as treatment strategies may differ. We analyze the Surveillance Epidemiology, and End Results (SEER) database to identify predictive factors pediatric population with tumors.We queried SEER patients ages 0 19 diagnosed malignancy between 1973 2013. Cases were sorted using histology site codes. Age-adjusted standardized incidence rates (SIR) calculated....
Ornithine decarboxylase (ODC) is a rate-determining enzyme of the polyamine-biosynthetic pathway. We sought to produce cells with impaired ODC function in order study biological functions polyamines. Saccharomyces cerevisiae strains were obtained by one-step gene replacement 900 bp fragment yeast (SPE1) URA3 gene. Spores derived from SPE1/spe1 germinated at reduced efficiency relative SPE1/SPE1. Sustained growth spe1 haploid mutants polyamine-free medium led intracellular polyamine...
Objective: To assess whether communication training for house staff via role-playing exercises (1) is well received and (2) improves patient experience scores in clinics. Methods: We conducted a pre–post study which the 3 adult hospital departments participated led by trained faculty small groups. Sessions centered on published 5-step strategy opening patient-centered interviews using department-specific exercises. House completed posttraining questionnaires. For 1 month prior to following...
What’s known on the subject? and What does study add? Mitomycin C is widely used for treatment of bladder cancer, however disease progression after mitomycin common. We found that intravesical increases urinary vascular endothelial growth factor (VEGF) VEGF receptor‐2 protein mRNA in rats. also levels cancer cells. Therefore, we speculate may increase angiogenic potential both normal OBJECTIVES To examine, using vitro vivo models, largely unexamined effect (MMC), an effective superficial...
There is a large amount of intra and inter observer variability in defining curve shapes. This study aims to evaluate rater reliability (RR) on evaluating uroflow curves broad spectrum international practitioners.Eight hundred sixty-four questionnaires were sent by email health professionals that care for children with voiding dysfunction. It included demographic questions 11 different two duplicates.Four forty-one emails opened 29.5% those responded. Seventy percent responders physicians,...
Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal and information, but is committed maintaining privacy will not share personal information without express consent. For more please refer our Privacy Policy. eTOC Secondary Logo Journal All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Login & Issues Current IssuePrevious IssuesPublished Ahead-of-Print Authors...
Objective Acquired clitoromegaly is rare and may result from hormonal nonhormonal causes, evaluation of the pregnant patient with invokes a specific set differential diagnoses. Methods Case report. Results We describe case young woman pregnancy-associated clitoral enlargement whose proved negative. Further investigation concluded that an epidermoid cyst was culprit her pseudoclitoromegaly. The underwent successful surgical resection has had no recurrence at subsequent pregnancy. Conclusion...
Background: Abnormalities of mesonephric ducts are rare congenital conditions, which can present with vague symptoms in otherwise healthy men. Zinner's syndrome is the association an enlarged seminal vesicle cyst ipsilateral renal agenesis, be symptomatic and require operative interventions. Case: We case 24-year-old man who presented a 15 cm cyst, was completely excised using robot-assisted approach. Conclusion: Use robotic surgery for excision large cysts safe effective procedure.